Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging.

Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified deleterious mutations and decreased expression of NCOA7, a stress-response protein related to granulosa cell senescence in women with physiological and pathological ovarian aging. NCOA7 deletion accelerates oxidative stress-related cellular senescence, ovarian aging and fecundity decline in mice.

CCR8 decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy.

Regulatory T (T) cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. T cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4 T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8 T cell subset specifically enriched in the decidua (dT cells).

Two distinct resident macrophage populations coexist in the ovary.

Introduction: Tissue-resident macrophages (TRMs) are highly heterogeneous and have a complex and important role in tissue support, homeostasis, and function. The heterogeneity, maintenance, and function of TRMs, as one of the major immune cells in the ovary, are not well understood.

Methods: Application of flow cytometry, Parabiosis, Fate mapping, Macrophage depletion, etc.

Aerodynamic Analysis and Training Research of an S-Shaped Arc Ball Based on Hydrodynamics.

The aerodynamic characteristics of S-shaped arc ball, such as poor combat performance and low intelligence, are studied and analyzed. In this paper, the aerodynamic analysis model of S-shaped arc soccer intelligent algorithm is established, and the dynamic tracking model of Soccer Tactics Based on fluid dynamics search algorithm is designed. The data information is collected from many aspects, such as the position of the players, the change of the arc ball movement, the trajectory of the football movement, and tactical flexibility.

The Impact of Moderately High Preconception Thyrotropin Levels on Ovarian Reserve Among Euthyroid Infertile Women Undergoing Assisted Reproductive Technology.

Thyroid dysfunction is prevalent in reproductive-age women and has been identified as a risk factor for female infertility. However, it remains largely unclear whether subtle thyroid dysfunction, as estimated by moderately high thyrotropin (TSH) levels within the normal range, is associated with ovarian reserve in infertile women before assisted reproductive technology (ART) treatment. This cross-sectional study involved 3501 euthyroid infertile women, including 2189 women with TSH levels ≤2.