Role of traditional vs social media on purchase intention: A sequential mediation model.

In an increasingly saturated media environment, this study examines how traditional and social media influence consumer purchase intentions in the fashion industry through nostalgia, perceived credibility, and persuasion knowledge. Drawing on the Elaboration Likelihood Model (ELM), survey data from fashion-conscious consumers in Pakistan were analyzed using structural equation modeling. The results show that both media types evoke nostalgia and enhance credibility, which in turn reduce persuasion knowledge and strengthen purchase intentions.

Impact of Foliar Spray of Salicylic Acid on Morpho-Physiological and Biochemical Responses of Pea (Pisum sativum L.) under Drought Stress.

Drought stress reduces growth, yield, and photosynthetic efficiency in pea plants, limiting nutrient uptake and requiring mitigation strategies. Salicylic acid plays a key role in plant development, and pea (Pisum sativum L.) ranks fourth in global production.

Malaria vector control strategies in Pakistan: a scoping review.

Background: Malaria remains a significant public health concern in Pakistan due to its subtropical climate and diverse array of vectors, which contribute to periodic outbreaks and challenges in disease control. Recent outbreaks-particularly in 2022-along with the rising incidence of Plasmodium falciparum and growing resistance of Anopheles mosquito vector to existing control methods, highlight a critical gap in understanding the effectiveness of current malaria vector control strategies. This article is a scoping review of published literature on malaria prevention methods with a focus on World Health Organization (WHO) outlined interventions in the endemic region of the lower middle-income country, Pakistan.

Diagnostic Dilemmas in Giant Cell Arteritis: Overcoming Anchoring Bias.

Giant cell arteritis (GCA), also known as temporal arteritis, is the most common systemic vasculitis in individuals over 50 and presents diagnostic challenges due to its nonspecific symptoms such as fever, headache, and fatigue. This case report describes the details of a male patient in his 70s who presented with recurrent intermittent fevers of unknown origin and was ultimately diagnosed with GCA after an extensive workup. His initial CT scans and lab tests were unremarkable.

Electrical stimulation of stem cell-derived human neural networks for evaluating anti-seizure medications.

Objective: Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human-induced pluripotent stem cell (hiPSC)-derived cortical neurons cultured on multielectrode arrays (MEAs), capable of generating precisely controlled after-discharges (ADs) through electrical stimulation. We optimized stimulation parameters to evoke epileptiform-like hypersynchronous events and validated the model using six approved antiseizure medications (ASMs).

Exploring the Influence of Oral Health on Pregnancy Outcomes: A Narrative Review: Oral Health and Pregnancy Outcomes.

Oral health significantly impacts overall health, with increasing evidence linking poor oral health to adverse pregnancy outcomes. Periodontal disease, a chronic gum condition, is associated with preterm birth, low birth weight, and preeclampsia. Systemic inflammation and bacterial translocation are proposed mechanisms connecting periodontal disease to pregnancy complications.

Indium-Induced Toxicity Disrupts Redox Balance, Impairs Photosynthesis, and Induces Cell Wall Lignification in .

Indium pollution from high-tech industries and e-waste is an emerging environmental concern, posing risks to crop health and food safety. Despite its increasing presence in agricultural ecosystems, the phytotoxic effects of indium and the underlying tolerance mechanisms in crops remain largely unknown. This study investigates physiological, biochemical, and molecular responses of two L.

Muscle impairments in osteogenesis imperfecta: a narrative review.

The aim of this review is to provide an overview of the available evidence on the effects of OI on skeletal muscle. This encompasses multiple components of muscle function, underlying biological and environmental factors, clinical and functional consequences, and relevant epidemiology and therapeutic options. OI is a rare connective tissue disorder causing bone fragility and skeletal deformity, and extraskeletal features, including cardiac and dental abnormalities and hearing loss.

Adaptive responses of trees to industrial pollution: modulation of leaf anatomical, physio-biochemical, and heavy metal accumulation traits in urban biotopes.

Urbanization and industrialization have introduced complex environmental challenges, particularly concerning air pollution caused by industrial emissions. This study evaluates the adaptive responses of Cassia fistula, Pongamia pinnata, Ficus religiosa, and Ficus virens in polluted urban-industrial environments. Data was collected from five urban biotopes, including residential area (control) and industrial zones: crockery (site 1), iron and steel (site 2), sanitary (site 3), and auto parts industries (site 4), on the growth of broadleaved tree species.

Peroxisome Proliferator-Activated Receptor (PPAR) Agonists for Patients With Primary Biliary Cholangitis With Inadequate Response to Ursodeoxycholic Acid (UDCA): A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: Peroxisome proliferator-activated receptor (PPAR) agonists are agents used for patients with primary biliary cholangitis (PBC) who do not respond to conventional agents like ursodeoxycholic acid (UDCA). This meta-analysis aimed to assess the safety and efficacy of PPAR agonists, including fibrates and selective PPAR agonists, on biochemical response and safety outcomes in patients with primary biliary cholangitis who were non-responders to UDCA.

Methods: We searched various electronic databases, including MEDLINE (via PubMed), Embase, the Cochrane Library, and ClinicalTrials.

Double burdened yet resilient: quality of life of caregivers of people with X-linked hypophosphatemia.

X-linked hypophosphatemia (XLH) is a rare genetic disorder that leads to rickets, osteomalacia, and other skeletal abnormalities. Many people with XLH get support from informal caregivers, often family members, to help with their daily living. Although generally rewarding, being a caregiver can be associated with extra physiologic, physical, and mental health burdens, which are poorly researched and understood.

Tapia's Syndrome Secondary to Prolonged Intubation and Tracheostomy in a Patient With Opioid Dependence With Spontaneous Recovery.

Tapia syndrome is known as a rare complication characterized by neurologic deficits involving the hypoglossal nerve (XII) and recurrent laryngeal branch of the vagal nerve (X). It can occur after airway manipulation, including intubation. Typical signs and symptoms include dysphagia and dysphonia.

Genome-wide identification of NHX gene family and effects of salicylic acid in regulating antioxidant activity as well as nutrients deposition under salt stress in three Brassica species.

Background: The Na/H antiporter () gene subfamily is essential for plant adaptation to salt stress, contributing significantly to ion homeostasis. These antiporters play crucial function in various biological processes by regulating Na and H balance within plant cells. Yet their genomic features and roles of salicylic acid (SA) in regulating them, activating antioxidant defense mechanisms as well as nutrients acquisition under salt stress conditions remain largely unknown in many crop species.

The influence of perceived high-performance work systems on innovative work behavior: Mediating role of work engagement.

BackgroundThe principle of HRM requires employees to come up with novelty and creative ideas in work organizations. Prior research viewed high-performance work systems (HPWS) as an essential factor that promotes innovation and performance outcomes as it encourages employee creativity, risk-taking, and experimentation.ObjectiveThe current study investigated the influence of HPWS on innovative work behavior in medium-sized manufacturing enterprises through work engagement.

Impact of demographic variables on interplay of workplace bullying, organizational culture, and organizational performance: SEM-based multi group analysis.

BackgroundWorkplace bullying and organizational culture are two crucial factors that can significantly affect organizational performance. Understanding the interplay between these variables is imperative for creating conducive work environment and enhancing overall productivity. Additionally, demographic variables such as gender, age, designation, and work experience may also influence these dynamics within an organizational setting.

A literature review of the healthcare resource use and productivity burden of X-linked hypophosphataemia.

Introduction: X-linked hypophosphataemia (XLH) is a rare, genetic, renal phosphate wasting disorder that causes a lifelong rapid progression of morbidities, which are associated with substantial humanistic and economic burden. A structured literature review was carried out to identify publications reporting healthcare resource use and productivity impact of XLH to provide a comprehensive description of the burden.

Methods: Literature searches of the Embase®, Medline®, and EconLit electronic databases were carried out in August 2022 using free-text and subject heading search terms regarding XLH-related clinical morbidities and associated healthcare resource use, limited to English language records from 1992 onwards.

X-Linked Hypophosphatemia Management in Adults: An International Working Group Clinical Practice Guideline.

Purpose: An international working group (IWG) consisting of experts in X-linked hypophosphatemia (XLH) developed global guidelines providing a comprehensive, evidence-based approach to XLH diagnosis, management, and monitoring.

Methods: The IWG, consisting of 43 members as well as methodologists and a patient partner, conducted 2 systematic reviews (SRs) and narrative reviews to address key areas. The SRs addressed the impact of burosumab compared to conventional therapy (phosphate and active vitamin D) or no therapy on patient-important outcomes in adults.

Beyond Acute Overdoses: A Case of Chronic Clozapine Toxicity With Non-specific Presentation.

Clozapine is recognized as the gold standard for treating treatment-resistant schizophrenia but carries a notable risk of severe adverse effects. This case report presents a 61-year-old Welsh woman with paranoid schizophrenia and epilepsy who, while on long-term clozapine and valproic acid therapy, developed a progressive decline in mobility, cognition, and social engagement, punctuated by recurrent falls. Despite numerous hospital visits and extensive investigations, the underlying cause of her symptoms remained elusive until serum clozapine level testing revealed toxicity, with levels significantly exceeding the therapeutic range.

In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review.

Valproic acid (VPA) is a first-line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug has become highly regulated/restricted for women of childbearing potential. This includes those who have been shown to respond well to the drug and respond poorly to alternative ASMs.

Mobility and Quality of Life in Adults with Paediatric-Onset Hypophosphatasia Treated with Asfotase Alfa: Results from UK Managed Access Agreement.

Introduction: Hypophosphatasia (HPP) is a rare disease caused by deficient tissue-non-specific alkaline phosphatase (ALP) activity. Asfotase alfa is a tissue-non-specific ALP enzyme-replacement therapy which was reimbursed in the UK under a Managed Access Agreement (MAA). This analysis assessed safety and effectiveness of asfotase alfa in adults with HPP.

Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults.

The guideline panel, comprising international experts in X-linked hypophosphatemia (XLH), patient partners from the XLH patient population, and guideline methodologists, held 18 teleconferences between January 2023 and July 2024 to develop comprehensive guidelines for the diagnosis and management of XLH in children and adults. For a subset of our questions, we utilized the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology, assessed the certainty of evidence and formulated GRADEd recommendations. For these questions, the panelists and methodologists collaboratively framed PICO (Population, Intervention, Control, and Outcomes) questions and conducted four systematic reviews assessing the impact of medical therapy-using either burosumab or phosphate and active vitamin D-on patient-important outcomes in the XLH population as well as the impact of medical intervention compared to no treatment.

Current Practices in Monitoring Children and Adults With X-linked Hypophosphatemia: A Global Survey of Expert Experience.

This report provides recommendations for X-linked hypophosphatemia (XLH) monitoring based on current monitoring practices of experts in the management of XLH in children (<18 years) and adults. We surveyed 43 international experts in XLH to determine their monitoring practices for children and adults with XLH, including pregnant and lactating women. In the initial evaluation of children and adults with XLH, experts consistently obtain a family history of XLH or hypophosphatemia, a history of fractures and dental infections, and assess pain through age-appropriate clinical interviews or caregiver reports.