A lysosomal surveillance response to stress extends healthspan.

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%.

NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.

Mitochondria are known as the powerhouse of the cell. Dysfunction of mitochondria homeostasis induces the mitochondrial unfolded protein response (UPR), altering cellular metabolism. How cells sense the UPR to rewire metabolism is largely unknown.

mmBCFA C17iso ensures endoplasmic reticulum integrity for lipid droplet growth.

In eukaryote cells, lipid droplets (LDs) are key intracellular organelles that dynamically regulate cellular energy homeostasis. LDs originate from the ER and continuously contact the ER during their growth. How the ER affects LD growth is largely unknown.

A Large-Scale Serological Survey of Infection Among Persons Participated in Health Screening in Yunnan Province, Southwestern China.

Surveys of infection in animals have been reported in Yunnan province, southwestern China. However, limited information is available regarding the epidemiology of infection among persons participated in health screening in Yunnan. From January 2014 to December 2016, a large-scale and cross-sectional serological survey was conducted to reveal the seroprevalence of infection in persons participated in health screening in three major hospitals.