Safety and Efficacy of Remibrutinib for Chronic Spontaneous Urticaria, a Systematic Review and Meta-analysis.

Background: Chronic spontaneous urticaria (CSU) is a burdensome condition marked by recurrent wheals and/or angioedema lasting over six weeks. Despite current treatments, many patients remain symptomatic. Remibrutinib, a selective Bruton's tyrosine kinase (BTK) inhibitor, is a promising therapy targeting mast cell degranulation.

Effect of magnetically guided capsule endoscopy on gastrointestinal transit time and diagnostic yield: a systematic review and meta-analysis.

Background: Capsule endoscopy (CE) is a primary tool for small bowel visualization, but its diagnostic yield can be limited by prolonged transit times and finite battery life. Various interventions, including prokinetics, purgatives, and magnetic steering, are used to optimize CE performance. This systematic review and meta-analysis compare the effectiveness of these strategies in improving transit times and completion rates.

Challenges and Advances in Saphenous Vein Graft Perforation During Percutaneous Coronary Intervention: Incidence, Risk Factors, Management and Prophylactic Strategies.

Saphenous vein grafts (SVGs) remain the most commonly used conduits in coronary artery bypass grafting, but their high failure rates necessitate repeated revascularization in many cases. SVG perforation, although rare, is a severe complication that can result in cardiac tamponade, myocardial infarction, or death if not promptly managed. Three main stages describe SVG failure pathophysiology, starting with thrombosis, followed by intimal hyperplasia, and progressing to atherosclerosis later in the process.

Diagnostic Test Accuracy of Cytosponge-Trefoil Factor 3 for Barrett Esophagus: A Systemic Review and Meta Analysis.

Introduction: Barrett's esophagus (BE), characterized by the replacement of normal esophageal squamous epithelium with columnar metaplasia, poses a risk of progression to esophageal adenocarcinoma. Early detection is essential to prevent malignant transformation. The Cytosponge, a novel, minimally invasive cell collection device, has been proposed as a diagnostic tool for BE by identifying trefoil factor 3 (TFF3)-positive cells.

Intravenous thrombolysis as an adjunct to endovascular thrombectomy in acute basilar artery occlusion: a GRADE-assessed systematic review and meta-analysis.

Acute basilar artery occlusion (BAO) is a rare but devastating type of ischemic stroke that significantly impacts outcomes. This systematic review and meta-analysis aim to evaluate the efficacy and safety of combining IVT with EVT (EVT + IVT) versus EVT alone in treating acute BAO, focusing on functional independence, mortality, reperfusion success, and hemorrhagic and procedural complications. We conducted a comprehensive search up to May 2025.

Recombinant human pro-urokinase vs. alteplase within 4.5 hours of acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials.

Background: Recombinant human pro-urokinase (rhPro-UK) has emerged as a potential alternative to alteplase for patients with acute ischemic stroke (AIS) presenting within 4.5 hours of symptom onset. This meta-analysis evaluates and compares the efficacy and safety of rhPro-UK with alteplase in this patient population.

The Cusp Overlap Technique Reduces Pacemaker Implantation in TAVR: A Systematic Review and Meta-analysis.

Transcatheter aortic valve replacement (TAVR) has become the preferred treatment for symptomatic aortic stenosis, yet conduction disturbances leading to permanent pacemaker implantation (PPI) remain a significant complication, particularly with self-expanding valves (SEVs). The cusp overlap view (COV) technique has been introduced to achieve a higher, more controlled valve implantation compared to the conventional coplanar view (CPV). We performed a systematic review and meta-analysis (14 studies; 5,266 TAVR patients) comparing the COV to the CPV.

Effects of Dexmedetomidine on Acute Kidney Injury and Perioperative Outcomes in Aortic Vascular Surgery: A Systematic Review and Meta-Analysis.

Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, may help mitigate postoperative complications in patients undergoing aortic vascular surgery. A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identify studies assessing the efficacy and safety of dexmedetomidine compared with placebo in patients undergoing aortic vascular surgery. A random effects meta-analysis was performed with R version 4.

Efficacy and safety of colchicine post myocardial infarction: a systematic review, meta-analysis and meta-regression analysis of randomized clinical trials.

Background: Myocardial infarction (MI) triggers inflammation that affects post-MI outcomes. Colchicine shows potential in treating cardiovascular (CV) conditions; however, its role in reducing adverse CV events post-MI remains uncertain.

Methods: We conducted a thorough search across PubMed, Embase, Web of Science from inception to February 2025 for randomized controlled trials (RCTs) comparing colchicine and control in MI patients.

Efficacy and Safety of Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials.

Managing persistent atrial fibrillation (AF) remains challenging due to its complex arrhythmic substrate, and pulmonary vein isolation through catheter ablation remains the primary treatment. This meta-analysis aims to compare the efficacy and safety outcomes of cryoballoon ablation (CBA) and radiofrequency ablation (RFA) in patients with persistent AF to provide evidence-based insights for clinical decision-making. A systematic search of PubMed, Embase, and Cochrane Central was conducted following PRISMA guidelines.

Meta-Analysis on Comparison of Fasting Versus No Fasting Before Cardiac Catheterization.

Patients undergoing cardiac catheterization are advised not to take anything by mouth after midnight. However, limited scientific data exist on whether fasting before catheterization procedures improves clinical outcomes compared with nonfasting. A comprehensive literature search was performed by investigators using major bibliographic databases to identify studies that compared clinical outcomes for fasting versus nonfasting patient groups following cardiac catheterization procedures.

Intra rater reliability of Y balance test in medical students.

The cross-sectional study was planned to assess the Ybalance test's intra-rater reliability among a sample of 59 medical students. The subjects took six trials under supervision, and the reliability of the results improved, with intra-class correlation values >0.75, indicating high reliability.

Role of Renin-Angiotensin System Inhibitors After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-analysis.

Supplemental Digital Content is Available in the Text.

Innovative solid desiccant dehumidification using distributed microwaves.

Dehumidification is one of the key challenges facing the air conditioning (AC) industry in the treatment of moist air. Over many decades, the dual role of heat exchangers of AC chillers for the sensible and latent cooling of space has hindered the thermal-lift reduction in the refrigeration cycle due to the requirements of water vapor removal at dew-point and heat rejection to the ambient air. These practical constraints of AC chillers have resulted in the leveling of energy efficiency of mechanical vapor compressors (MVC) for many decades.

Small RNAs and Karma methylation in Elaeis guineensis mother palms are linked to high clonal mantling.

The mantled phenotype is an abnormal somaclonal variant arising from the oil palm cloning process and severe phenotypes lead to oil yield losses. Hypomethylation of the Karma retrotransposon within the B-type MADS-box EgDEF1 gene has been associated with this phenotype. While abnormal Karma-EgDEF1 hypomethylation was detected in mantled clones, we examined the methylation state of Karma in ortets that gave rise to high mantling rates in their clones.

"Crisis management in the hospitality sector SMEs in Pakistan during COVID-19″.

The COVID-19 pandemic has delivered one of the worst economic shocks in modern history and the hospitality sector has been severely affected. Since small businesses from the hospitality sector are known to be relatively more susceptible to the economic complications arising from a crisis, we explore the underlying factors and management practices that influence their continuity of operations as they continue to struggle with the on-going COVID-19 crisis in Pakistan. Using a phenomenological approach, in-depth interviews were conducted to comprehend the experiences of owners-managers.

A Universal Mathematical Methodology in Characterization of Materials for Tailored Design of Porous Surfaces.

Understanding adsorption phenomena is essential to optimize and customize the energy transformation in numerous industrial and environmental processes. The complex and heterogeneous structure of the adsorbent surface and the distinct interaction of adsorbent-adsorbate pairs are attributed to the diverse response of adsorption phenomena, measured by the state diagrams of adsorption uptake known as adsorption isotherms. To understand various forms of adsorption isotherms, the surface characteristics of the adsorbent surface with the heterogeneity of adsorption energy sites must be analyzed so that they can be modified for the tailored response of the material.

A Universal Theoretical Framework in Material Characterization for Tailored Porous Surface Design.

The distinct interaction of adsorbate-adsorbent pair is attributed to the characteristics of heterogeneous surface and structure of porous materials. In material science, the porous structure is modified in response to certain applications. Backed by the chemical recipes, such conventional approach rely on the material characterization techniques to verify the resultant porous structure and its interaction with the adsorbate molecules.

Desalination Processes' Efficiency and Future Roadmap.

For future sustainable seawater desalination, the importance of achieving better energy efficiency of the existing 19,500 commercial-scale desalination plants cannot be over emphasized. The major concern of the desalination industry is the inadequate approach to energy efficiency evaluation of diverse seawater desalination processes by omitting the grade of energy supplied. These conventional approaches would suffice if the efficacy comparison were to be conducted for the same energy input processes.

IoT Elements, Layered Architectures and Security Issues: A Comprehensive Survey.

The use of the Internet is growing in this day and age, so another area has developed to use the Internet, called Internet of Things (IoT). It facilitates the machines and objects to communicate, compute and coordinate with each other. It is an enabler for the intelligence affixed to several essential features of the modern world, such as homes, hospitals, buildings, transports and cities.

A Universal Isotherm Model to Capture Adsorption Uptake and Energy Distribution of Porous Heterogeneous Surface.

The adsorbate-adsorbent thermodynamics are complex as it is influenced by the pore size distributions, surface heterogeneity and site energy distribution, as well as the adsorbate properties. Together, these parameters defined the adsorbate uptake forming the state diagrams, known as the adsorption isotherms, when the sorption site energy on the pore surfaces are favorable. The available adsorption models for describing the vapor uptake or isotherms, hitherto, are individually defined to correlate to a certain type of isotherm patterns.