Publications by authors named "Patricia Quintana-Espinoza"
Bioorg Med Chem
March 2017
Article Synopsis
- A group of 5-ethynylarylnaphthalimides was created using Sonogashira cross-coupling reactions and tested for their ability to fight cancer and inhibit topoisomerase II in lab trials.
- Three specific naphthalimides (compounds 6, 13, and 14) showed particularly strong activity against topoisomerase II, which is important for DNA processes in cells.
- Additionally, compounds 13 and 14 demonstrated high toxicity in live organisms (using yeast) and showed promise as effective DNA-intercalators, suggesting their potential as cancer treatment agents.
Bioorg Med Chem
November 2013
Article Synopsis
- A new series of arylnaphthalimides were created to reduce the harmful effects of N-acetylated metabolites from amonafide, a cancer-fighting drug known for intercalating DNA and inhibiting Topoisomerase II.
- The new compounds were tested for their effectiveness against two tumor cell lines, their ability to inhibit Topoisomerase II, and their interaction with DNA using both laboratory assays and modeling techniques.
- Results indicated that the newly developed 5-arylsubstituted naphthalimides not only maintained the beneficial properties of amonafide but also enhanced its biological activities.
