An easy to apply tube gel for lidocaine induced pain relief and 2-deoxy-d-ribose accelerated wound healing.

Many wounds can be challenging to manage because of pain and poor angiogenesis. An ideal treatment for such wounds would be a gel that can induce angiogenesis to accelerate wound healing and to reduce pain. Our aim in this study was to explore combining 2-deoxy-d-ribose (2dDR) to induce angiogenesis with lidocaine hydrochloride to reduce pain in the form of a tube-based gel.

Thin-film nanocomposite membranes for efficient removal of emerging pharmaceutical organic contaminants from water.

Membranes are receiving significant attention to remove emerging organic micropollutants (OMPs) from wastewater and natural water sources. Herein, we report the facile preparation of a novel thin-film nanocomposite (TFN) membrane with high permeability and efficient removal of OMPs. ZnO nanoparticles were first synthesized using the co-precipitation method and functionalized with N1-(3-Trimethoxysilylpropyl)diethylenetriamine to make the surface rich with amine groups and then synthesized nanomaterials were covalently cross-linked into the active layer during the interfacial polymerization (IP) process.

Evaluating dye recovery and reusability potential from dyebath effluent using forward osmosis membranes for minimum liquid discharge.

This study focuses on the evaluation of dye recovery and reuse potential from denim and polyester effluents using forward osmosis (FO). A cationic surfactant, tetraethylammonium bromide (TEAB), was used as the draw solution (DS). After optimizing the DS and feed solution (FS) concentrations and temperatures in batch experiments, a DS concentration of 0.

Design of moving average chart and auxiliary information based chart using extended EWMA.

The control chart is the most valuable tool in the manufacturing process to track the output process in the industries. Quality specialists always want a visual framework that recognizes sustainable improvements in the monitoring processes. The efficiency of a control chart is increased by utilizing a memory-based estimator or by using any extra information relevant to the key variable.

Risk reduction via spatial and temporal visualization of road accidents: a way forward for emergency response optimization in developing countries.

To achieve an effective emergency response and road safety, this study aims to assist a semi-automated dynamic system to analyze and predict the spatial distribution and temporal pattern of road crashes. Kasur, an intermediate city of Pakistan, was selected and data including location, time and reasons of accidents for five years (2014-2018) was utilized. Radar charts, Getis-Ord Gi* statistic, Moran's I spatial auto-correlation, and time series indices were engaged to present temporal, spatial and spatial-temporal variation of accidents, using python-based tools and jupyter notebook.

Recovering and reuse of textile dyes from dyebath effluent using surfactant driven forward osmosis to achieve zero hazardous chemical discharge.

This experimental study explores the feasibility of the reuse of dyes recovered from denim and polyester dyebath effluents using forward osmosis (FO) system to achieve zero hazardous material discharge. In batch experiments, the sodium dodecyl sulfate (SDS) at 0.5 M concentration generated an average flux of 3.

Intelligent breast cancer diagnostic system empowered by deep extreme gradient descent optimization.

Cancer is a manifestation of disorders caused by the changes in the body's cells that go far beyond healthy development as well as stabilization. Breast cancer is a common disease. According to the stats given by the World Health Organization (WHO), 7.

Impact of Pharmacist-Led Diabetes Self-Care Education on Patients With Type 2 Diabetes in Pakistan: A Randomized Controlled Trial.

There is a little evidence on efficacy of pharmacy-based interventions on clinical outcomes of type 2 diabetes mellitus (T2DM) patients in Pakistan. To appraise the impact of pharmacist-led self-care education on glycemic control, self-care practices and disease knowledge of T2DM patients with poor glycemic control (HbA1c ≥ 7%). In this 6-months, randomized controlled trial (RCT), = 75, T2DM patients seeking care at a diabetes clinic were randomized in to two groups.

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.

Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (N = 48,072, N = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo.

Diazotrophs for Lowering Nitrogen Pollution Crises: Looking Deep Into the Roots.

During and after the green revolution in the last century, agrochemicals especially nitrogen (N) were extensively used. However, it resulted in a remarkable increase in crop yield but drastically reduced soil fertility; increased the production cost, food prices, and carbon footprints; and depleted the fossil reserves with huge penalties to the environment and ecological sustainability. The groundwater, rivers, and oceans are loaded with N excess which is an environmental catastrophe.

Intelligent Cardiovascular Disease Prediction Empowered with Gradient Descent Optimization.

Disorders of the heart and blood vessels are named cardiovascular disease. 'The heart's proper functionality is of an utmost necessity for the survival of life. The death rate due to heart disease, has been increased rapidly.

Investigation of flux stability and fouling mechanism during simultaneous treatment of different produced water streams using forward osmosis and membrane distillation.

Forward osmosis-membrane distillation (FO-MD) hybrids were recently found suitable for produced water treatment. Exclusion of synthetic chemical draw solutions, typically used for FO, can reduce FO-MD operational costs and ease its onsite application. This study experimentally validates a novel concept for the simultaneous treatment of different produced water streams available at the same industrial site using an FO-MD hybrid system.

Prevalence and determinants of restless leg syndrome in type 2 diabetes mellitus (T2DM) in Pakistan.

Background And Aims: Restless legs syndromes (RLS) are intrinsic sleeping disorder and its prevalence rate is 10-15% in general population but it is observed that prevalence rate is different in diabetes patients. Current study aims to find prevalence and determinants of RLS in people living with type 2 diabetes mellitus in Pakistan.

Method: A multicenter cross-sectional observational study was conducted in 388 diabetes patients attending daily diabetes clinics and teaching hospitals in Pakistan's twin city between August 2019 and February 2020.

Development and validation of scale for self evaluation of soft skills in postgraduate dental students.

Objective: To develop and validate a soft skills questionnaire, and to use it for self-evaluation by postgraduate dentistry students.

Methods: The cross-sectional descriptive study was conducted at University College of Dentistry, , University of Lahore, Lahore, Pakistan, from February 2020 to April 2020 and comprised of residents from first to final year of training for either Masters in Dental Surgery or Fellowship of the College of Physicians and Surgeons Pakistan programmes. A soft skills questionnaire was generated and was validated through exploratory factor analysis of the elements and items of the questionnaire using SPSS 23.

Seed inoculation of desert-plant growth-promoting rhizobacteria induce biochemical alterations and develop resistance against water stress in wheat.

Water shortage limits agricultural productivity, so strategies to get higher yields in dry agricultural systems is vital to circumvent the effect of climate change and land-shortage. The plant rhizosphere harbors beneficial bacteria able to confer biotic/abiotic tolerance along with a positive impact on plant growth. Herein, three bacterial strains, Proteus mirabilis R2, Pseudomonas balearica RF-2 and Cronobacter sakazakii RF-4 (accessions: LS975374, LS975373, LS975370, respectively) isolated from native desert-weeds were investigated for their response to improve wheat growth under drought stress.

Improving access to the treatment of hepatitis C in low- and middle-income countries: evaluation of a patient assistance programme.

Background Modern antiviral treatments have high cure rates against the hepatitis C virus however, the high cost associated with branded medicines and diagnostic tests, have resulted in poor access for many low-income patients residing in low-and-middle-income countries. Objective This study aimed to evaluate the role of a patient assistance programme and generic medicines in improving access to treatment of low-income hepatitis C patients in a low-and-middle-income country. Setting A major teaching public hospital in Islamabad, Pakistan.

Large genome-wide association study identifies three novel risk variants for restless legs syndrome.

Restless legs syndrome (RLS) is a common neurological sensorimotor disorder often described as an unpleasant sensation associated with an urge to move the legs. Here we report findings from a meta-analysis of genome-wide association studies of RLS including 480,982 Caucasians (cases = 10,257) and a follow up sample of 24,977 (cases = 6,651). We confirm 19 of the 20 previously reported RLS sequence variants at 19 loci and report three novel RLS associations; rs112716420-G (OR = 1.