Epigenetic regulation of TNNT1 in gastrointestinal cancers prognostic implications and clinical significance.

Objectives: This study aims to investigate the expression profile and clinical significance of the Troponin T Type 1 (TNNT1) gene across various digestive system tumors. By elucidating the role of TNNT1 in tumor progression, we hope to establish its potential as a prognostic biomarker and therapeutic target.

Methods: We assessed the expression levels of TNNT1 by employing bioinformatics analyses, including differential gene expression analysis and survival analysis utilizing data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

Integrated multi-omics analysis of UL16-binding protein 2 as a prognostic and immunotherapy biomarker for colorectal cancer.

Background: UL16-binding protein 2 (ULBP2) is an important immune regulatory molecule involved in natural killer cell activation and tumor immune surveillance, although the specific role and clinical significance in colorectal cancer (CRC) require further exploration.

Methods: ULBP2 expression in CRC vs. normal tissues was analyzed using The Cancer Genome Atlas and the Gene Expression Omnibus databases, along with potential associations with clinicopathological features, while the diagnostic value was assessed with receiver operating characteristic (ROC) curves and the prognostic impact by Kaplan-Meier and Cox regression analyses.

Expression patterns of MCM8 in lung adenocarcinoma and its correlation with key biological processes.

Objective: Lung adenocarcinoma (LUAD) is one of the most common and lethal tumors. The identification of diagnostic and prognostic biomarkers is essential to improve patient prognosis and treatment outcomes.

Methods: The expression of minichromosome maintenance complex component 8 (MCM8) in 33 cancer types was analyzed using the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression.

Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers.

RAB3B is essential for the transportation and secretion within cells. Its increased expression is linked to the development and progression of various malignancies. However, understanding of RAB3B's involvement in carcinogenesis is mostly limited to specific cancer subtypes.

Situs Inversus Totalis on F-FDG PET/CT: A Case Report and a Literature Review.

A 62-year-old female patient with pathologically confirmed left lung small cell neuroendocrine carcinoma. The patient was referred to our positron emission tomography (PET)/CT center to look for possible metastatic diseases. After fasting for 8 h, the fasting blood glucose level of the patient was 7.

Comprehensive Analysis of Hexokinase 2 Immune Infiltrates and m6A Related Genes in Human Esophageal Carcinoma.

Hexokinase 2 not only plays a role in physiological function of human normal tissues and organs, but also plays a vital role in the process of glycolysis of tumor cells. However, there are few comprehensive studies on HK2 in esophageal carcinoma (ESCA) needs further study. Oncomine, Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database were used to analyze the expression differences of HK2 in Pan-cancer and ESCA cohort, and to analyze the correlation between HK2 expression level and clinicopathological features of TCGA ESCA samples.

Effects of miR-362 in Regulating the Proliferation, Invasion and Apoptosis of Gastric Cancer by Inhibiting the Expression of Tumor-Promoting Factor PRDM2.

Purpose - The high expression of positive regulatory domain zinc finger protein2 (PRDM2) is an important factor in inducing the formation and progression of gastric cancer. The current study was performed to explore the effect of micro-RNA-362 (miR-362) targeting PRDM2 on the proliferation and apoptosis of gastric cancer cells. Methods - The expression of miR-362 in gastric adenocarcinoma and normal gastric mucosa was detected by real-time fluorescence quantitative PCR (qPCR), and the expression of PRDM2 in gastric adenocarcinoma was detected by im-munohistochemical method.