The influence of microwave ablation parameters on the positioning of trocar in different cancerous tissues: a numerical study.

The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results.

Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro.

Organs-on-chips have been tissues or three-dimensional (3D) mini-organs that comprise numerous cell types and have been produced on microfluidic chips to imitate the complicated structures and interactions of diverse cell types and organs under controlled circumstances. Several morphological and physiological distinctions exist between traditional 2D cultures, animal models, and the growing popular 3D cultures. On the other hand, animal models might not accurately simulate human toxicity because of physiological variations and interspecies metabolic capability.

In-Silico Analysis of Optimal Configurations for Rotational Bioinspired Bone Marrow Biopsy Needle Designs: An ANN Approach.

Medical needle innovations have utilized rotating motion to enhance tissue-cutting capabilities, reducing cutting force and improving clinical outcomes. This study analyzes the effects of six essential factors on insertion and extraction forces during bone marrow biopsy (BMB) procedures. The study uses Taguchi's L32 orthogonal array and numerically simulates the BMB process using the Lagrangian surface-based method on a three-dimensional (3D) heterogeneous Finite Element (FE) model of the human iliac crest.

A prospective survey on trephine biopsy of bone and bone marrow: an experience with 274 Indian patients' biopsies.

Trephine bone marrow biopsy is an effective technique for diagnosing hematological malignancies in patients of different ages. During trephine biopsy, bone marrow cores are obtained for detailed morphological evaluation to look for any abnormality and arrive at a diagnosis. The primary goal of this work is to perform a survey on Indian patients of various ages for the trephine bone marrow biopsy process.

Safety and efficacy of intracavitary microwave ablation in hepatic gland tumours: Numerical and in vitro studies.

The microwave ablation (MWA) of large hepatic gland tumour using multiple trocars operated at 2.45/6 GHz frequencies has been analysed. The ablation region (in vitro) obtained using parallel and non-parallel insertion of multiple trocars into the tissue has been analysed and compared with the numerical studies.

Honeybee stinger-based biopsy needle and influence of the barbs on needle forces during insertion/extraction into the iliac crest: A multilayer finite element approach.

Bone marrow biopsy (BMB) needles are frequently used in medical procedures, including extracting biological tissue to identify specific lesions or abnormalities discovered during a medical examination or a radiological scan. The forces applied by the needle during the cutting operation significantly impact the sample quality. Excessive needle insertion force and possible deflection might cause tissue damage, compromising the integrity of the biopsy specimen.

Simulating radiofrequency ablation of hepatocellular carcinomas proximal to bare area of liver.

Purpose: To numerically assess the significance of dextrose 5% in water (D5W) thermo-protection during radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs) located near the 'bare area of liver'.

Material And Methods: This study utilises quasi-anatomical structures extracted from CT images. A multi-tine electrode, deployed inside the extracted organs and operated under temperature-controlled mode was used as the source of ablation.

Microwave ablation trocar for ablating cancerous tumors: a numerical analysis.

Microwave ablation (MWA) is a newly developing minimally invasive thermal therapies technology. The ablation region obtained during MWA mainly depends on the type and efficiency of the trocar as well as the energy transfer from the generator to the biological tissue. In the present article, a novel trocar for MWA therapies has been proposed.

Finite element simulation of multilayer model to simulate fine needle insertion mechanism into iliac crest for bone marrow biopsy.

The main aim of this work is to use a finite element technique (FEM) to gain understanding about the bone marrow biopsy (BMB) needle insertion process and needle-tissue interactions in the human iliac crest. A multi-layer iliac crest model consists of stratum corneum, dermis, epidermis, hypodermis, cortical, and cancellous bone has been established. This paper proposes a FE model that examines all phases of tissue deformation, including puncture, cutting, needle-tissue interaction, and various stress-strain values for BMB needle during interaction.

Directional ablation in radiofrequency ablation using a multi-tine electrode functioning in multipolar mode: An in-silico study using a finite set of states.

Purpose: To analyse the feasibility of directional ablation using a multi-tine electrode.

Methods: A multi-tine electrode capable of operating in multipolar mode has been used to study the directional ablation. In addition to the basic design, similar to commercially available FDA approved multi-tine electrode, tines have been insulated from each other inside the probe base and tip using a thin insulating material of thickness 0.

Numerical study to establish relationship between coagulation volume and target tip temperature during temperature-controlled radiofrequency ablation.

The present study aims at proposing a relationship between the coagulation volume and the target tip temperature in different tissues (viz., liver, lung, kidney, and breast) during temperature-controlled radiofrequency ablation (RFA). A 20-min RFA has been modelled using commercially available monopolar multi-tine electrode subjected to different target tip temperatures that varied from 70°C to 100°C with an increment of 10°C.

Temperature-controlled radiofrequency ablation of different tissues using two-compartment models.

Purpose: This study aims to analyse the efficacy of temperature-controlled radiofrequency ablation (RFA) in different tissues.

Materials And Methods: A three-dimensional, 12 cm cubical model representing the healthy tissue has been studied in which spherical tumour of 2.5 cm has been embedded.

Thermal analysis of induced damage to the healthy cell during RFA of breast tumor.

Effective pre-clinical computational modeling strategies have been demonstrated in this article to enable risk free clinical application of radiofrequency ablation (RFA) of breast tumor. The present study (a) determines various optimal regulating parameters required for RFA of tumor and (b) introduces an essential clinical monitoring scheme to minimize the extent of damage to the healthy cell during RFA of tumor. The therapeutic capabilities offered by RFA of breast tumor, viz.

Suitability of frequency modulated thermal wave imaging for skin cancer detection-A theoretical prediction.

A theoretical study on the quantification of surface thermal response of cancerous human skin using the frequency modulated thermal wave imaging (FMTWI) technique has been presented in this article. For the first time, the use of the FMTWI technique for the detection and the differentiation of skin cancer has been demonstrated in this article. A three dimensional multilayered skin has been considered with the counter-current blood vessels in individual skin layers along with different stages of cancerous lesions based on geometrical, thermal and physical parameters available in the literature.

Thermographic evaluation of early melanoma within the vascularized skin using combined non-Newtonian blood flow and bioheat models.

A theoretical study on vascularized skin model to predict the thermal evaluation criteria of early melanoma using the dynamic thermal imaging technique is presented in this article. Thermographic evaluation of melanoma has been carried out during the thermal recovery of skin from undercooled condition. During thermal recovery, the skin has been exposed to natural convection, radiation, and evaporation.