Exploring thoracic aorta ECM alterations in Marfan syndrome: insights into aorta wall structure.

Marfan syndrome is a connective tissue disorder caused by FBN1 mutations, leading to aortic wall fragility and increased susceptibility to aneurysm and dissection. This study investigated microstructural and molecular alterations in the thoracic aorta of Fbn1mgΔ mice, with a focus on the tunica intima and media. Histological and ultrastructural analyses demonstrated elastic fiber fragmentation and reduced fibrillin-1 expression.

Overview of different reimbursement strategies among contrast-enhanced mammography (CEM) expert centers on a global level - A survey study.

Objectives: To perform an international survey among global expert breast radiologists regarding contrast-enhanced mammography (CEM) on the topic of reimbursement strategies.

Methods: An online questionnaire on CEM reimbursement strategies was distributed to 29 selected global expert breast radiologists regarding CEM. Hospital information, CEM implementation, estimated costs, reimbursement availability, registration and declaration codes, as well as personal opinions on CEM reimbursement, were collected.

Structural Evolution in Tin Chloride through Neutron Irradiation: Toward Indium-Doped Tin.

This study examines the feasibility of neutron-induced nuclear transmutation for producing indium-doped tin materials using SnCl as a model system. Neutron irradiation resulted in structural modifications, including morphological changes, lattice expansion, and the formation of indium-containing crystalline phases. Scanning Electron Microscopy (SEM) and Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) confirmed the presence of indium at approximately 0.

Periodontal Health in Individuals Living with HIV: An Exploratory and Descriptive Molecular Approach of Microbial Interspecific and Intraspecific Diversity in Brazilian Patients.

Oral manifestations of HIV infection can be an early sign of the disease and may indicate progression to AIDS. Although antiretroviral therapies, especially highly active antiretroviral therapy (HAART), have reduced the prevalence of HIV-related oral lesions, ongoing updates in diagnosis and treatment are essential due to the extended life expectancy of individuals living with HIV. Periodontal disease is a significant concern in these patients, influenced by altered immune responses and microbial dynamics, though the mechanisms are not fully understood.

The implications of hyperekplexia on children's quality of life: a report on two cases.

Objective: To report two pediatric cases of hyperekplexia in a small city of São Paulo state, Brazil.

Case Description: Two female patients, one aged three years and six months and one aged five months, receiving care from an APAE (Association of Parents and Friends of People with Disabilities) unit, were diagnosed with hyperekplexia 1, a neurological disorder characterized by an excessive startle response. Hyperekplexia cases can be divided into three subgroups: hereditary, sporadic, and symptomatic.

Increased arterial stiffness in normotensive individuals with hypoparathyroidism.

Hypoparathyroidism is the inability of parathyroid hormone (PTH) to maintain calcium homeostasis. Patients with post-surgical hypoparathyroidism may have an increased risk of mortality; there is clinical and molecular evidence of the effects of this condition on the cardiovascular system. The aim of this study was to evaluate arterial stiffness by measuring the carotid-femoral pulse wave velocity (PWV) in post-surgical hypoparathyroidism patients.

Effect of print layer thickness and finishing and polishing protocols on the flexural strength, cell adhesion, and surface properties of a 3D printed resin.

Statement Of Problem: Evidence regarding standardization of finishing and polishing protocols for 3-dimensionally (3D) printed interim resins is sparse.

Purpose: The purpose of this in vitro study was to evaluate the influence of print layer thickness and aging on the flexural strength, cell adhesion, and surface roughness of a 3D printed resin for interim crowns submitted to different finishing and polishing protocols.

Material And Methods: A total of 150 bars were printed (Flash Forge Foto 6.

Exploring lipase regioselectivity: synthesis of regioisomeric acetoxyhydroxynaphthalenes.

The naphthalene ring is a moiety featured by many bioactive agents. Dihydroxynaphthalenes are readily available substances but their use for the synthesis of a series of compounds results in limited chemical diversity due to the similar reactivity of the phenolic hydroxyl groups. Herein, we describe the use of regioselective lipases in acylation and hydrolysis reactions to synthesize 5 different regioisomeric acetoxyhydroxynaphthalenes on a 91-122 mg scale with moderate to good yields (50-78%) from 1,3-, 1,6- and 1,7-dihydroxynaphthalenes and their corresponding diacetates.

Effect of different finishing/polishing techniques and glaze application on the flexural strength of ultratranslucent zirconia after hydrothermal aging.

Purpose: To evaluate the effect of different finishing/polishing procedures and glaze on the surface roughness, flexure strength, and microstructure of an ultratranslucent zirconia (UZ) submitted aging.

Methodology: Two hundred and forty (240) UZ bars were sintered (8 × 2 × 1 mm) and treated according to the factors (n = 15): Type of finishing/polishing procedure (Control - Ctrl; Ultra-fine Diamond Burr - FG; Medium grit diamond burr- MG; Stone Bur - Stone; Rubber - Rub; FG + Rub; MG + Rub; Stone + Rub), and "Glaze" (Without and With - Gl). The bars were hydrothermally degraded (24 h, 127 °C, 1.

Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study.

Purpose: A survey conducted by the European Society of Breast Imaging (EUSOBI) in 2023 revealed significant variations in Quality Assurance (QA) practices across Europe. The UK encourages regular performance monitoring for screen readers. This study aimed to assess the variability in diagnostic performance among readers participating in a wider prospective randomised trial across multiple countries.

Extreme droughts in the Amazon Basin during cyclic ENSO events coupled with Indian Ocean Dipole modes and Tropical North Atlantic warming.

The teleconnections between El Niño-Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), and Tropical North Atlantic warming (+TNA) play a critical role in characterizing extreme drought events in the Amazon Basin (AB). This study examines the seven most recent drought extreme events up to 2023, using seasonal composites of the sea surface temperature and atmospheric variables over a five-quarter period starting at the austral spring(-1) of the year preceding that when the lowest water level at Manaus port was recorded. Two distinct patterns emerge, driven by consecutive ENSO events with opposite phases, referred to as cyclic La Niña-El Niño and cyclic El Niño-La Niña drought events.

Constructing tridimensional modeling and radiographic evaluation of diaphyseal fractures in a canine femur for veterinary education.

Purpose: To create tridimensional (3D) anatomical models of diaphyseal fractures in dogs (3D AMDFD) and to evaluate the models from their radiographs.

Methods: The study consisted of six stages: preparation of femur from a healthy dog cadaver; digitalization of the bone through a 3D scanner and creation of the base model; creation of a 3D AMDFD based on the image of the base model, 3D modeling carried out to reproduce five different types of diaphyseal fractures; printing the models produced on a 3D printer with a thermoplastic material; insertion of neodymium magnets in the fracture line to allow the assembly and disassembly of the parts; and radiography of 3D AMDFD in lateromedial and craniocaudal positions.

Results: The base model and 3D AMDFD had high precision in the replication of bone structures, like the bone in natura.

Repair bond strength of resin composite to CAD/CAM glass-ceramic: Influence of cleaning methods, surface treatments, and aging.

Objective: To evaluate the influence of different cleaning methods, surface treatments, and aging on the repair bond strength to a CAD/CAM glass-ceramic.

Materials And Methods: Forty-eight lithium disilicate CAD/CAM ceramic blocks were fabricated, sintered, and embedded in acrylic resin. After contamination with human saliva, they were divided according to the factors "Cleaning method" (Control-water/air spray, Air-particle abrasion with AlO, Ivoclean cleaning paste), "Surface treatment" (5 % Hydrofluoric acid-HF + Silane, Monobond Etch & Prime-MEP), and "Aging" (thermocycling, no thermocycling).

Combining Photochemical Oxyfunctionalization and Enzymatic Catalysis for the Synthesis of Chiral Pyrrolidines and Azepanes.

Chiral heterocyclic alcohols and amines are frequently used building blocks in the synthesis of fine chemicals and pharmaceuticals. Herein, we report a one-pot photoenzymatic synthesis route for -Boc-3-amino/hydroxy-pyrrolidine and -Boc-4-amino/hydroxy-azepane with up to 90% conversions and >99% enantiomeric excess. The transformation combines a photochemical oxyfunctionalization favored for distal C-H positions with a stereoselective enzymatic transamination or carbonyl reduction step.

A comprehensive review of non-invasive optical and microwave biosensors for glucose monitoring.

Frequent glucose monitoring is essential for effective diabetes management. Currently, glucose monitoring is done using invasive methods such as finger-pricking and subcutaneous sensing. However, these methods can cause discomfort, heighten the risk of infection, and some sensing devices need frequent calibration.

Multilayer Ultratranslucent Monolithic Zirconia Crowns Treated With Multimode Universal Adhesive System Containing Zirconia Primer: A Clinical Report.

Introduction: Ultratranslucent zirconia combines high mechanical strength and esthetics, making it ideal for monolithic restorations. This case report describes a total rehabilitation of the upper dental arch with single-unit crowns made of multilayer ultratranslucent zirconia (Prettau 4 Anterior, Zirkonzahn), as well as the use of a simplified adhesive cementation protocol for this type of ceramic.

Materials And Methods: A 64-year-old female patient sought rehabilitative treatment, after planning in a semi-adjustable articulator, interim prostheses, from tooth 2 to 15, were installed to restore occlusal vertical dimension and esthetics.

Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.

Background: Plasmodium vivax infection, when it occurs during pregnancy, has often been associated with serious adverse pregnancy outcomes. However, immunological alterations in pregnancy and their consequences have been little explored. We characterized the humoral immune response in pregnant women exposed to malaria by P.

Levoglucosenone as a starting material for cascade continuous-flow synthesis of (R)-γ-carboxy-γ-butyrolactone.

The global imperative to shift towards renewable and sustainable resources has spurred significant interest in exploring and utilizing platform chemicals derived from renewable feedstocks. Among these, levoglucosenone (LGO) and Cyrene™ have emerged as promising candidates. LGO, derived from the pyrolysis of cellulose and hemicellulose, exhibits structural versatility, making it an attractive starting material for various valuable products.

Development of a novel and useful methodology for the simultaneous analysis of multiclass contaminants in bovine fat.

The instrumental development of tandem mass spectrometers fosters the actual trend in the trace analysis of organic compounds to the development of methods that allow the analysis of contaminants of the most diverse origin in a single analytical sample. The multiclass methods are aligned with the Who's One Health initiative while accomplishing the concepts of green chemistry. However, there are few reports of wide scope multiclass methods for the analysis of contaminants in this matrix.

Effect of cementation protocols on the fracture load of bilayer ceramic crowns manufactured by the Rapid Layer Technology.

To evaluate the fracture load of bilayer ceramic crowns manufactured by Rapid Layer Technology (RLT) after different cementation protocols of the veneering ceramic to the zirconia infrastructures. Sixty epoxy resin preparations simulating a molar tooth were obtained and 60 zirconia infrastructures and feldspathic crowns were manufactured by RLT and divided into 6 groups according to the cementation protocol at the interface to veneering ceramic (n=10): Ctr- control: conventional resin cement; Al- Al2O3 sandblasting 50µm + conventional resin cement; Al/MDP- Al2O3 sandblasting (50µm) + resin cement with MDP; Sil- silicatization 30µm + conventional resin cement; Gl/HF- glaze + hydrofluoridric acid (5%,60s) + silane + conventional resin cement; Gl- glazing as bonding agent. The feldspathic ceramic internal surface was etched with fluoridric acid (5%) + silane followed by cementation according to respective protocols.

Effect of different surface treatments and adhesive cementation on the surface topography and flexural strength of translucent and ultra-translucent monolithic zirconia.

Purpose: To evaluate the effect of different surface treatments and adhesive cementation on the miniflexural strength (MFS) of monolithic zirconia.

Materials And Methods: Two-hundred and forty (240) sintered bars of translucent zirconia (Z) and ultra-translucent zirconia (Z) were obtained (8 mm ×2 mm ×1 mm). The bars were divided into 16 groups (n = 15) according to the factors "Zirconia" (Z and Z), "Cementation" (Cem) and "surface treatment" (Ctrl:Control, Al:Aluminum oxide/AlO 50 µm, Si:Silica/SiO coated alumina particles oxide 30 µm, Gl:Glazing+hydrofluoric acid).