Association of mixed polycyclic aromatic hydrocarbons exposure with hearing loss and the mediating role of blood cell markers of inflammation in U.S. adults.

Introduction: Studies on the effects of polycyclic aromatic hydrocarbons (PAHs) on hearing loss (HL) are limited and often focus on individual PAH compounds. The present study aimed to explore the individual and combined effects of PAH exposure on hearing loss, with a focus on the mediating role of inflammatory blood cell markers.

Methods: This cross-sectional study included 1,409 participants from 3 cycles of the National Health and Nutrition Examination Survey (2001-2002, 2003-2004, and 2011-2012).

Fucoidan-derived carbon dots as nanopenetrants of blood-brain barrier for Parkinson's disease treatment.

Parkinson's Disease (PD) stands as a prevalent neurodegenerative disorder. However, current pharmacotherapies for PD face challenges due to inadequate penetration through the blood-brain barrier (BBB), posing limitations on their therapeutic efficacy. Considering the potential of negatively charged carbon dots (CDs) in retaining functional groups from precursor molecules and vertically crossing the BBB, this study focuses on the utilization of fucoidan (FD), a promising pharmaceutical candidate with neuroprotective effects on dopamine-active neurons, for the development of negatively charged CDs through a one-step hydrothermal method, aiming to achieve efficient BBB penetration for PD treatment.

Vitamin E protects dopaminergic neurons against manganese-induced neurotoxicity through stimulation of CHRM1 and KCNJ4.

Background: Manganese (Mn) overexposure can induce neurotoxicity and lead to manganism. Vitamin E (Vit E) has neuroprotective effects by acting as an ROS scavenger, preventing mitochondrial dysfunction and neuronal apoptosis. However, the effects of Vit E on Mn-induced nigrostriatal system lesions remains unknown.

Correlation between dietary theobromine intake and low cognitive performance in older adults in the United States: A cross-sectional study based on the National Health and Nutrition Examination Survey.

Background And Objectives: Few studies have investigated the effects of dietary theobromine intake on the cognitive performance of older adults. Therefore, we investigated these effects in older adults in the United States.

Methods And Study Design: In this cross-sectional study, we used data (2011-2014) from the National Health and Nutrition Examination Survey.

Association between mixed dioxin exposure and hyperuricemia in U.S. adults: A comparison of three statistical models.

Background: Previous studies on the relationship between dioxin exposures and hyperuricemia have usually been based on multi-chemical linear models. However, the complex nonlinear relationship and interaction between mixed dioxin exposures and hyperuricemia have seldom been studied. In this study, we applied three different statistical models to assess the joint effect of 12 dioxins on hyperuricemia.

Temporal Associations between Tri-Ponderal Mass Index and Blood Pressure in Chinese Children: A Cross-Lag Analysis.

Background: No longitudinal studies have explored the relationship between tri-ponderal mass index (TMI) and blood pressure (BP) in children. This study is aimed to investigate the temporal associations between TMI and BP among children in China. Methods: A longitudinal study was carried out with Chinese children from 2014 to 2019.