Publications by authors named "Runfa Chen"

Unsupervised non-rigid point cloud shape correspondence underpins a multitude of 3D vision tasks, yet itself is non-trivial given the exponential complexity stemming from inter-point degree-of-freedom, i.e., pose transformations.

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  • Histone H3 Lys36 (H3K36) methylation, particularly H3K36 dimethylation (H3K36me2) and trimethylation (H3K36me3), plays significant roles in DNA double-strand break (DSB) repair through two pathways: non-homologous end joining (NHEJ) and homologous recombination (HR).
  • Yeast cells lacking either H3K36me2 or H3K36me3 show reduced efficiency in DSB repair, with proteins yKu70 and Rfa1 interacting with these methylation forms to facilitate the repair process.
  • These findings indicate that different forms of H3K36 methylation are essential for
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Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of H3K36me3 during aging remains poorly understood. Here, we report that the degradation of the methyltransferase Set2 is the cause of decreased H3K36me3 levels during chronological aging in budding yeast.

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Microbially induced calcite precipitation (MICP) has been shown to mitigate sand erosion; however, few studies have applied MICP on loess soils. In this study, polyacrylamide (PAM) was added to the cementation solution, and combined MICP-PAM treatment was applied to improve the surface erosion resistance of loess-slopes. The freeze-thaw (FT) durability of MICP-PAM treated loess slopes was also studied.

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Purpose: Breast cancer (BC), with varying histopathology, biology and response to systemic treatment, is the second leading cause of cancer-related mortality. Previous studies have inferred that the expression of mitochondrial ribosomal proteins (MRPs) is possibly related to the occurrence/progression of BC. MRPL13 might be one of the potential MRP candidates that are involved in BC tumorigenesis, but its role in BC has rarely been reported.

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  • The study investigates how Rph1 regulates the transcription of ribosomal RNA (rRNA) and ribosomal protein genes (RPGs) in yeast, which is crucial for cellular growth control.
  • Rph1 is shown to interact with both RNA polymerase I (RNAPI) and RNA polymerase II (RNAPII) genes, and its deletion improves growth in nutrient-stressed conditions by enhancing rRNA and RPG transcription.
  • The research suggests that Rim15 kinase phosphorylates Rph1 during nutrient stress, and this modification promotes cell growth and survival by causing Rph1 to dissociate from chromatin, thus coordinating transcription processes.
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A low production rate for calcium carbonate with microbial solidification technology at low temperatures often restricts its application. For this reason, adding urea to the medium and the domestication of Bacillus megaterium at low temperature were proposed to produce more calcium carbonate based on an analysis of growth characteristics, urease activity, and the production rates for calcium carbonate under different conditions. Sand solidification tests were conducted to demonstrate improvements caused by the methods.

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N-lysine acetylation represents a highly dynamic and reversibly regulated post-translational modification widespread in almost all organisms, and plays important roles for regulation of protein function in diverse metabolic pathways. However, little is known about the role of lysine acetylation in photosynthetic eukaryotic microalgae. We integrated proteomic approaches to comprehensively characterize the lysine acetylome in the model diatom In total, 2324 acetylation sites from 1220 acetylated proteins were identified, representing the largest data set of the lysine acetylome in plants to date.

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  • * This study details the biosynthetic steps of MonAzPs in a specific fungus (M7) using gene knockouts and other techniques.
  • * It represents the first successful engineering of MonAzPs biosynthesis, offering a framework for future efforts to enhance the production of valuable pigments and for studying fungal azaphilone production.
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