Knowledge and attitudes about rare genetic diseases among practitioners of oral medicine/pathology in Brazil: a cross-sectional study.

Introduction: This study aimed to analyze the knowledge and attitudes of Brazilian Oral Medicine and Pathology (OM/OP) specialists about genetic diseases.

Methods: A cross-sectional and descriptive study was conducted with Brazilian OM/OP specialists, using a pre-structured online formulary. Statistical analyses were performed using Statistical Package for the Social Sciences (SPSS®).

Vegetative pyodermatitis-pyostomatitis in a patient with Crohn's disease: a clinical case report.

Introduction: Pyodermatitis-pyostomatitis vegetans (PPV) is a rare inflammatory mucocutaneous dermatosis of unknown etiology. It is characterized by the appearance of vesicles, pustules, vegetating plaques, and erythematous lesions, often associated with underlying inflammatory bowel diseases such as Crohn's disease.

Objective: To report a case of vegetative pyostomatitis in a patient with Crohn's disease, focusing on the diagnostic process and therapeutic approach.

Imaging features of a brown tumor with extensive skull involvement: Relevance for dental radiology.

This case report describes a rare, asymptomatic brown tumor in a patient with end-stage renal disease. The lesion was incidentally detected during a computed tomography (CT) scan of the paranasal sinuses, performed upon a dentist's recommendation to investigate maxillary sinusitis. CT imaging revealed an expansive osteolytic lesion with irregular margins and a ground-glass appearance involving the left side of the sphenoid and frontal sinuses.

Bidirectional interaction between epithelial-mesenchymal transition and PD-1/PD-L1 expression in tongue carcinogenesis.

Objective: To investigate, through immunohistochemistry, the interaction between epithelial-mesenchymal transition (EMT) and the immune checkpoint proteins PD-1 and PD-L1 in oral tongue squamous cell carcinoma (OTSCC).

Design: The EMT status was determined based on the immunostaining of E-cadherin and N-cadherin proteins. EMT status and the immunoexpression of PD-L1 and PD-1 were analyzed semiquantitatively in 61 cases of OTSCC, and the cases were categorized into low and high expression groups for association with clinicopathological variables and overall survival (OS) and disease-free survival (DFS) rates.

Telehealth in oral medicine: Evaluation of app usability and satisfaction among public health system professionals.

ObjectiveEvaluate the usability and user satisfaction of an oral medicine application among public health professionals.MethodsA cross-sectional observational study was conducted with 101 dentists registered in the application, determined through sample size calculation. Data were collected using an online questionnaire.

Mucinous adenocarcinoma of the base of the tongue: A case report.

A 50-year-old male patient presented with a nodular lesion at the right base of the tongue. An incisional biopsy was performed, and the histopathological evaluation revealed an ill-defined multicystic papillary proliferation of mucin-producing cells. Immunohistochemically, tumor cells were positive for CK7 and negative for CK20, p40, p63, SOX10, SMA, and calponin.

Performance of a virtual assistant based on ChatGPT-4 in the diagnosis of syndromes with orofacial manifestations.

Objective: To evaluate the performance of the virtual assistant "Syndromic Diseases and Orofacial Features" (SDOF), developed based on the Generative Pre-trained Transformer 4 model, in formulating diagnostic hypotheses and recommendations for syndromes with orofacial manifestations.

Study Design: Twenty-six anonymized, previously diagnosed clinical cases, including clinical features and images, were selected. The assistant was trained using scientific references and configured to generate diagnostic hypotheses and suggest complementary exams.

Ion release, cytocompatibility and microbial inhibition of a novel varnish containing fluoride-doped bioactive glass ceramics: an in vitro study.

Objectives: The study aimed to develop and evaluate in vitro a varnish containing fluoride-doped glass ceramics capable of inhibiting oral microorganisms, releasing hydroxyapatite-forming ions, and ensuring biocompatibility.

Materials And Methods: For the production of the experimental varnish (VE), composed of hydrogenated rosin, 10% and 20% by weight of glass ceramics with composition S53P4 (CF0) and doped with F- ions (CF5 and CF10) were incorporated. The EVs were characterized by Rheology, Scanning Electron Microscopy (SEM), FTIR, ion release (fluoride and calcium ions), cytotoxicity on VERO cells, and antimicrobial effect on S.

Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient.

Small cell osteosarcoma (SCOS) is a rare variant of conventional osteosarcoma, characterized by tumor cells of small size and uniform morphology, which can lead to diagnostic confusion with other small cell tumors, requiring a detailed diagnostic approach. The manifestation in a child adds a degree of complexity, as the management of malignant tumours in paediatric patients requires specific considerations to minimize the long-term side effects of oncological treatment and preserve the structural and functional development of the orofacial region. This report concerns an 8-year-old female patient referred to the Oral and Maxillofacial Surgery outpatient clinic with progressive swelling in the right maxillofacial region, initially asymptomatic, but progressing to pain and difficulty chewing.

TeleCleft: Development and Evaluation of a Mobile Application for Monitoring Cleft Patients.

ObjectiveDevelopment and evaluation of a mobile application for remote monitoring and guidance of pediatric patients diagnosed with cleft lip and/or palate (CL ± P) and their caregivers.DesignThis is a pilot cross-sectional, applied, and quantitative study.SettingThe study was conducted in two tertiary care treatment centers in Brazil.

Digital resources in the monitoring of patients with cleft lip and palate: protocol for a scoping review.

Introduction: Cleft lip and/or palate (CL+/-P) is a congenital malformation affecting the lip and palate, requiring long-term treatment due to potential associated complications. For this reason, it is important for the patient to be continuously monitored and followed for health promotion and prevention, as well as improving the quality of life. The aim of this scoping review protocol is to identify and map the available evidence regarding the application of digital resources and technologies in the monitoring and follow-up of patients with CL+/-P.

Telehealth in oral medicine: A cross-sectional evaluation based on a mobile application.

Background: Teledentistry is considered a good tool in the diagnostic process. In oral medicine, there is a low number of trained professionals and dentists have difficulty in diagnosing and treating oral lesions.

Objective: We aimed to perform a cross-sectional evaluation based on the mobile application for oral diagnosis using a mobile application in a Brazilian State.

Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis .

Objective: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats.

Methods: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8, G3).

Antimicrobial effect and the mechanical and surface properties of a self-disinfecting and a chlorhexidine-incorporated Type IV dental stone.

Statement Of Problem: Stone casts are subject to contamination, but whether disinfectants incorporated into the stone are effective is unclear.

Purpose: The purpose of this in vitro study was to evaluate the antimicrobial activity and the mechanical and surface properties of self-disinfecting gypsum (SDG) and gypsum mixed with 2% chlorhexidine (GCHX).

Material And Methods: Antimicrobial action was evaluated using the diffusion-disk technique on Streptococcus aureus and Candida albicans 1 hour and 24 hours after pouring the gypsum.

Implications and Emerging Therapeutic Avenues of Inflammatory Response in HPV+ Head and Neck Squamous Cell Carcinoma.

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignancies which have shown exponential incidence in the last two decades especially due to human papillomavirus (HPV) infection. The HPV family comprises more than 100 types of viruses with HPV16 and HPV18 being the most prevalent strains in HNSCC. Literature data reveal that the mutation profile as well as the response to chemotherapy and radiotherapy are distinct among HPV+ versus HPV-negative tumors.

Impact of COVID-19 on dental practice and anxiety among increased risk group dentists: A cross-sectional study.

Background: The likelihood of infection with SARS-COV-2 (COVID-19) in the dental office is considered high.

Objectives: Assessing the impact of the COVID-19 on dental practices and anxiety levels in risk group Brazilian dentists.

Methods: A cross-sectional study was performed using an online questionnaire.

Evaluation of the economic impact of COVID-19 on Brazilian private dental clinics: A cross-sectional study.

Background: The changes in dental care in the face of the COVID-19 pandemic resulted in the need for greater financial investment by dentists in biosafety measures and increase in the costs of dental consultations.

Objective: To evaluate the economic impact of the COVID-19 pandemic on dental practices in private clinics in Brazil.

Methods: A cross-sectional study was carried out, using an online questionnaire indexed in Google Forms, and distributed among dentists.