Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study.

The potential of the phytoconstituent, curcumin, as an adjuvant to chemoradiotherapy has been investigated because of its ameliorating effects, including the sensitization of cancer and cancer stem cells. Curcumin, a strong antioxidant with pharmacologically non-toxic effects, can be used as an adjuvant with enhanced bioavailability and administered along with chemotherapy to achieve better treatment outcomes. The present study was carried out with a total of 120 women with locally advanced/metastatic breast cancer, who were randomized to receive standard chemotherapy alone or chemotherapy with oral curcumin, a 500 mg capsule (1 g/day) containing 95% curcuminoid and 1% piperine given for 12 to 24 weeks.

A pentatricopeptide repeat protein restores fertility in Moricandia arvensis based cytoplasmic male sterility system in Brassica juncea.

An introgression from Moricandia arvensis is known to restore male fertility to Brassica juncea cytoplasmic male sterile lines carrying M. arvensis, Diplotaxis berthautii, D. catholica or D.

BgDB: a comprehensive genomic resource information system of bitter gourd for accelerated breeding programme.

Bitter gourd, scientifically known as Momordica charantia L. with 2n = 22, is a widely recognized medicinal vegetable, renowned for its multifaceted health benefits, primarily acclaimed for its lipid- and glucose-lowering effects. Its growing demands as a food source and for industrial applications necessitate value addition in ongoing breeding initiatives to enhance genotypic traits in multifarious ways.

The Triglyceride-Glucose Index: A Novel Marker for Clinical Atherosclerotic Cardiovascular Disease Risk Stratification.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide with a substantial economic burden. It is driven by the intricate pathophysiology of insulin resistance (IR), which has been shown to disrupt glucose and lipid metabolism, vascular function, and drive inflammatory pathways, further accelerating the development and progression of CVD. The triglyceride-glucose (TyG) index, which was first proposed in 2008, has demonstrated strong correlations with the more traditional markers reserved for research settings, namely the hyperglycemic-euglycemic clamp and the homeostatic model assessment of IR.

A prospective, observational study of non-invasive venous waveform analysis (NIVA) for the detection of acute low volume blood loss in humans.

Background: Accurate non-invasive monitoring for the diagnosis of hemorrhage is an unmet need in acute care settings. Non-Invasive Venous waveform Analysis (NIVA) has demonstrated significant sensitivity in detecting acute hemorrhage with 8-10 % blood volume loss. To determine whether NIVA can accurately and non-invasively detect lower volumes of blood loss, we performed a prospective observational study using a digital blood volume monitor at an American Red Cross (ARC) donation center to assess NIVA's performance at lower blood volume loss.

Deciphering the transcriptional alterations in high grade serous ovarian cancer upon catalytic inactivation of protein kinase D.

Objectives: To study the transcription alterations in high grade serous ovarian cancer upon catalytic inactivation of protein kinase D (PKD).

Methods: PKD was catalytically inactivated in HGSOC cells OVCAR8 and SKOV3 by two highly selective, small molecule inhibitors CRT0066101, kb-NB142-70 and RNASeq analysis was performed to identify genes being differentially expressed upon this treatment. Gene Ontology and pathway analysis of the significantly differentially expressed transcripts were performed to identify the enriched biological process, molecular functions, and pathways.

From Inflamed Gums to Infected Heart: Linking Periodontal Diseases and Myocardial Infarction.

Periodontal disease is a chronic inflammatory condition that affects the tissues that support the teeth. It has been linked with various systemic conditions such as cardiovascular disorders, respiratory conditions, and diabetes, reinforcing the concept of oral-systemic hygiene. With its high prevalence and significant economic burden, periodontal disease has become a critical public health concern, impacting 11.

Multimodal machine learning for deception detection using behavioral and physiological data.

Deception detection is crucial in domains like national security, privacy, judiciary, and courtroom trials. Differentiating truth from lies is inherently challenging due to many complex, diversified behavioural, physiological and cognitive aspects. Traditional lie detector tests (polygraphs) have been widely used but remain controversial due to scientific, ethical, and practical concerns.

Deciphering the transcriptional alterations in high grade serous ovarian cancer upon catalytic inactivation of protein kinase D.

Objectives: To study the transcription alterations in high grade serous ovarian cancer upon catalytic inactivation of protein kinase D (PKD).

Methods: PKD was catalytically inactivated in HGSOC cells OVCAR8 and SKOV3 by two highly selective, small molecule inhibitors CRT0066101, kb-NB142-70 and RNASeq analysis was performed to identify genes being differentially expressed upon this treatment. Gene Ontology and pathway analysis of the significantly differentially expressed transcripts were performed to identify the enriched biological process, molecular functions, and pathways.

Experimental and computational kinetic evaluations of silver(I)-catalyzed oxidation of -chlorophenol by hexacyanoferrate(III): exploring the mechanistic pathway.

The present investigation delves into the redox reaction between -chlorophenol (-CP) and hexacyanoferrate(III) [HCF(III)], catalyzed by Ag(I) in an alkaline environment. Findings reveal a first-order dependence on both -CP and the oxidant, and the reaction rate showcased a first-order reaction towards Ag(I), which was further amplified by the medium as per the equation = + [OH]. Interestingly, the ionic strength remained unchanged throughout the reaction, exerting no discernible effect on the reaction rate.

Efficient Formation of Secondary Organic Aerosols from the Aqueous Oxidation of Terpenoic 1,2-Diols by OH.

Aqueous oxidation of pinanediol (PND) and camphanediol (CND) by hydroxyl radical (OH) was investigated using gas and liquid chromatography coupled with mass spectrometry. The yields of the products formed were measured with authentic and surrogate standards. This approach quantified >97% of the products for both reactions under investigation.

Effect of a Structured Tele Based Post COVID-19 Rehabilitation Program in the Indian Population.

The emergence of coronavirus disease of 2019 (COVID-19) and the imperative for social distancing have propelled telehealth to the forefront. Even after discharge, patients may experience lingering symptoms, termed post-COVID-19 syndrome, which impairs functioning. This syndrome persists beyond recovery from COVID-19.

Optimizing Glioblastoma, IDH-wildtype Treatment Outcomes : A Radiomics and Support Vector Machine-Based Approach to Overall Survival Estimation.

Objective: Glioblastoma multiforme (GBM), particularly the isocitrate dehydrogenase (IDH)-wildtype type, represents a significant clinical challenge due to its aggressive nature and poor prognosis. Despite advancements in medical imaging and its modalities, survival rates have not improved significantly, demanding innovative treatment planning and outcome prediction approaches.

Methods: This study utilizes a support vector machine (SVM) classifier using radiomics features to predict the overall survival (OS) of GBM, IDH-wildtype patients to short (<12 months) and long (≥12 months) survivors.

Serine hydroxymethyltransferase6 is involved in growth and resistance against pathogens via ethylene and lignin production in Arabidopsis.

Photorespiratory serine hydroxymethyltransferases (SHMTs) are important enzymes of cellular one-carbon metabolism. In this study, we investigated the potential role of SHMT6 in Arabidopsis thaliana. We found that SHMT6 is localized in the nucleus and expressed in different tissues during development.

Recent breakthroughs in understanding the cerebellum's role in fetal alcohol spectrum disorder: A systematic review.

Exposure to alcohol during fetal development can lead to structural and functional abnormalities in the cerebellum, a brain region responsible for motor coordination, balance, and specific cognitive functions. In this systematic review, we comprehensively analyze a vast body of research conducted on vertebrate animals and humans over the past 13 years. We identified studies through PubMed and screened them following PRISMA guidelines.

Variants in exon 2 of MED12 gene causes uterine leiomyoma's through over-expression of MMP-9 of ECM pathway.

Aims: To study the impact of Mediator complex subunit 12 (MED12) gene variants on the encoded protein's function and pathogenic relevance for genesis of uterine leiomyoma's (ULs).

Methods: Mutational analysis in exon-2 of MED12 gene was performed by PCR amplification and DNA sequencing in 89 clinically diagnosed ULs tissues. Pathogenicity prediction of variation was performed by computational analysis.

Improving Access to Eye Care in Rural Communities: PocDoc's Web-Based Visual Acuity Screening Tool.

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Gender parity in high impact neurology journals.

Background: Although female representation has been growing among physicians, women continue to be underrepresented in neurology, particularly regarding academic research in authorship and leadership. Analyzing recent trends in high-impact neurology journals highlights the underrepresentation of women and helps explore barriers to female representation in academic neurology.

Methods And Results: Journal Citation Reports (JCR) for 2021 was used to screen neurology journals for selection.

Comparative assessment of surface irregularities of enamel after bonding with different techniques followed by three composite removal methods: An atomic force microscopic study.

Background: To compare and assess the enamel surface roughness by Atomic Force Microscopy between ceramic and metal brackets after adhesive removal with 3 different methods.

Methods: 90 extracted premolars were collected and divided equally into 3 groups G, Y, and R. With group G bonded with metallic brackets (using primer and Transbond XT), group Y with ceramic brackets (primer and Transbond XT), and group R with ceramic brackets (silane and Transbond XT).

Machine learning for cognitive behavioral analysis: datasets, methods, paradigms, and research directions.

Human behaviour reflects cognitive abilities. Human cognition is fundamentally linked to the different experiences or characteristics of consciousness/emotions, such as joy, grief, anger, etc., which assists in effective communication with others.

Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics.

Cyclooxygenase-2 (COX-2) is the key enzyme responsible for the conversion of arachidonic acid to prostaglandins that display pro-inflammatory properties and thus, it is a potential target protein to develop anti-inflammatory drugs. In this study, chemical and bio-informatics approaches have been employed to find a novel potent andrographolide (AGP) analog as a COX-2 inhibitor having better pharmacological properties than aspirin and rofecoxib (controls). The full amino acid sequenced human Alpha fold (AF) COX-2 protein (604AA) was selected and validated for its accuracy against the reported COX-2 protein structures (PDB ID: 5F19, 5KIR, 5F1A, 5IKQ and 1V0X) followed by multiple sequence alignment analysis to establish the sequence conservation.

Raman Evidence of Multiple Adsorption Sites and Structural Transformation in ZIF-4.

The zeolitic imidazolate framework, ZIF-4, exhibits soft porosity and is known to show pore volume changes with temperatures, pressures, and guest adsorption. However, the mechanism and adsorption behavior of ZIF-4 are not completely understood. In this work, we report an open to narrow pore transition in ZIF-4 around ∼ 253 K upon lowering the temperature under vacuum (10 Torr) conditions, facilitated by C-H···π interactions.