A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.

Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. This data, for instance, can help address the lower than 50% response rates to cancer immunotherapy. However, current clinical imaging modalities lack the molecular contrast, resolution, and chronic usability for rapid and accurate response assessments.

Pain and Analgesic Use in Patients With Chronic Kidney Disease Not on Dialysis: A Systematic Review.

Background: Chronic pain is common in patients with chronic kidney disease (CKD), yet pain management in non-dialysis-dependent CKD (NDD-CKD) is underexplored. Inappropriate analgesic use poses significant risks in this population.

Objective: To evaluate patterns of analgesic use-specifically opioids and NSAIDs-and associated clinical characteristics in patients with NDD-CKD.

Spontaneous Anterolateral Papillary Muscle Rupture Complicated by Acute Torrential Mitral Regurgitation and Cardiogenic Shock: A Case Report.

Spontaneous papillary muscle rupture is a rare and life-threatening event. We present the case of a 70-year-old male who presented with shortness of breath and cough, with imaging findings consistent with flash bilateral pulmonary edema. Due to progressive respiratory failure and cardiogenic shock, he required emergent intubation and initiation of inotropic and vasopressor support.

Advancements in constructed wetland technology: a state-of-the-art review on bio-electrochemical processes, tidal flow dynamics, and resilience to shock loads.

This research article presents a comprehensive examination of recent advancements in constructed wetland technology, with a primary focus on bio-electrochemical processes, including electrolysis and microbial fuel cells, as well as the impact of tidal flow and shock loads on the constructed wetland performance. To date, extensive studies and in-depth analyses in these aspects are limited, highlighting a significant research gap. Electrolysis is explored for its efficacy in dephosphorization and denitrification, particularly under conditions of low carbon availability.

Unusual Presentation of Acute Gastrointestinal Bleeding in Gastric Lipoma and Concomitant Infection: A Case Report.

Active () infection may contribute to the ulceration and hemorrhage of otherwise benign gastric lipomas. This case highlights the utility of combining invasive and non-invasive testing of in bleeding gastric ulcers and emphasizes the critical role of testing and eradication in bleeding gastric lipomas.

Determining safe washout period for immune checkpoint inhibitors prior to liver transplantation: An international retrospective cohort study.

Background And Aims: Immune checkpoint inhibitors (ICIs) are increasingly used in patients with advanced HCC patients awaiting liver transplantation (LT). However, concerns about the risk of posttransplant rejection persist.

Approach And Results: We conducted an international retrospective cohort study including 119 HCC patients who received ICIs prior to LT.

Acute Myelomonocytic Leukemia: A Rare Cause of Painless Jaundice.

Acute myelomonocytic leukemia (AMML) is a rare and aggressive subtype of acute myeloid leukemia with varying clinical manifestations. Although hepatic involvement in AMML is commonly seen, cholestatic hepatitis as a primary manifestation of the disease is very rare. In the present case, our elderly patient presented with predominant signs of cholestasis, including jaundice, nausea, and vomiting.

Economic burden of inpatient hospitalizations for pediatric chronic kidney disease in the US.

Background: Children with chronic kidney disease (CKD) face extensive healthcare needs, leading to substantial financial strain on both families and healthcare systems due to costly kidney replacement therapies and associated comorbidities. Limited research on inpatient healthcare utilization is available for the individual stages of pediatric CKD.

Methods: This retrospective cohort study included inpatient encounters for pediatric patients (≤ 18 years) using the Pediatric Health Information System Database (PHIS) between January 2016 and December 2022, with an ICD-10 code for any CKD stage (1-5).

Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.

Background: Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn's disease (CD) remains limited.

Aim: To systematically review the global variation in the rates of surgery in CD.

Methods: A comprehensive search analysis was performed using multiple electronic databases from inception through July 1, 2020, to identify all full text, randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with CD.

A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.

Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. This data, for instance, can help address the lower than 50% response rates to cancer immunotherapy. However, current clinical imaging modalities lack the molecular contrast, resolution, and chronic usability for rapid and accurate response assessments.

Effect of islet alone or islets after kidney transplantation on quality of life in type 1 diabetes: A systematic review.

Background: Pancreatic islet transplantation for type 1 diabetes mellitus (T1DM) is efficacious in supressing severe hypoglycaemic episodes (SHE) and restoring glycaemic regulation, which are both pivotal in increasing health-related quality of life (HRQoL). Therefore, a systematic assessment of reports detailing HRQoL outcomes is warranted to better understand the benefits of islet transplantation. To this end, we performed a systematic review of the literature to assess the impact of islet transplantation on HRQoL in individuals with T1DM, whether as a standalone procedure (ITA) or following renal transplantation (IAK).

Assessment of Postoperative Swelling and Pain Following Alveolar Ridge Preservation with Different Biomaterials: A Randomized Controlled Trial.

Background: This randomized controlled trial aimed to assess and compare postoperative swelling and pain in patients undergoing alveolar ridge preservation using RidgeMax Pro and AlveoGraft Plus.

Methods: A total of 20 patients requiring tooth extraction were enrolled in this study and randomly assigned to two groups: Group A received alveolar ridge preservation with RidgeMax Pro and Group B with AlveoGraft Plus. Postoperative swelling was evaluated by measuring facial dimensions using standardized facial photographs at baseline and at 24, 48, and 72 hours postoperatively.

The prevalence, angiographic profile and clinical features, management, and outcomes of coronary artery perforation secondary to percutaneous coronary interventions in Pakistan: a retrospective cohort study.

Unlabelled: Coronary artery perforation (CAP) is a rare entity that is often fatal. The mortality rates reported as high as up to 21% hence prompt diagnosis, intervention, and treatment are paramount to survival for such patients. Several factors may predispose a patient to coronary artery intervention including chronic total occlusion, severe calcification and tortuosity, aggressive use of oversized balloons and stents, and use of athero-ablative devices.

Long-Term Usage of Oral Glucocorticoids Leading to Adrenal Insufficiency: A Comprehensive Review of the Literature.

Systemic glucocorticoid therapy is used worldwide by one to three percent of the general population and 0.5-1.8% on long-term oral glucocorticoid use.

How do psychobehavioural variables shed light on heterogeneity in COVID-19 vaccine acceptance? Evidence from United States general population surveys on a probability panel and social media.

Objectives: To (1) understand what behaviours, beliefs, demographics and structural factors predict US adults' intention to get a COVID-19 vaccination, (2) identify segments of the population ('personas') who share similar factors predicting vaccination intention, (3) create a 'typing tool' to predict which persona people belong to and (4) track changes in the distribution of personas over time and across the USA.

Design: Three surveys: two on a probability-based household panel (NORC's AmeriSpeak) and one on Facebook.

Setting: The first two surveys were conducted in January 2021 and March 2021 when the COVID-19 vaccine had just been made available in the USA.

Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis.

Testosterone replacement therapy (TRT) has been used to treat hypogonadal males with type 2 diabetes mellitus (T2DM) for a long time, despite variable results. This meta-analysis examines TRT's role in hypogonadal males with T2DM. The databases PubMed, Embase, and Google Scholar were searched for relevant RCTs and observational studies.

Implant-Supported Overdenture Using Ball Attachments in Maxilla and Mandible: A Case Report.

Implant-supported overdentures are advantageous over conventional dentures, as they improve patient esthetics and enable retention, stability, comfort, and psychological well-being of the patient. This article describes a simple chairside technique for loading maxillary and mandibular dentures onto implant ball attachments.

A meta-analysis: incidental intraductal papillary mucinous neoplasm and extra-pancreatic malignancy.

Introduction: Meta-analysis aimed to quantify the relationship between intraductal papillary mucinous neoplasm (IPMN) and increased incidence of extra-pancreatic malignancy (EPM) previously reported in qualitative observational cohort studies.

Methods: Study protocol was registered with PROSPERO (CRD42020169614) and conducted to the Meta-analysis Of Observational Studies in Epidemiology and systematic review reported with Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Assessing the Methodological Quality of Systematic Reviews guidelines.

Results: Sixteen studies (total of 8240 patients) were included in the pooled, and 7399 patients in the subgroup meta-analyses.

A comparison of the inflammatory response following autologous compared with allogenic islet cell transplantation.

Background: The initial response to islet transplantation and the subsequent acute inflammation is responsible for significant attrition of islets following both autologous and allogenic procedures. This multicentre study compares this inflammatory response using cytokine profiles and complement activation.

Methods: Inflammatory cytokine and complement pathway activity were examined in two cohorts of patients undergoing total pancreatectomy followed either by autologous (n=11) or allogenic (n=6) islet transplantation.

Diagnostic Challenges in Canine Parvovirus 2c in Vaccine Failure Cases.

In this study, three different diagnostic tests for parvovirus were compared with vaccination status and parvovirus genotype in suspected canine parvovirus cases. Faecal samples from vaccinated (N17) and unvaccinated or unknown vaccination status (N41) dogs that had clinical signs of parvovirus infection were tested using three different assays of antigen tests, conventional and quantitative PCR tests. The genotype of each sample was determined by sequencing.

Pilot study: deficiency of mannose-binding lectin-dependent lectin pathway, a novel modulator in outcome from pancreatic islet auto-transplantation.

Background: Numerous factors influence pancreatic islet survival following auto-transplantation. Of these, the host immune response in the early peri-operative period is one of the most important. In this study we investigated the role of the mannose-binding lectin (MBL)-dependent pathway in a group of total pancreatectomy (TP) islet auto-transplantation (TPIAT) patients and classified them as competent or deficient in MBL activity.

Adherence to Levothyroxine Tablet in Patients with Hypothyroidism.

Introduction Patients with hypothyroidism are managed with life-long levothyroxine (LT4) therapy. However, as with other chronic illnesses, drug adherence (DA) is a prominent issue in these patients. The aim of this study is to identify the extent of DA to LT4 in hypothyroidism patients and study the clinical factors contributing to DA in these patients.

An ex vivo porcine spleen perfusion as a model of bacterial sepsis.

An ex vivo, porcine spleen perfusion model was established to study the early events occurring in the spleen prior to the onset of bacterial sepsis, using organs retrieved from animals slaughtered for food production. Porcine spleens were harvested from adult pigs and connected to a normothermic extracorporeal perfusion circuit. A constant perfusion of heparinized blood was performed for 6 hours.

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.

Chemical strategies to block quorum sensing (QS) could provide a route to attenuate virulence in bacterial pathogens. Considerable research has focused on this approach in Pseudomonas aeruginosa, which uses the LuxR-type receptor LasR to regulate much of its QS network. Non-native ligands that antagonize LasR have been developed, yet we have little understanding of the mode by which these compounds interact with LasR and alter its function, as the receptor is unstable in their presence.