Publications by authors named "Nastaran Nikounezhad"
Article Synopsis
- The study explored using near-infrared (NIR) and mid-infrared (MIR) spectroscopy combined with chemometrics to verify the authenticity of Iranian saffron and detect potential adulteration.
- The research found that NIR spectroscopy was more effective than MIR in identifying the origin of saffron samples, using methods like principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA).
- Moreover, PLSR analysis demonstrated that NIR outperformed MIR in estimating the level of adulteration, achieving high regression coefficients between 0.95 and 0.99.
Article Synopsis
- Fourier transform infrared (FTIR) spectroscopy is being explored for biological sample analysis but faces challenges like spectral distortion due to Mie scattering from cell size similarities with IR wavelengths.
- In this research, five factors influencing scattering—cell size, shape, granularity, circularity, and edge irregularities—were analyzed using real biological cell data to improve accuracy in FTIR analysis.
- An algorithm incorporating these factors demonstrated high accuracy, showing over 97% similarity with ATR-FTIR spectra across various cell lines, outperforming existing methods in precision and correctness.
Objective: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione. In the present study, the importance of initial or repeated exposure to cisplatin in glutathione dependent resistance was investigated.
View Article and Find Full Text PDFHuman Lung Carcinoma Reaction against Metabolic Serum Deficiency Stress.
Iran J Pharm Res
January 2016
Cancer treatment is still of the greatest challenges that health care providers and patients are facing. One of the unsolved problems in cancer treatment is cells' reaction to metabolic stress caused by harsh nutritional conditions around tumor. In order to be able to treat this disease properly, it is important to understand the true nature of the disease.
View Article and Find Full Text PDFArticle Synopsis
- Cancer treatment with cisplatin can lead to drug resistance, largely due to cellular defense mechanisms, particularly involving glutathione (GSH).
- The study examined how cisplatin affects intracellular GSH levels in various human cell lines, including both sensitive and resistant types.
- Results showed significant differences in GSH content between resistant and sensitive cell lines, suggesting that changes in GSH levels post-cisplatin exposure are more indicative of resistance than initial GSH levels, with GSH measurements potentially serving as predictors of cisplatin resistance.