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Article Abstract
Introduction: Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.
Methods: The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.
Results: Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.
Conclusion: Patients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.
Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053475 | PMC |
| http://dx.doi.org/10.1002/jha2.70036 | DOI Listing |
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