Recent Advances in Technologies for Preserving Fresh-Cut Fruits and Vegetables.

Rapid economic growth and changing consumer patterns have made fresh-cut fruits and vegetables household staples because of their high nutritional value, their role in reducing the risk of illnesses and other health problems, and convenience. However, fresh-cut produce is susceptible to the rapid deterioration of sensory quality, nutrient loss, foodborne pathogens contamination, and spoilage caused by microbial growth, which can lead to consumer health risks. Thus, there is an urgent need to improve preservation methods, to increase the shelf life of fresh-cut produce.

Expression of immune checkpoints (IDO and PD-L1) in oral tongue cancer patients: a 10-year retrospective cohort study in Pakistan.

Background: Tongue squamous cell carcinoma (TSCC) is a significant global health issue with high incidence and mortality rates. Current treatments involve surgery, radiotherapy, and chemotherapy; however, prognosis remains poor. Recent research highlights the crucial role of the tumor microenvironment, especially immune cells and checkpoints like PD-L1 and IDO, in TSCC progression.

Anti-Inflammatory Effect of Goat Milk Against Acetic Acid-Induced Ulcerative Colitis in Rat Model.

The current study evaluated the protective and antioxidant effects of goat milk, alone and in combination with sulfasalazine (SAZ), against acetic acid (AA)-induced ulcerative colitis (UC) in Sprague Dawley rats. Thirty rats were divided into five groups with six rats in each group. UC was induced using 3% AA, administered intrarectally (IR) at a dose of 3 mL per rat once daily for the first three consecutive days of the experiment.

Cystic Duct Stenting Versus Other Treatment Modalities for the Management of Acute Cholecystitis in Patients with Decompensated Cirrhosis.

Background And Aims: The incidence of cholecystitis and cholelithiasis is higher in patients with cirrhosis. Decompensated liver disease places them at higher risk for morbidity and mortality from cholecystectomy, and many providers prefer non-surgical approaches. We compared cystic duct stenting (CDS) to other modalities mainly percutaneous cholecystostomy (PC), cholecystectomy, and medical management.

Monitoring and enforcement of Code-based legal measures to protect breastfeeding in South Asia: opportunities and bottlenecks.

Objective: To examine the bottlenecks and opportunities associated with Code monitoring and enforcement at the national level in the eight countries of South Asia region (Afghanistan, Bhutan, Bangladesh, India, Maldives, Nepal, Pakistan, and Sri Lanka).

Design: Data was collected following a workshop-as-research methodology. Deductive content analysis was used to review, categorize, and analyze data.

Insights from the rapid implementation of digital technologies in nursing practice during COVID-19 - a survey.

Aim: To explore nurses' adoption of digital technologies during the COVID-19 pandemic and their perceived impact on nursing practice in Australia, focusing on technology-supported workforce preparedness for future public health emergencies.

Design: A cross-sectional survey design.

Methods: Nurses who worked in clinical settings during the COVID-19 lockdown period were eligible to participate in this study.

Endocuff-Assisted Colonoscopy for Identifying Sessile Serrated Polyps and Adenomas During Routine Colorectal Cancer Screening: A Retrospective Cohort Study.

Background And Aims: Polyps located in less accessible areas of the colon, such as inner curves of flexures, are often difficult to visualize. Colonoscope attachments such as the Endocuff have been developed to improve the visualization of these polyps. We aimed to assess the utility of Endocuff-assisted colonoscopy (EAC) in the detection of tubular adenomas and sessile serrated polyps (SSP) compared to conventional colonoscopy during routine colorectal cancer screening.

Physiological and Immunomodulatory Effects of Purslane Extract in Juveniles: Implications for Sustainable Production.

Medicinal plants are rich in nutrients and bioactive compounds, making them potentially suitable for use as chemotherapeutic agents and as additives in aquafeed. Our research evaluated the effects of purslane () extract supplemented in sunflower-based diets on the growth, carcass composition, blood indices, mineral content, liver antioxidant enzyme profile, and immune response in (8.26 0.

Synergistic Antioxidant and Antidiabetic Effects of Caesalpinia bonduc (L.) and Gymnema sylvestre (Retz.) in Alloxan-Induced Diabetic Rats.

Caesalpinia bonduc (L.) and Gymnema sylvestre (Retz.) are traditional remedies for diabetes management.

Optimizing the impact of time domain segmentation techniques on upper limb EMG decoding using multimodal features.

Neurological disorders, such as stroke, spinal cord injury, and amyotrophic lateral sclerosis, result in significant motor function impairments, affecting millions of individuals worldwide. To address the need for innovative and effective interventions, this study investigates the efficacy of electromyography (EMG) decoding in improving motor function outcomes. While existing literature has extensively explored classifier selection and feature set optimization, the choice of preprocessing technique, particularly time-domain windowing techniques, remains understudied posing a significant knowledge gap.

Epidemiology, Survival, and Second Primary Malignancies in T-Cell Large Granular Lymphocytic Leukemia.

Introduction: Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.

Methods: The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.

Results: Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.

Assessing the effectiveness of texture and color enhancement imaging versus white-light endoscopy in detecting gastrointestinal lesions: A systematic review and meta-analysis.

Introduction: Gastrointestinal cancers account for 26% of cancer incidence and 35% of cancer-related deaths globally. Early detection is crucial but often limited by white light endoscopy (WLE), which misses subtle lesions. Texture and color enhancement imaging (TXI), introduced in 2020, enhances texture, brightness, and color, addressing WLE's limitations.

Advancing Enzyme-Based Detoxification Prediction with ToxZyme: An Ensemble Machine Learning Approach.

The aaccurate prediction of enzymes with environment detoxification functions is crucial, not only to achieve a better understanding of bioremediation strategies, but also to alleviate environmental pollution. In the present study, a novel machine learning model was introduced which classifies enzymes by their toxin degradation ability. In this model, two different sets of data were used which include enzymes that can catalyze the toxin degradation as a positive dataset and non-toxin-degrading enzymes as a negative dataset.

Predictive Factors of Post-ERCP Hepatic Decompensation in Patients with Cirrhosis: A Retrospective Case-Control Study.

Background And Aim: Endoscopic retrograde cholangiopancreatography (ERCP) is a crucial diagnostic and therapeutic procedure in patients with cirrhosis; however, it carries the risk of post-procedural hepatic decompensation. This study aims to identify predictive factors associated with post-ERCP hepatic decompensation in patients with cirrhosis to better inform clinical decision-making and minimize adverse outcomes.

Methods: A retrospective analysis was conducted on patients with cirrhosis undergoing ERCP.

Tailored metal-insulator-metal multilayer design for perfect ir absorption at desired wavelengths in stealth systems.

The plasmonic-based metamaterial has been designed with a metal-insulator-metal (MIM) structure for applying IR stealth technology. The design of two MIM unit cell structures was composed of five stacked layers. The numerical simulation showed that the designed MIM structure exhibited dual absorption peaks at resonant wavelengths of 1.

Outcomes in patients with classic Hodgkin lymphoma refractory or intolerant to brentuximab vedotin and anti-PD-1 therapy: a real world analysis from 15 U.S. academic centers.

Anti-PD-1 based therapies and brentuximab vedotin (BV) have significantly improved survival in patients with classic Hodgkin lymphoma (cHL) and have been incorporated into earlier lines of therapy. However, there is insufficient data regarding the clinical outcomes in patients who develop refractory disease or who become intolerant of BV and anti-PD-1 therapies (double refractory/intolerant; DR/INT). Here, we evaluated outcomes in patients with DR/INT cHL from 15 US academic medical centers.

Connecting Bone Remodeling and Regeneration: Unraveling Hormones and Signaling Pathways.

Recent advancements in tissue engineering and stem cell science have positioned bone disease treatment as a promising frontier in regenerative medicine. This review explores the hormonal and signaling pathways critical to bone regeneration, with a focus on their clinical relevance. Key endocrine factors, including thyroid hormones (T3 and T4), insulin-like growth factor 1 (IGF-1), bone morphogenetic proteins (BMPs), parathyroid hormone (PTH), calcitonin, and fibroblast growth factor 23 (FGF23), play pivotal roles in bone remodeling by regulating osteoblast activity, bone resorption, and mineralization.

Evaluating the Effectiveness of Pegbelfermin in MASH-Associated Hepatic Fibrosis A Meta-Analysis and Systematic Review of Randomized Controlled Trials.

Introduction: Metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of fatty liver disease, is characterized by liver inflammation and fibrosis, with an emerging interest in fibroblast growth factor (FGF)-21 analogs, particularly pegbelfermin (PGBF). This study evaluates the efficacy and safety of PGBF in treating MASH-associated hepatic fibrosis.

Methods: This meta-analysis followed Cochrane guidelines and PRISMA standards.

Malignant Arrhythmia and Cardiac Arrest Following Intentional Yew Tree Leaf Ingestion Salvaged by VA-ECMO.

This case emphasizes the role of multidisciplinary involvement and early decision-making in yew tree ( poisoning. contains taxine alkaloids that predispose to malignant arrhythmia. Here, we present a case of toxicity presenting with refractory cardiac arrest, salvaged ultimately by VA-ECMO.

Analysis of Adverse Events of Endoscopic Ultrasound-Guided Lumen-Apposing Metal Stent Placement: Insights Across Various Indications and Techniques.

Background: Endoscopic ultrasound (EUS)-guided lumen-apposing metal stent (LAMS) placement is increasingly being used of surgery for multiple procedures, including transmural fluid drainage. However, few studies have evaluated adverse events (AEs) associated with LAMS placement. Our aim was to characterize the rates of AEs associated with several LAMS placement strategies across different procedures and indications.

Assessing Clinical Value of New Treatment Strategies: ESMO-MCBS and ASCO-VF Evaluation in Phase III Trials at ASCO Annual Meeting 2022.

Purpose: The European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) and the ASCO Value Framework (ASCO-VF) are tools designed to assess the value of anticancer therapies. International conferences are the primary venues for sharing trial outcomes, often influencing clinical practices even before full publications are available. This analysis compares the ESMO-MCBS and ASCO-VF in evaluating the benefit of all phase III trials presented at the 2022 ASCO Annual Meeting (AM) and to examine the level of agreement between these scales.

Crossing the Boundaries of Conflict: Analyzing Epidemiology & Outcomes of Afghan Oral Squamous Cell Carcinoma Patients at a Pakistani Cancer Hospital.

Background: This study investigates oral cavity squamous cell carcinoma (OSCC) among Afghan patients treated at a Pakistani cancer center, focusing on epidemiology, tumor characteristics, outcomes, and healthcare challenges faced by patients from conflict-affected regions.

Methods: A retrospective analysis of Afghan OSCC patients (2010-2023) was conducted. Demographic, clinical, and treatment data were evaluated, with survival outcomes analyzed using Kaplan-Meier survival analysis.

PBPK-Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population.

Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk-to-plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five antimalarials with clinical lactation data (chloroquine, pyrimethamine, piperaquine, mefloquine and primaquine). In all cases, RID was correctly categorized as above or below the WHO proposed cut-off of 10% using two prediction models.