Publications by authors named "Peter Matrai"
Infertility rates are indeed increasing globally, which emphasizes a pressing need to identify novel biomarkers exhibiting superior potential for laboratory diagnosis and personalized clinical management. This study aimed to explore the biological role of Galectin-9 (Gal-9) in female fertility and evaluate its diagnostic potential in the In Vitro Fertilization (IVF) program. A prospective cohort study was performed on 83 follicular fluids (FF) and 19 serum-FF pairs from IVF patients, 16 serum samples from fertile women, and 12 tissue sections.
View Article and Find Full Text PDFBackground: Spontaneous mentalizing refers to the capacity to attribute mental states to oneself and others without explicit prompts or conscious deliberation. This process enables individuals to comprehend and anticipate social behaviors in a more intuitive manner. Individuals diagnosed with schizophrenia frequently demonstrate deficits in this domain, which contribute to impaired social functioning.
View Article and Find Full Text PDFBackground: Current therapeutic guidelines for immune-mediated inflammatory diseases (IMIDs) contraindicate the administration of tumour necrosis factor inhibitors (TNFis) in advanced heart failure (HF) and highlight the potential risk for new-onset HF. The current evidence has low certainty, and the results of studies in the past two decades have even challenged the recommendations regarding the impact of TNFis on the risk of HF.
Objectives: The objective was to systematically synthesize data on the risk of HF in TNFi-treated groups compared to non-treated controls in IMIDs.
Background: Pancreatic cancer (PC) is a leading cause of cancer mortality, often diagnosed at advanced stages. Acute pancreatitis (AP), particularly idiopathic cases, may serve as an early indicator of PC.
Objective: This multicenter cohort study investigated the incidence of PC before and after an AP episode, focusing on idiopathic AP and the role of pseudocysts as potential early markers for PC development.
Background: Combining antegrade stenting (AGS) and hepaticogastrostomy (HGS) is an increasingly used endoscopic ultrasound-guided intervention when stenting by endoscopic retrograde cholangiopancreatography is impossible.
Objectives: We comprehensively assessed the benefits and downsides of combined AGS and HGS (HGS procedure with AGS, HGAS).
Data Sources And Methods: From 788 HGS and 295 HGAS cases, a random-effects meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.
Article Synopsis
- Aldosterone-producing adenomas lead to hypertension in 5-10% of cases, and this study compares laparoscopic adrenalectomy (the standard treatment) with ablative techniques for treating benign adrenal tumors.
- The review included five studies with a total of 280 patients, showing that both methods had similar complication rates, but laparoscopic adrenalectomy had a higher success rate in resolving hypertension.
- Although ablation had benefits like shorter procedure times and less blood loss, laparoscopic adrenalectomy is still considered the better treatment option overall.
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is essential for the minimally invasive management of biliary and pancreatic disorders. Under certain indications, performing ERCP without delay during the weekend can be important for improving outcomes.
Objectives: To compare the outcomes of ERCP performed on weekends and holidays with those of regular weekday ERCPs.
Article Synopsis
- - Snus is becoming more popular among youth, largely due to tobacco industry promotion and a lack of awareness about its harmful effects, particularly on oral health.
- - A study on adolescent athletes found that regular snus users experience higher rates of gum bleeding (60%) compared to nonusers (37%), and poor oral hygiene compounds these issues.
- - The research highlights the need for early education to increase awareness of snus's dangers, as nonusers showed greater knowledge about its adverse effects (49% vs. 27% among regular users).
Association between human papillomavirus and preterm delivery: A systematic review and meta-analysis.
Acta Obstet Gynecol Scand
October 2024
Article Synopsis
- HPV is a very common sexually transmitted infection, with about 80% of people likely to be infected during their lifetime, and this study investigates its potential link to bad pregnancy outcomes, focusing on genetically confirmed cases rather than just Pap smear results.
- The meta-analysis assessed data from 14 studies involving over 7,000 pregnant women, revealing a significant association between HPV infection and preterm delivery, although high-risk strains and specific types 16 and 18 didn't show a strong correlation with this outcome.
- The researchers stress the need for better consideration of other influencing factors in future studies and highlight the importance of HPV vaccination programs to potentially reduce these risks.
Article Synopsis
- The study investigated whether combining medial collateral ligament reconstruction (MCLR) with anterior cruciate ligament reconstruction (ACLR) enhances knee functionality compared to just ACLR in cases of combined ACL and MCL tears.
- After reviewing 2362 papers, only 8 studies were suitable for analysis, focusing on post-operative outcomes like IKDC score and Lysholm scale.
- The results showed no significant differences in knee functionality between the two treatments, indicating that adding MCLR might not provide added benefits, highlighting the need for more high-quality research in this area.
Article Synopsis
- Urachal cancer (UrC) is a rare bladder tumor, comprising less than 1% of all cases, with a poor 5-year survival rate of about 50% for resectable tumors and even lower for metastatic cases.
- A systematic review of registry-based studies identified 6 key publications, with overall incidence rates of UrC calculated at 0.04 per 100,000 person-years and highlighting geographic variations, notably higher in Japan.
- The study found that the median age at diagnosis is 60 years, with a female to male ratio of 2:3, and adenocarcinoma being the most common tumor type, making it vital to improve understanding and awareness of this rare cancer.
Domain-specific cognitive impairment in multiple sclerosis: A systematic review and meta-analysis.
Ann Clin Transl Neurol
March 2024
Objective: Methods of cognitive measurements in multiple sclerosis (MS) are not standardized. We aimed to identify the prevalence of cognitive domain-specific impairment (DSI) in MS by using subtests of the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) with analyzing different cutoff values.
Methods: The systematic review and meta-analysis were registered on PROSPERO (ID: CRD42021287004).
Article Synopsis
- * Findings show that older adults with sarcopenic obesity have a 15% lower risk of mortality compared to their non-obese counterparts, suggesting that SO may be a more favorable health state in this age group.
- * While SO adults faced lower physical performance and a higher risk for metabolic syndrome, they exhibited similar cognitive function and cardiovascular risks compared to SNO adults, indicating complex interactions between obesity, aging, and health outcomes.
Article Synopsis
- The study explored the effects of using long versus short abutments on bone-level implants, focusing on biological outcomes like marginal bone loss, bleeding, and probing depth.
- Conducted through a systematic review of randomized controlled trials up to January 2023, the analysis included eight qualifying studies from a search of over 4000 records.
- Results showed that while long abutments reduced early marginal bone loss, there were no significant differences in bone loss or bleeding when following the 'one abutment at one time' protocol.
Article Synopsis
- The study investigates the benefits of early oral feeding (EOF) versus late oral feeding after upper gastrointestinal surgeries for stomach and oesophageal cancer, focusing on recovery outcomes.
- Researchers reviewed 6 randomized control trials (RCTs) with 703 patients and found EOF led to faster recovery indicators like the appearance of gas and defecation, as well as shorter hospital stays.
- No significant difference in serious complications such as anastomosis leakage or infections was found between EOF and late feeding, suggesting EOF is safe and beneficial for patient recovery.
Fluid therapy is the cornerstone of early supportive therapy in acute pancreatitis (AP). Regrettably, the type of fluid is still debated among clinicians, despite recent evidence from randomized controlled trials (RCTs). We aimed to incorporate all evidence from RCTs comparing lactated Ringer's solution (LR) with normal saline (NS) in adult and pediatric AP patients, with particular emphasis on clinically relevant outcomes.
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- The study aimed to evaluate the immediate impact of physical vascular therapy (PVT) on the autonomic nervous system using heart rate variability (HRV) and heart rate asymmetry (HRA) analysis in patients with coronary heart disease.
- A total of 48 patients participated, with half receiving actual PVT and the other half undergoing sham treatment, while their heart activity was monitored before, during, and after the therapy.
- Results showed that PVT notably improved certain HRV indices, indicating a positive autonomic response, whereas the sham treatment did not yield significant changes, highlighting the sensitivity of HRA in measuring these effects.
Article Synopsis
- Noninvasive ventilation (NIV) shows promise in reducing mortality and intubation rates in adults with pneumonia-associated respiratory failure compared to not using NIV, although overall hospital mortality differences were not statistically significant.
- In intensive care settings, NIV significantly lowered mortality rates, demonstrating its effectiveness, especially among patients with overlapping conditions like COPD.
- The results suggest that NIV should be considered in treatment guidelines for pneumonia-related respiratory failure due to its substantial benefits in critical care outcomes.
Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.
Paediatr Perinat Epidemiol
March 2022
Article Synopsis
- Maternal overnutrition during pregnancy is linked to higher blood pressure (BP) in offspring, with a positive correlation found between maternal prepregnancy body mass index (ppBMI) and both systolic and diastolic BP in children.
- In the analysis of data from 17 studies with over 140,000 mother-offspring pairs, every 5 kg/m² increase in maternal ppBMI was associated with an increase of 1.9 mmHg in systolic and 0.5 mmHg in diastolic BP of offspring.
- While gestational weight gain (GWG) initially showed a relationship with offspring systolic BP, the correlation diminished when adjusting for the child's BMI,
Article Synopsis
- Multiple tissues in the gastrointestinal tract, including periodontal structures, are essential for food delivery, but they are difficult to regenerate once damaged, leading to reliance on traditional treatments for periodontal disease like scaling and root planning.
- Probiotics have been suggested as a new way to improve oral health by potentially reducing harmful bacteria through their anti-inflammatory properties, although research results on their effectiveness have been mixed.
- A meta-analysis was conducted analyzing nine studies, which showed that probiotics significantly decreased certain bacterial counts after 4 weeks, but did not have a lasting impact or a significant effect on overall bacterial counts in higher-risk areas of the mouth.
Article Synopsis
- * Results showed significant improvement in symptom control, with a notable reduction in negative symptoms (mean change of -6.3), and over 70% of patients showed at least minimal improvement by the end of the study.
- * While 40% of patients reported adverse events, more than 70% of doctors found cariprazine effective and tolerable for treating their patients' schizophrenia.
Article Synopsis
- Chronic pancreatitis (CP) is a severe condition with no specific treatment, making early diagnosis essential for better outcomes.
- A study analyzed data from both acute pancreatitis (AP) and chronic pancreatitis (CP) patients, revealing that experiencing three or more episodes of AP significantly increases the risk of developing CP.
- Findings suggest that patients with three or more recurrent AP episodes could be classified as having early chronic pancreatitis (ECP), allowing for earlier diagnosis without extra healthcare costs.
Article Synopsis
- Adequate anticoagulation during catheter ablation for atrial fibrillation is essential to prevent serious bleeding and clot-related events.
- This updated meta-analysis evaluated the safety and effectiveness of uninterrupted and minimally interrupted direct oral anticoagulants (DOACs) compared to uninterrupted vitamin K antagonists (VKAs) in patients undergoing the procedure, based on 42 studies involving over 22,000 patients.
- The results indicated that patients on uninterrupted DOAC therapy experienced significantly lower major bleeding rates than those on VKAs, while both DOAC strategies proved effective in preventing strokes and transient ischemic attacks, making them preferable options for anticoagulation during the procedure.