Geochemical characterization of heavy metal bearing phases in the sediments of Ganges, India: analyzing the toxicity status of sedimentary environment.

The present study characterizes the heavy metal contamination in the bottom sediments of the Ganga River and the toxicity status of the associated aquatic environment. Cd was identified as a heavy metal of substantial concern, with levels surpassing baseline values, showing the effect of anthropogenic factors such as untreated urban-industrial wastewater and runoff from agricultural regions, among other local causes. The grain size distribution reveals that sediments contain dominant sand fractions (up to 60%), followed by silt and a small percentage of clay fractions.

Ultrafast Two-Dimensional Infrared Spectroscopy and Molecular Dynamics Simulations Reveal Slow Water Dynamics in Sulfobutylether-β-Cyclodextrin.

Despite the central role of cyclodextrins in supramolecular chemistry and biomedical formulations, their internal hydration dynamics have remained inaccessible to ultrafast vibrational spectroscopy due to the absence of a suitable vibrational reporter. Here, we present the first application of two-dimensional infrared (2DIR) spectroscopy to probe water dynamics inside a cyclodextrin cavity under thermal equilibrium. By employing azidoadamantane (AdN)─an intelligently designed vibrational reporter that combines strong binding affinity for a cyclodextrin cavity with a spectrally isolated azide stretch─we investigate the host-guest complex of AdN and sulfobutylether-β-cyclodextrin (SBE-β-CD).

Wearable Technology in Cardiology: Advancements, Applications, and Future Prospects.

As the use of wearable devices continues to expand, their integration into various aspects of healthcare becomes increasingly prevalent. Indeed, significant advancements have been made in the field of cardiology through the application of wearable technology to monitor heart rate, rhythm, and other biological signals. This review examines the various applications of wearable technology in cardiology, with the goal of improving patient care.

Effect of lidocaine ice button topical anesthesia on pain during maxillary buccal infiltration in 6-10-year children - A randomized control trial.

Context: Effective pain management in children during local anesthetic administration would be a key to a successful and painless dental procedure. Precooling (PC) has emerged as pain control tool in dentistry.

Aims: This study aims to evaluate and compare the efficacy of lidocaine Ice button and lidocaine gel as topical anesthesia during maxillary buccal infiltration in children.

Agonism of MT and MT Receptor Mitigates Oxidative Insult, Neuroinflammation, and Cerebral Injury in Cadmium Chloride Treated Animals.

Cadmium (Cd), the stronger neurodegenerating heavy metal, provokes oxidative insult and disturbances in the brain. This study has been structured to investigate the neuroprotective activity of agomelatine, a specific melatonin (MT and MT) receptor agonist, against cadmium chloride (CdCl)-induced toxic changes in Wistar rats. The study involved 36 animals that were arbitrarily separated into six groups i.

Spontaneous Colonic Diaphragmatic Pericardial Herniation Causing Colonic Obstruction and Right Ventricular Collapse.

A 76-year-old man presented with diaphragmatic herniation of the colon that was causing bowel obstruction with gangrene seen on a computed tomography scan and right ventricular (RV) collapse seen on a transthoracic echocardiogram. The patient's condition was successfully managed with emergency robotic colectomy and diaphragmatic hernia repair. His RV function returned to normal, and he had no sign of diaphragmatic herniation recurrence at follow-up or on imaging.

Cerebroprotective Potential of Androgen Receptors in Ischemic Postconditioning against Cerebral Ischemia/Reperfusion-Induced Neurodegenerative Changes.

Background And Objective: In stroke, reperfusion of blood to the cerebral ischemic area following sustained ischemia further exacerbates tissue damage, identified as cerebral ischemia and reperfusion (I/R) insult. Ischemic post-conditioning (IPoC) appears to offer benefits against I/R injury. The cascade of androgen receptors (ARs) has a vital role in cerebral stroke; however, its neurodefensive function in IPoC is unclear.

A Comprehensive Review of Candidemia and Invasive Candidiasis in Adults: Focus on the Emerging Multidrug-Resistant Fungus .

Candidemia and invasive candidiasis represent critical healthcare-associated fungal infections that pose substantial challenges to medical systems worldwide. These conditions arise when fungi from the Candida genus infiltrate the bloodstream or deeper tissues, leading to a range of clinical manifestations. Among the various species, continues to hold its position as the most frequently encountered causative agent, largely due to its prevalence and adaptability within human hosts.

Outcomes of Acute Kidney Injury Among Hospitalized Patients with Sepsis and Acute Myeloid Leukemia: A National Inpatient Sample Analysis.

Sepsis in patients with acute myeloid leukemia (AML) is one of the causes of acute kidney injury (AKI). There are no available data on the outcomes of AML-related AKI patients. We researched the 2016-2020 National Inpatient Sample (NIS) database to collect data on hospitalizations of patients ≥18 years old with sepsis and AML.

YOPRO-1: A Cyanine-Based Molecular Rotor Probe for Amyloid Fibril Detection.

The widespread occurrence of amyloidosis in many neurodegenerative diseases, including Alzheimer's, highlights the urgent need for early detection methods. Traditional approaches often fall short in sensitivity, specificity, and the ability to operate within complex biological matrices. Fluorescence spectroscopy, which leverages the unique properties of extrinsic fluorescence sensors, has emerged as a promising avenue for amyloid detection.

Candidate transmission survival genome of .

(Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we mimicked liquid and atmospheric conditions experienced by Mtb before and after exhalation using a model aerosol fluid (MAF) based on the water-soluble, lipidic, and cellular constituents of necrotic tuberculosis lesions. MAF induced drug tolerance in Mtb, remodeled its transcriptome, and protected Mtb from dying in microdroplets desiccating in air.

Agromorphological and biochemical characterization of mutagens induced M3 mutant lines of grasspea.

Grasspea is one of the important cool season legumes in India and it is hardy in nature. Although this crop is robust, it is not commonly grown because presence of more amount of the β-N-oxalyl-L-α, β diaminopropionic acid (β-ODAP) in the seeds and it causes neurolathyrism. Due to low levels of genetic variation in β-ODAP content in grasspea made it difficult to improve through traditional breeding.

Artificial Intelligence in Nephrology: Clinical Applications and Challenges.

Artificial intelligence (AI) is increasingly used in many medical specialties. However, nephrology has lagged in adopting and incorporating machine learning techniques. Nephrology is well positioned to capitalize on the benefits of AI.

A Rare Case of Vancomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially life-threatening adverse drug reaction characterized by extensive skin rash in association with hematological abnormalities, including eosinophilia and atypical lymphocytosis, lymphadenopathy, fever, and extensive visceral organ involvement. Here, we presented a rare case of vancomycin-induced DRESS syndrome in a male who was treated with IV vancomycin for a brain abscess.

Cardiac Implantable Electronic Device Infections in Patients with Renal Insufficiency: A Systematic Review and Meta-Analysis.

Renal insufficiency is a risk factor for cardiac implantable electronic device (CIED) infection. : A comprehensive search was conducted from multiple electronic databases to identify studies. Using the random effects model, we calculated the pooled rates of CIED infection and their 95% confidence intervals.

Advanced AIE Materials for Environmental Monitoring: Selective Sensing of Thorium(IV) in Aquatic Systems.

Thorium (Th) is commonly used in various applications, but its long-term exposure poses health risks, necessitating its detection in aqueous environments. Traditional methods such as inductively coupled plasma mass spectrometry are sensitive but require complex instrumentation. Optical sensors, particularly fluorometry-based methods, are simpler, cost-effective, and selective.

Electrostatically Engineered Tetraphenylethylene-Based Fluorescence Sensor for Protamine and Trypsin: Leveraging Aggregation-Induced Emission for Enhanced Sensitivity and Selectivity.

The accurate detection of Protamine and Trypsin, two biomolecules with significant clinical and biological relevance, presents a substantial challenge because of their structural peculiarities, low abundance in physiological fluids, and potential interference from other substances. Protamine, a cationic protein, is crucial for counteracting heparin overdoses, whereas Trypsin, a serine protease, is integral to protein digestion and enzyme activation. This study introduces a novel fluorescence sensor based on a (4-(1,2,2-tris(4-phosphonophenyl)vinyl)phenyl)phosphonic acid octasodium salt (TPPE), leveraging aggregation-induced emission (AIE) characteristics and electrostatic interactions to achieve selective and sensitive detection of these biomolecules.

A case of COVID-19-associated C-ANCA vasculitis, was successfully treated with rituximab therapy.

Both C-anti-neutrophil cytoplasmic antibody (ANCA) and P-ANCA vasculitis were reported to be associated with COVID-19 infection. The ideal management of COVID-19-associated ANCA vasculitis is unclear, as the experiences were limited to case reports. We presented a case of COVID-19-associated C-ANCA vasculitis, successfully treated with steroids and rituximab therapy without any significant adverse reactions.

Outcomes of Acute Kidney Injury among Hospitalized Patients with Infective Endocarditis: A National Inpatient Sample Analysis.

: Patients with infective endocarditis (IE) are more susceptible to acute kidney injury (AKI). The presence of AKI increases in-hospital complications in these patients. : The 2016-2020 National Inpatient Sample (NIS) database consisting of adult admissions with IE and AKI was utilized.

Multi-Facet analysis of analytical and numerical models to resolve sustainable artificial recharge rates in unconfined aquifers.

Managed aquifer recharge (MAR) has emerged as a potential solution to resolve water insecurity, globally. However, integrated studies quantifying the surplus source water, suitable recharge sites and safe recharge capacity is limited. In this study, a novel methodology is presented to quantify transient injection rates in unconfined aquifers and generate MAR suitability maps based on estimated surplus water and permissible aquifer recharge capacity (PARC).

A decision support system for localized planning of reclaimed water around wastewater treatment plants.

Exploding population, industrialization, and an increase in water pollution has led to acute shrinkage in freshwater availability. Numerous countries have started exploring municipal wastewater as a new potential source of water to bring a paradigm shift from linearity to obtaining circularity in human water cycle management. This study aims to develop a decision support system for integrated water and wastewater management (DSS_IWWM), targeted towards reuse-focused selection of appropriate wastewater treatment technology, and localized planning around STPs in terms of reclaimed water demand identification, estimation, allocation, and sustainable pricing.

Ecological impact of pharmaceutical pollutants and options of river health improvements - A risk analysis-based approach.

Pharmaceuticals are one of the emerging pollutants (EPs) in river waters across the world. Due to their toxic effects on aquatic organisms, they have drawn the global attention of the scientific community concerned with river ecosystems. This paper reviews the existing occurrence data for various pharmaceutical pollutants (PPs) reported in river waters in some part of the world and their ecological impacts.