From data to medical context: the power of categorization in healthcare.

In the rapidly evolving healthcare domain, the ability to structure and interpret contextual medical data is crucial for delivering personalized and efficient patient care. While many existing studies attempt to define medical context through diverse categorizations, they often lack completeness or applicability in the real-world healthcare domain. This paper introduces a novel and comprehensive context categorization model composed of fifteen well-defined categories, bridging the gap between theoretical models and practical requirements in telemonitoring systems for chronic disease management.

Protection of double-Holliday junctions ensures crossing over during meiosis.

Chromosomal linkages formed through crossover recombination are essential for accurate segregation of homologous chromosomes during meiosis. The DNA events of recombination are linked to structural components of meiotic chromosomes. Imperatively, the biased resolution of double-Holliday junction intermediates (dHJs) into crossovers occurs within the synaptonemal complex (SC), the meiosis-specific structure that mediates end-to-end synapsis of homologs during the pachytene stage.

The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line.

53BP1 plays a crucial role in regulating DNA damage repair pathway choice and checkpoint signaling in somatic cells; however, its role in meiosis has remained enigmatic. In this study, we demonstrate that the Caenorhabditis elegans ortholog of 53BP1, HSR-9, associates with chromatin in both proliferating and meiotic germ cells. Notably, HSR-9 is enriched on the X chromosome pair in pachytene oogenic germ cells.

mutation enhances and embryonic lethality in .

In mice, mutation of results in embryonic lethality, which is partially suppressed by mutation. In contrast, mutation of the BRCA1 ortholog, or its binding partner, , lead to only mild embryonic lethality. We show that in , and embryonic lethality is enhanced when ortholog, , is also mutated.

Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses.

Biological sex affects numerous aspects of biology, yet how sex influences different biological processes have not been extensively studied at the molecular level. Caenorhabditis elegans, with both hermaphrodites (functionally females as adults) and males, is an excellent system to uncover how sex influences physiology. Here, we describe a method to isolate large quantities of C.

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation-Part 2: Efficacy Against Biofilm-Associated Bacteria.

Background: Biofilm-associated bacteria have been observed in both breast implant revision and tissue expander-implant exchange surgeries. The utilization of antimicrobial solutions in breast surgery, especially those containing triple antibiotics (TAB) and/or 10% povidone-iodine (PI), may help reduce existing biofilm-associated bacteria, which is particularly important in a mature breast pocket that may contain residual bacteria from a previously colonized implant surface or, theoretically, bacteria that may arrive postoperatively through hematogenous spread.

Objectives: A series of in vitro assessments was performed to evaluate the antimicrobial utility of TAB and PI, either alone or in combination, against preformed biofilm-associated bacteria.

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation-Part 1: Efficacy Against Planktonic Bacteria.

Background: Planktonic bacteria can be inadvertently introduced during breast surgery procedures, which are hypothesized to lead to complications such as infection, capsular contracture, breast implant-associated anaplastic large cell lymphoma, and a prolonged local inflammatory response. The utilization of antimicrobial solutions such as triple antibiotic solution (TAB) and/or 10% povidone-iodine (PI) in breast pocket irrigation or implant soaking has been proposed to reduce planktonic bacterial attachment and potential complications.

Objectives: A series of in vitro assessments were performed to evaluate the antimicrobial utility of TAB and PI, either alone or in combination, against planktonic bacteria.

Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in .

Meiosis is regulated in a sex-specific manner to produce two distinct gametes, sperm and oocytes, for sexual reproduction. To determine how meiotic recombination is regulated in spermatogenesis, we analyzed the meiotic phenotypes of mutants in the tumor suppressor E3 ubiquitin ligase BRC-1-BRD-1 complex in male meiosis. Unlike in mammals, this complex is not required for meiotic sex chromosome inactivation, the process whereby hemizygous sex chromosomes are transcriptionally silenced.

Matrix Topographical Cue-Mediated Myogenic Differentiation of Human Embryonic Stem Cell Derivatives.

Biomaterials varying in physical properties, chemical composition and biofunctionalities can be used as powerful tools to regulate skeletal muscle-specific cellular behaviors, including myogenic differentiation of progenitor cells. Biomaterials with defined topographical cues (e.g.

Impact of cardiac arrest resuscitated donors on heart transplant recipients' outcome.

Objective: To evaluate the influence of cardiac arrest-resuscitated donors (CARDs) on the outcome of heart recipients.

Methods: Patients transplanted between July 2004 and December 2012 were divided into 2 groups according to the history of cardiac arrest in donors and their clinical records were retrospectively reviewed.

Results: A total of 584 heart transplantations were performed during the study period, and 117 recipients received an organ from a CARD.