Publications by authors named "Istvan Ruzsics"
Introduction And Objectives: Medical costs of patients with chronic obstructive pulmonary disease (COPD) are high, however data from Eastern European countries are scarce. We aimed to study healthcare payments for patients with COPD on maintenance inhaled therapy in Hungary and analyse the trends and influencing factors between 2011 and 2019 in a retrospective financial database analysis.
Patients: We collected data of patients from the Hungarian National Insurance Fund, who were > 40 years old, received maintenance inhaled therapy > 90 days within 12 months prescribed for J41-44 International Classification of Diseases-10 codes.
Article Synopsis
- Noninvasive ventilation (NIV) shows promise in reducing mortality and intubation rates in adults with pneumonia-associated respiratory failure compared to not using NIV, although overall hospital mortality differences were not statistically significant.
- In intensive care settings, NIV significantly lowered mortality rates, demonstrating its effectiveness, especially among patients with overlapping conditions like COPD.
- The results suggest that NIV should be considered in treatment guidelines for pneumonia-related respiratory failure due to its substantial benefits in critical care outcomes.
Double Stenting for Malignant Biliary and Duodenal Obstruction: A Systematic Review and Meta-Analysis.
Clin Transl Gastroenterol
April 2020
Article Synopsis
- A systematic literature review was conducted to evaluate the effectiveness and best methods for palliative double stenting in cases of malignant duodenobiliary obstruction, comparing this technique with surgical double bypass.
- The review included 80 studies, revealing high technical (97%) and clinical success rates (92%) for double stenting, as well as showing that endoscopic biliary stenting had a higher clinical success than surgery (97% vs 86%).
- Despite having fewer adverse events (13% vs 28%), double stenting required more reinterventions (21% vs 10%) compared to surgical options, with ERCP being the best option for minimizing adverse events.
Role of microparticles derived from monocytes, endothelial cells and platelets in the exacerbation of COPD.
Int J Chron Obstruct Pulmon Dis
April 2019
Background: Microparticles (MPs) are shedding membrane vesicles released from activated blood and endothelial cells under inflammatory conditions. The role of endothelial MPs (EMPs) in pathophysiology of COPD is relatively well known. However, the release and function of MPs of other cellular origins, eg, platelets, red blood cells and leukocytes, are not clearly evaluated in COPD.
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) is a devastating, irreversible pathology affecting millions of people worldwide. Clinical studies show that currently available therapies are insufficient, have no or little effect on elevated comorbidities and on systemic inflammation. To develop alternative therapeutic options, a better understanding of the molecular background of COPD is essential.
View Article and Find Full Text PDFIn the last decades new therapeutic drugs have been developed for the treatment of non-small cell lung cancer (NSCLC) patients. Tyrosine kinase inhibitors (TKIs) significantly increase the progression free survival (PFS) of patients with NSCLC carrying epidermal growth factor receptor (EGFR) mutations. This type of lung cancer occurs mainly among non-smoking women and Asian origin.
View Article and Find Full Text PDFBackground: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment.
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