Evaluating the potential of travoprost-thymoquinone co-loaded liposomes: a glaucomatous rabbit model study.

Aim: Glaucoma is associated with abnormal IOP elevation leading to irreversible blindness. In this study, we explore the therapeutic potential of thymoquinone in combination with travoprost to enhance the treatment efficacy of glaucoma.

Method: Thymoquinone-travoprost co-loaded liposomes (LP-TP-TQ) were formulated using thin-film hydration technique and optimized using BBD.

Invisible warriors: the invisible arsenal of nanotechnology against retinoblastoma.

Retinoblastoma, the most common kind of intraocular cancer in children, develops when there are mutations in the RB1 gene, which normally encourage the proliferation of retinal cells. Preserving vision and preventing metastases requires prompt diagnosis and suitable treatment. Standard treatments often have problems, like the chance of systemic harm, drug tolerance, and poor absorption in the eyes.

Translational Potential of Surface Engineered Extracellular Vesicles as Theranostic Nanocarriers in Cancer Management: Recent Developments from Bench to Bedside.

Extracellular vesicles (exosomes) are being continuously investigated by researchers as alternative diagnostic and targeted drug delivery nanocarriers for cancer theranostics. Exosomes are nano-extracellular vesicles that contain different biomolecules, including proteins, lipids, and nucleic acids. The natural intercellular communication tendency in recent discoveries to exhibit distinct characteristics in diseased states makes them more interesting for researchers.

Nanotechnology in Uveal Melanoma: Cutting-Edge Advances to Halt Progression and Metastasis.

Uveal melanoma (UM) represents the most prevalent primary intraocular malignancy in adults, distinguished by its aggressive progression and significant propensity for metastasis, predominantly to the liver and lungs. Despite advances in diagnostic tools and therapeutic approaches, the prognosis for metastatic UM remains dismal, underlining the critical need for novel treatment regimens. Nanotechnology is an exciting new area in the treatment of UM that offers creative ways to get around the problems with current medicines.

Nanotechnology-Driven Colorectal Cancer Treatment: Coencapsulation of Irinotecan and Cyclosporine A in SNEDDS for Superior Outcomes.

Irinotecan (IRN), a camptothecin derivative, has limited and inadequate oral absorption due to efflux pump activity by intestinal P-glycoprotein receptors. To complete these challenges, we designed and fabricated irinotecan and cyclosporine. A coloaded self-nanoemulsifying drug delivery system (CO-IR-CP-SNs) can effectively prevent P-gp efflux and P450 enzyme metabolization, increasing oral bioavailability.

Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights.

Extensive research over the years has revealed the remarkable potential of gold nanoparticles (AuNPs) for detecting biomarkers in osteoarthritis (OA). AuNPs are a promising class of nanomaterials offering a wide range of diagnostic and clinical applications. It provides an effective and robust framework for qualitative and quantitative analysis of biomarkers present in the biological fluids of OA patients.

Development and evaluation of nilotinib-loaded Bovine Serum Albumin nanoparticles: In-vitro and in-silico insights.

Breast cancer (BC) is one of the leading causes of death among females across the globe. However, there are limited formulations which meet the requirement for the dose amount delivered in the required window. The objective of this study was to synthesize a biomacromolecule based drug delivery system which not only ensures safety but also provide prolonged drug release profile.

Tyrosine Kinase Inhibitor Lenvatinib Based Nano Formulations and Cutting-Edge Scale-Up Technologies in revolutionizing Cancer Therapy.

Lenvatinib (LEN), a tyrosine kinase inhibitor, has emerged as a promising therapeutic agent for various solid tumors. Nevertheless, a number of constraints, including diminished bioavailability, incapacity to elicit localized inflammation, and inability to selectively accumulate at the tumor site, may impede the comprehensive exploitation of its versatile tyrosine kinase inhibitory capabilities. In order to achieve targeted delivery of LEN while also reducing its high dose used in conventional therapeutics, nanoformulation approaches can be adopted.

Nano-interventions for dengue: a comprehensive review of control, detection and treatment strategies.

Dengue, a formidable life-threatening malady, currently exerts a profound impact upon the Western Pacific and Southeast-Asian developing and underdeveloped nations. The intricacies inherent in addressing dengue are manifold, requiring a concerted effort not only towards vector control but also the implementation of efficacious host treatments to forestall the progression of the disease into severe manifestations, such as hemorrhage and shock. The only vaccine available for dengue in the market is DENGVAXIA, with several other vaccine candidates which are currently in the clinical developmental stages.

Supramolecular polymers: A perspective on the stability, biocompatibility and regulatory aspects.

Supramolecular polymers represent a distinctive class of polymers exhibiting similarities with covalent polymers, while also showcasing distinctive attributes such as responsiveness, reversibility, self-healing, and dynamism, which are conferred upon them by non-covalent interactions including hydrogen bonding, electrostatic interactions, van der Waals forces, π-π arrangements, and donor-acceptor interactions, among others. The noteworthy features of these supramolecular polymers have attracted considerable interest across diverse fields of science and technology, spanning electrochemistry, environmental science, drug delivery and tissue engineering. Nonetheless, the prevailing research focus in the realm of supramolecular polymers revolves around the advancement of novel methodologies aimed at synthesizing a broad spectrum of polymers characterized by diverse topologies.

Fabrication and characterization of teriflunomide-loaded chondroitin sulfate hybridized zein nanoparticles for the management of triple negative breast cancer.

The objective of this work was to explore the Teriflunomide (TFM) -loaded chondroitin sulfate hybridized zein nanoparticles (TZCNPs) for the treatment of triple-negative breast cancer (TNBC). The particle size, PDI and %EE of optimized TZCNPs was found 208.7 ± 7.

Exploration of the Topical Nanoemulgel Bearing with Ferulic Acid and Essential Oil for Diabetic Wound Healing.

To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of the novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)]. Ferulic acid nanoemulsion developed with lemongrass oil is investigated in diabetic wound healing. Further nanoemulsion is incorporated into 1% carbopol 934 to obtain the DLMGO-G.

Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound.

To treat diabetic wound healing with a novel Thymoquinone (TQ) loaded nanoformulation by using combination of essentials oils. TQ nanoemulsion (NE) was developed with seabuckthorn & lavender essential oils by phase inversion method and mixture design. Further, DIAGEL is obtained by incorporating NE into 1% carbopol934.

Modulation of chondroprotective hyaluronic acid and poloxamer gel with Ketoprofen loaded transethosomes: Quality by design-based optimization, characterization, and preclinical investigations in osteoarthritis.

Osteoarthritis (OA) is a chronic joint disease that results in biomechanical and morphological changes that contribute to cartilage degradation. Ketoprofen (KP), used in the treatment of OA, is a selective inhibitor of cyclooxygenase-2 (COX-2). Topical administration of KP bypasses gastric irritation as well as first-pass metabolism and increases localized delivery.

Ionic liquid-based formulation approaches for enhanced transmucosal drug delivery.

The utilization of ionic liquids (ILs) in pharmaceutical drug delivery applications has seen significant expansion in recent years, owing to their distinctive characteristics and inherent adjustability. These innovative compounds can be used to tackle challenges associated with traditional dosage forms, such as polymorphism, inadequate solubility, permeability, and efficacy in topical drug delivery systems. Here, we provide a brief classification of ILs, and their effectiveness in augmenting transmucosal drug delivery approaches by improving the solubility and permeability of active pharmaceutical ingredients (APIs) by temporary mucus modulation aiding the paracellular transport of APIs, prolonging drug retention, and, thus, aiding controlled drug release across various mucosal surfaces.

Unlocking nature's arsenal: Nanotechnology for targeted delivery of venom toxins in cancer therapy.

Aim: The aim of the present review is to shed light on the nanotechnological approaches adopted to overcome the shortcomings associated with the delivery of venom peptides which possess inherent anti-cancer properties.

Background: Venom peptides although have been reported to demonstrate anti-cancer effects, they suffer from several disadvantages such as in vivo instability, off-target adverse effects, limited drug loading and low bioavailability. This review presents a comprehensive compilation of different classes of nanocarriers while underscoring their advantages, disadvantages and potential to carry such peptide molecules for in vivo delivery.

Tailoring micellar nanocarriers for pemetrexed in breast cancer: design, fabrication and evaluation.

To investigate the pemetrexed encapsulated polymeric mixed micelles (PMMs) against breast cancer treatment. We meticulously optimized the formulation and conducted extensive characterizations, including photon correlation spectroscopy for micellization, advanced analytical techniques and cell line assessments. The PMM exhibited favorable characteristics, with a spherical morphology, hydrodynamic particle size of 19.

Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed micelles through design, development, in-silico modelling, In-Vitro testing, and Ex-Vivo characterization.

Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental process in cell death, are the B-cell lymphoma 2 (Bcl-2) family proteins, namely Bcl-2 and Bax. These proteins have garnered attention as highly promising targets for the treatment of breast cancer.

Emerging In Vitro and In Vivo Models: Hope for the Better Understanding of Cancer Progression and Treatment.

Various cancer models have been developed to aid the understanding of the underlying mechanisms of tumor development and evaluate the effectiveness of various anticancer drugs in preclinical studies. These models accurately reproduce the critical stages of tumor initiation and development to mimic the tumor microenvironment better. Using these models for target validation, tumor response evaluation, resistance modeling, and toxicity comprehension can significantly enhance the drug development process.

Revamping the corneal permeability and antiglaucoma therapeutic potential of brinzolamide using transniosomes: optimization, and preclinical evaluation.

This study aims to explore potential of transniosomes, a hybrid vesicular system, as ocular drug-delivery vehicle. Thin-film hydration technique was used to fabricate brinzolamide-loaded transniosomes (BRZ-TN) and optimized using Box-Behnken design, further exhaustively characterized for physicochemical evaluations, deformability, drug release, permeation and preclinical evaluations for antiglaucoma activity. The BRZ-TN showed ultradeformability (deformability index: 5.

Innovative Nanoparticulate Strategies in Colon Cancer Treatment: A Paradigm Shift.

As a major public health issue, colorectal cancer causes 9.4% of total cancer-related deaths and comprises 10% of new cancer diagnoses worldwide. In the year 2023, an estimated 153,020 people are expected to receive an identification of colorectal cancer (CRC), resulting in roughly 52,550 fatalities anticipated as a result of this illness.

Exploring contemporary breakthroughs in utilizing vesicular nanocarriers for breast cancer therapy.

Breast cancer (BC) is a heterogeneous disease with various morphological features, clinicopathological conditions and responses to different therapeutic options, which is responsible for high mortality and morbidity in women. The heterogeneity of BC necessitates new strategies for diagnosis and treatment, which is possible only by cautious harmonization of the advanced nanomaterials. Recent developments in vesicular nanocarrier therapy indicate a paradigm shift in breast cancer treatment by providing an integrated approach to address current issues.

Scaffold hopping for designing of potent and selective CYP1B1 inhibitors to overcome docetaxel resistance: synthesis and evaluation.

Cytochrome P450 1B1, a tumor-specific overexpressed enzyme, significantly impairs the pharmacokinetics of several commonly used anticancer drugs including docetaxel, paclitaxel and cisplatin, leading to the problem of resistance to these drugs. Currently, there is no CYP1B1 inhibition-based adjuvant therapy available to treat this resistance problem. Hence, in the current study, exhaustive studies including scaffold hopping followed by molecular docking, three-dimensional quantitative structure-activity relationships (3D-QSAR), molecular dynamics and free energy perturbation studies were carried out to identify potent and selective CYP1B1 inhibitors.