Publications by authors named "Samira Ezi"
Psychotropic stimulants like methamphetamine (METH) have an impact on the physiology, behavior, and psychology of human beings and can damage the reproductive and neuroendocrine systems in them. These deleterious impacts include a temporary drop in the relative weight of the testis along with adverse effects on spermatogenesis. Sambucus nigra, also known as elderberry (EB) or sweet elder, is a source of bioactive compounds that has drawn growing attention for its potential beneficial impact in preventing and treating several diseases.
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- Tramadol is a widely used opioid pain reliever that affects pain and can also be used for treating depression and anxiety, but it has potential for causing serious damage to areas of the central nervous system (CNS), particularly the hippocampus.
- The study reviewed articles from 2000 to 2022 to assess how tramadol impacts the CNS, revealing processes like cell death and dysfunction that affect neural cell function.
- The findings suggest that tramadol can lead to a significant decrease in neural cell count and volume, potentially causing neuropsychological issues such as memory problems and cognitive deficits, indicating the need for more research on its effects.
Article Synopsis
- Tramadol, a synthetic opioid similar to codeine, causes neurodegeneration and behavioral impairments, particularly affecting learning and memory in the hippocampus, yet there’s limited research on its gene expression effects.
- The study investigated tramadol's impact on both PC12 cell lines (in vitro) and hippocampal tissue (in vivo), utilizing RNA sequencing and stereological analysis after chronic exposure to assess changes at the molecular, structural, and functional levels.
- Results showed that tramadol increased reactive oxygen species and neurodegenerative gene expressions, leading to hippocampal atrophy and impaired spatial learning and memory, indicating its neurotoxic effects.
Article Synopsis
- Parkinson disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to motor function issues in patients.
- The study evaluated the potential of human olfactory ecto-mesenchymal stem cells (OE-MSCs) as a cell replacement therapy in rat models of PD, demonstrating their ability to improve motor skills and increase key dopamine-related markers.
- Results showed that transplanting OE-MSCs into the brains of PD-affected rats not only enhanced motor coordination and performance but also indicated their effectiveness as a potential treatment avenue for neurodegeneration in PD.
Article Synopsis
- Tramadol, a synthetic opioid and SNRI resembling codeine and morphine, was studied for its effects on the cerebellum due to its neurotoxicity.
- In an experiment with 24 male albino rats, those receiving tramadol daily for 3 weeks showed significant cerebellum atrophy, neuroinflammation, and impaired motor coordination.
- The study found that tramadol led to decreased levels of VEGF and disrupted key signaling pathways related to neurodegeneration and energy metabolism in the cerebellar cortex.
Article Synopsis
- Tramadol, a synthetic pain relief medication, was examined for its effects on gene expression related to cell death and self-digestion in nerve cells (PC-12 cells) and its impact on rat brains over chronic exposure.
- The study involved exposing PC-12 cells to tramadol in the lab and administering it to rats daily for three weeks to observe changes in their motor skills and brain structure.
- Results showed that tramadol increased harmful gene expression in nerve cells, led to brain cell death and inflammation in rats, and negatively affected their motor coordination, indicating potential neurotoxicity.
Article Synopsis
- ADHD is a prevalent developmental disorder, often treated with Methylphenidate (MPH), but concerns about its side effects on brain development are rising.
- This study aimed to investigate the negative effects of MPH on the hippocampus of rats using various behavioral and biochemical tests.
- Results showed that MPH reduced rats' willingness to explore new environments and did not improve memory or learning, while also increasing astrogliosis in the hippocampus, highlighting the need for further research on MPH's impact on brain health.
The effect of 3-nitropropionic acid on behavioral dysfunction, neuron loss and gliosis in the brain of adult male rats: The case of prefrontal cortex, hippocampus and the cerebellum.
Abolfazl Torabi
,
Mohammadjavad Joneidi
,
Ibrahim Mohammadzadeh
,
Mohammad-Amin Abdollahifar
,
Aysan Khatmi
,
Samira Ezi
Toxicon
August 2020
3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin on different regions of the brain. In the present study, there are two groups of rats of which one is treated with 3-NP.
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- Tramadol, a synthetic drug similar to codeine, is prescribed for mild to moderate pain but can cause side effects like emotional instability and anxiety.
- A study found that chronic tramadol exposure led to structural and functional changes in the prefrontal cortex, including increased levels of reactive oxygen species and significant cell death markers.
- The drug's neurotoxic effects were linked to neuroinflammation, resulting in atrophy, apoptosis, and behavioral and cognitive impairments in the subjects studied.
Article Synopsis
- No definitive cure exists for degenerative cerebellar disease, prompting a trial to investigate the neuroprotective effects of Sertoli cells (SCs) in alleviating cerebellar ataxia symptoms.
- The study involved isolating SCs from immature male rats, confirming the presence of key neurotrophic factors, and testing the cells' effects on both cultured nerve cells and rat models of ataxia.
- Results showed that SCs improved motor and neuromuscular functions by reducing cell death, but further research is needed to verify their effectiveness for treating humans with cerebellar ataxia.