A randomized trial of patient navigation with symptom-monitoring in advanced lung cancer.

Aim: Patient navigators can help overcome barriers to cancer care. We evaluated the impact of patient navigation with symptom-monitoring in patients with advanced lung cancer.

Methods: In this randomized study, adult patients (>18 years) with advanced lung cancer planned for palliative systemic therapy were assigned 1:1 to an intervention or standard care arm.

Assessing biosimilarity of insulin aspart injection and NovoRapid® through pharmacokinetic and pharmacodynamic comparisons in healthy volunteers: A double-blind, randomized, crossover study.

Aim: This study compares the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of Insulin Aspart Injection IP/BP (Recombinant DNA origin) 100 IU/mL (Wockhardt Limited) and NovoRapid® Penfill® Insulin Aspart 100 IU/mL (Novo Nordisk A/S, Denmark) using a double-blind, randomized, single-center, two-period, crossover design in healthy subjects using euglycemic clamp technique.

Methods: A Total of 56 healthy subjects were enrolled in the study, received a single subcutaneous dose of 0.3 IU/kg of either the test or reference formulation on two separate occasions.

Conserved biochemical activity and function of phosphatidylinositol 5-phosphate 4-kinase regulates growth and development.

Co-ordination of function between multiple cells, mediated by hormones or growth factors, is a crucial requirement for multicellularity. Phosphoinositides, generated by lipid kinase activity, are second messengers that mediate such signalling. Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) is a lipid kinase that phosphorylates phosphatidylinositol 5-phosphate (PI5P) to generate phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

Stereotactic ablative radiation therapy for extracranial metastases from malignant melanoma: An international multi-institutional analysis.

Objective: To report on local control (LC), toxicity, and overall survival (OS) following stereotactic ablative radiation therapy (SABR) for extracranial metastases from malignant melanoma.

Methods: The RSSearch Patient Registry was searched for patients with extracranial melanoma metastases treated with SABR. LC was defined as the time from completion of SABR to the date of last radiographic follow-up with either stability or decrease in size of the treated metastasis or the date at which lesion growth was radiographically confirmed per RECIST criteria.

Global trends and perspectives in nanochitin research: A comprehensive review of types, properties, applications, and scientometric analysis.

This review presents a detailed exploration of global trends and prospects in nanochitin research, focusing on its types, properties, applications, and scientometric analysis. Nanochitin, a nanoscale derivative of chitin, has gained significant interest due to its unique properties, such as mechanical strength, biocompatibility, and biodegradability. This paper explores various forms of nanochitin, including chitin nanocrystals (ChNCs)/chitin nanowhiskers (ChNWs) and chitin nanofibers (ChNFs), and their broad applicability across sectors such as food, electronics, agriculture, biomedicine, environment, and cosmetics.

Chronic statin-use before PCI in acute coronary syndromes and in-hospital outcomes: ACC-NCDR registry in India.

Objective: To compare in-hospital major cardiovascular adverse outcomes among chronic statin-user and statin-naïve acute coronary syndrome(ACS) patients following percutaneous coronary intervention(PCI).

Methods: Successive patients with ACS who underwent PCI from Sep'17 to Dec'23 were enrolled in a prospective registry. Details of risk factors, presentation, angiography, interventions, and in-hospital outcomes were recorded.

Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment.

Terminal cell differentiation, a process vital for tissue development and regeneration where progenitor cells acquire specialized functions and permanently exit the cell cycle, is still poorly understood at the molecular level. Using live-cell imaging and adipogenesis as a model, we demonstrate that the initial stage involves a variable number of cell divisions driven by redundant CDK4/6 or CDK2 activation..

Integration of Conjugated Linoleic Acid-Producing Probiotic Strains Having Anti-adipogenic Properties with Honey and Oyster Mushrooms for the Formulation of Non-dairy Probiotic Beverage.

Conjugated linoleic acid (CLA) has been linked to various health benefits, including anti-cancer, anti-diabetic, and anti-obesity effects. Obesity, marked by abnormal fat deposition, increases the risk of metabolic disorders such as cardiovascular diseases and type-2 diabetes. Natural anti-adipogenic modulators with insulin sensitivity are one of the approaches to address the issue.

Flood exposure and childhood malnutrition in India using composite index of anthropometric failure (CIAF).

The flood exposure in India exacerbates childhood malnutrition, particularly in the vulnerable regions of India. Presently, India is facing a dual burden of natural disasters and malnutrition, especially in the vulnerable regions that are exposed to floods. Many studies have been focused on micro-level or regional-level analyses.

Comparative chemical profiling, antimicrobial activity of (Pers.) Sprague ex Britton and P. Wilson essential oil and evaluation of their integrative network pharmacology.

is an annual herb of the Apiaceae family. This study aims to investigate the chemical compositions of aerial, fruits, leaves, and stem parts and evaluate their potential anti-microbial activity. For the identification and quantification of essential oil (EO) constituents gas chromatography-mass spectrometry and gas chromatography-flame ionisation detector techniques was used.

Multifaceted Role of Probiotics in Enhancing Health and Growth of Aquatic Animals: Mechanisms, Benefits, and Applications in Sustainable Aquaculture-A Review and Bibliometric Analysis.

Probiotics play a pivotal role in enhancing the health and growth of aquatic animals in aquaculture. These beneficial microorganisms contribute to improved digestion and nutrient absorption by producing digestive enzymes such as amylases, proteases, and lipases, besides providing essential nutrients. By creating a favorable microbial balance in the gastrointestinal tract (GIT), probiotics reduce harmful microorganisms and promote the proliferation of beneficial bacteria like spp.

Historical data provide new insights into inheritance of traits important for diploid potato breeding.

Using a diploid potato diversity panel of 246 breeding lines, a genotyping-by-sequencing and a GWAS approach, we mapped QTL for ten traits important to potato breeders, including two previously unmapped traits: boiled tuber taste and pollen fertility. Potato breeding at the diploid level has a long history and has gained new impetus recently, when F1 hybrid breeding was made possible with the discovery of a dominant gene for self-compatibility. Our study deploys a unique diploid diversity panel with a broadened cultivated potato gene pool obtained as a result of introgressing valuable traits from wild potato relatives into the Solanum tuberosum background.

Influence of Bemisia tabaci-Induced Plant Volatiles on the Host-Choice Behavior of Tuta absoluta.

Plants respond to attacks by insects by releasing herbivore-induced plant volatiles (HIPVs), which are known to influence the behavior of natural enemies, conspecific and heterospecific insects. However, little is known about how HIPVs induced by one insect species influence the behavior of an allospecific insect species, particularly if these insects belong to different feeding guilds. Here, using the interaction of two co-occurring insects with different feeding guilds - Bemisia tabaci (a sap sucking insect) and Tuta absoluta (a leaf mining insect) - on potato plants, we report that T.