Publications by authors named "Floyd D Silva"

The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. Here we show that in male mice, a population of transcription factor jun-B (JunB)-enriched (JunB) adipocytes within the brown adipose tissue exhibits lower thermogenic capacity compared to high-thermogenic adipocytes.

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Background: Although female representation has been growing among physicians, women continue to be underrepresented in neurology, particularly regarding academic research in authorship and leadership. Analyzing recent trends in high-impact neurology journals highlights the underrepresentation of women and helps explore barriers to female representation in academic neurology.

Methods And Results: Journal Citation Reports (JCR) for 2021 was used to screen neurology journals for selection.

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Background: There are very few documented reports in literature of cerebral venous sinus thrombosis (CVST) caused by immune-mediated heparin-induced thrombocytopenia (HIT). Further, there are very few reports of false negative serotonin release assays (SRAs) when testing for immune-mediated HIT.

Case Presentation: We present a case of a 60- year-old male with recent unfractionated heparin administration for venous thromboembolism prophylaxis, an elevated 4T score of 5 and acute CVST in which immune-mediated HIT was suspected.

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Synopsis of recent research by authors named "Floyd D Silva"

  • - Floyd D Silva's recent research primarily explores the intersection of metabolic health, gender representation in neurology, and complex case presentations in hematology.
  • - In the study on adipocyte thermogenic capacity, Silva reveals the role of the transcription factor JunB in regulating thermogenic heterogeneity within brown adipose tissue, with implications for obesity and insulin resistance.
  • - Silva also addresses the underrepresentation of women in high-impact neurology journals and highlights the need for increased female representation and leadership within the field, while contributing to a rare case study of cerebral venous sinus thrombosis linked to heparin-induced thrombocytopenia.