Phenotypes and Genotypes of Children with Vitamin D-Dependent Rickets Type 1A: A Single Tertiary Pediatric Center in Vietnam.

: Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by mutations in the gene, leading to a deficiency in active vitamin D (1,25-dihydroxyvitamin D). This study examines the genotypic and phenotypic characteristics of VDDR1A in Vietnamese children. : A retrospective analysis was conducted on 19 Vietnamese children diagnosed with VDDR1A.

The lipidome landscape of amiodarone toxicity: An in vivo lipid-centric multi-omics study.

Amiodarone is an effective therapy for arrhythmias, its prolonged management may lead to significant adverse drug reactions. Amiodarone-induced hepatotoxicity is described by phospholipidosis, hepatic steatosis, cholestatic hepatitis, and cirrhosis. However, the systemic and hepatic lipidome disturbances and underlying toxicological mechanisms remain comprehensively elucidated.

Synthesis and biological evaluation of diastereomeric natural products: Discovery of a novel synergistic combination for α-glucosidase inhibition.

Cabraleahydroxylactone (1a) and 3-epi-cabraleahydroxylactone (1b) are naturally diastereomers found in Aglaia abbreviata, known for their biological potential. While 1b has been synthesized and studied as an anti-diabetic agent, the activity of 1a remained unexplored. This study successfully enhanced 1a in the reaction mixture through the reduction of cabralealactone (2), increasing its ratio from trace levels to 9.

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

A search is performed for dark matter particles produced in association with a resonantly produced pair of b-quarks with 30 View Article and Find Full Text PDF

Cardiovascular events, mortality, and incident type 2 diabetes in patients with metabolic dysfunction-associated steatohepatitis: a claims-based analysis of commercial and Medicare Advantage enrollees.

Background: The objective of this study was to examine the risks of cardiovascular events, incident type 2 diabetes (T2D), and mortality in patients with newly diagnosed metabolic dysfunction-associated steatohepatitis (MASH) compared with those without MASH in a large real-world setting in the US.

Methods: We retrospectively analyzed US claims data from Optum®'s de-identified Clinformatics® Data Mart database from October 2015 to December 2022. Patients with newly diagnosed MASH were matched 1:1 on age, sex, region, and index month-year with patients without MASH, and repeated for a subgroup without baseline diabetes.

Electron Perturbation for Chiral DNA Point Mutation.

Advances in molecular nanotechnology have enabled the design of systems that exploit nanoscale interactions for enhanced biosensing and diagnostics. Here, we present a plasmonic nematic film (PNF) that leverages nanoscale plasmonic hotspots to amplify electron perturbations induced by DNA mutations. Sequence-specific mismatches, particularly point mutations, significantly alter the local electromagnetic environment, leading to distinct and quantifiable spectral shifts in circular dichroism (CD), denoted as Δλ.

Seasonal Incidence of Medically Attended Respiratory Syncytial Virus Infection From 2015 to 2019 in a Cohort of Adults With High-risk Conditions.

Background: Adults with high-risk conditions (underlying health conditions that increase risk of severe outcomes after respiratory infection) may have a substantial incidence of respiratory syncytial virus (RSV), but existing information on this topic is limited. We assessed the seasonal incidence of RSV in adults with high-risk conditions in a Wisconsin community.

Methods: We conducted a retrospective study using data and respiratory specimens from participants with medically attended acute respiratory illness (MAARI) in a test-negative study of influenza vaccine effectiveness.

Metabolic disruptions induced by low concentrations of DMSO in RTgill-W1 fish cells: The importance of solvent controls in in vitro studies.

Dimethyl sulfoxide (DMSO) is a widely used solvent in biological research due to its ability to enhance membrane permeability, facilitating drug delivery and molecular transport across cellular membranes. However, its effects on cellular metabolism, especially at low concentrations, remain insufficiently understood. This study investigated the metabolic disruptions induced by 0.

Protein and polysaccharide edible coatings: A promising approach for fruits preservation - recent advances.

Biodegradable packaging, especially edible coatings (EC) for fruit preservation, is a sustainable and eco-friendly approach. ECs, such as polysaccharides and proteins, are widely used in fruit preservation, with a preference for polysaccharides in coating studies. Fundamental EC properties include barrier properties, tensile strength, elongation at break, and UV blocking.

Assessing iIndications for herbal medicinal products: a comparative analysis of EMA monographs and database records.

Background: Adverse effects are common during cancer treatment and herbal medicinal products (HMPs) are one way to manage symptoms caused by conventional therapy.

Objectives: This assessment focused on comparing HMP indications listed in European Medicines Agency (EMA) monographs with findings in Medline and the Cochrane Library. The objective of this study was to investigate whether there is evidence that HMP indications may be transferred from non-cancer patients to cancer patients for the treatment of therapy-induced symptoms.

Revisiting the Common Misconceptions About Traumatic Brain Injury Scale (CM-TBI); What Does It Really Measure?

Objective: To examine the factor structure and validity of the 40-item common misconceptions in traumatic brain injury (CM-TBI) scale, and to develop and evaluate additional concussion-focussed items to broaden the instrument's scope.

Method: A purposive sample of 988 participants from across all habitable continents (M age 43, range 16-90 years, 84% female) completed the CM-TBI and 5 additional concussion items at commencement of an online course on TBI.

Results: Item analysis resulted in the removal of 19 items due to ambiguous wording and poor conceptual integrity, and/or low discrimination and low inter-item correlations.

The oligosaccharyltransferase complex is an essential component of multiple myeloma plasma cells.

Multiple myeloma (MM) is an incurable malignancy characterized by mutated plasma cell clonal expansion in the bone marrow, leading to severe clinical symptoms. Thus, identifying new therapeutic targets for MM is crucial. We identified the oligosaccharyltransferase (OST) complex as a novel vulnerability in MM cells.

Innovating a Teach-Back Model for Community Health Workers Led Health Literacy Practice to Improve COVID-19 Health Equity.

Background: From 2021 to 2023, the City of Albuquerque, the University of New Mexico (UNM) Office for Community Health, the UNM Hospital Health Literacy Office (UNMH HLO), and partners in Albuquerque, New Mexico, implemented the Albuquerque COVID-19 Health Literacy Project (AHLP). The goal of the program was to develop a network of Community Health Workers (CHWs) and community agency partners able to use health literacy (HL) best practices to reduce coronavirus disease 2019 (COVID-19)-related health disparities in Albuquerque, New Mexico.

Brief Description Of Activity: AHLP created a training and support infrastructure to provide CHWs with the knowledge, skills and tools for using HL strategies and approaches for COVID-19 health promotion.

A Culturally Tailored Artificial Intelligence Chatbot (K-Bot) to Promote Human Papillomavirus Vaccination Among Korean Americans: Development and Usability Study.

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) worldwide and is associated with various cancers, including cervical and oropharyngeal cancers. Despite the availability of effective vaccines, significant disparities in HPV vaccination rates persist, particularly among racial and ethnic minorities, such as Korean Americans. Cultural stigma, language barriers, and limited access to tailored health information contribute to these disparities.

Comparative stabilization mechanism of self-assembling fattigated gelatin, micellar polyethylene glycol hexadecyl ether, and electrostatic interactive xanthan gum for aqueous labile decitabine.

Decitabine (DCB) is very unstable in aqueous solutions because of the opening of the N-5 and C-6 aza-ring. The objective of this study was to investigate a stabilization mechanism of aqueous-labile decitabine (DCB) with three different materials by preparing binary spray dried powders (SDs): self-assembling fattigated gelatin-oleic acid conjugate (GOC), micellar polyethylene glycol hexadecyl ether (Brij® 58), nonionic surfactant and electrostatically interactive xanthan gum (XA), an anionic polysaccharide. GOC was synthesized by covalently conjugating oleic acid with gelatin.

Small Bowel Complications After Sacrocolpopexy: A Case Series.

Importance: Ileus and small bowel obstructions are known but rare complications associated with minimally invasive sacrocolpopexy that can result in variable management.

Objectives: The objectives of this study were to describe the clinical presentation, management and outcomes of ileus or small bowel obstructions after minimally invasive sacrocolpopexy.

Study Design: This was a multicenter retrospective case series of postoperative ileus or small bowel obstruction after minimally invasive sacrocolpopexy.

Improved Metal-Semiconductor Interface in Monolayer (1L)-MoS via Thermally-Driven Ag Filaments as Atomic Scale Edge Contacts Triggered by Selective Annealing Process Using Long Wavelength (1064 nm) Pulsed Laser.

Here, we explore the effectiveness of a pulsed laser annealing (PLA) process to trigger atomic scale edge contacts by Ag filaments in reducing the contact resistance of a MoS field-effect transistor (FET). Employing a long wavelength (1064 nm) pulsed laser, we anneal monolayer (1L)-MoS FETs with various metal electrodes, including Ag/Au, Ni/Au, and Cr/Au. A remarkable enhancement in FET performance could be achieved after the PLA treatment.

Antibiotic dispensing without a prescription across community pharmacies: A simulated patient study.

Objectives: This study aimed to investigate the proportion of antibiotics dispensed, counseling content, and factors associated with antibiotic dispensing for patients with common cold symptoms among community pharmacists (CPs) in Ho Chi Minh City (HCMC).

Methods: A cross-sectional study was conducted from January to June 2023 using a simulated patient (SP) method. A total of 352 community pharmacies across 24 districts in HCMC were randomly selected.

Masked uncontrolled hypertension in patients with end-stage kidney disease on in-center hemodialysis.

Background: Masked uncontrolled hypertension (MUCH) is associated with an increasing risk of morbidity and mortality. Current literature on MUCH lacks data on patients with end-stage kidney disease (ESKD) on hemodialysis (HD). We aimed to investigate the prevalence, ambulatory blood pressure (BP) characteristics, and risk factors of MUCH in this population in a low-middle-income Asian country.

Electrostatic charge at the biomaterial-pathogen interface influences antibiotic efficacy.

Implant-associated infections (IAI) are a considerable burden for healthcare systems globally. While novel anti-infective biomaterials are being pursued, prophylactic antibiotic treatment remains the most important intervention for mitigating IAI. The antibiotic tolerance of bacteria has been widely studied, but until recently, the contributions of biomaterial-pathogen interactions have been overlooked.

Advancing UPLC-MS/MS for mapping the chemical fingerprint of bioactive compounds in lotus leaves (Folium Nelumbinis).

Lotus (Nelumbo nucifera Gaertn.) is widely utilized in traditional medicine and cuisine throughout Asia, with its leaves containing valuable bioactive alkaloids and flavonoids. However, Lotus leaves are often considered as by-products, urging the need for methods to analyze these components and enhance biological and economic value.

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.

In polyglutamine (polyQ) diseases, including Huntington disease (HD) and spinocerebellar ataxia type 3 (SCA3), targeting the mutant CAG tract in mRNA could be a therapeutic strategy for lowering pathogenic protein. We explored the viability of this therapeutic strategy at the level of the reagent design, toxicity, systemic delivery, brain regions transduction, silencing efficiency, and allele preference. We designed a series of CAG-directed short hairpin RNAs (shRNAs) based on a previous A2 reagent, allele selective .