Publications by authors named "Mu-Lin Yao"
Background: Despite the lack of consensus, the use of inhaled nitric oxide (iNO) in preterm infants with a gestational age (GA) of less than 34 weeks has been increasing in recent years. At present, there are no multi-center studies in China on the use of iNO in this population. This study aims to investigate the use of iNO in preterm infants under 34 weeks of gestation over the past 10 years in China, and provides evidence-based medical proof for the use of iNO in these neonates.
View Article and Find Full Text PDFObjective: To analyse early risk factors for mortality in preterm infants treated with inhaled nitric oxide (iNO) in China.
Design: A retrospective observational case-control study.
Setting: 8 tertiary hospitals in 5 regions of China.
Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.
Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).
Article Synopsis
- This study examined the use and effects of inhaled nitric oxide (iNO) in preterm infants under 34 weeks gestational age across eight hospitals in China over a span of ten years.
- A total of 434 infants were analyzed, categorized into three gestational age groups: extremely preterm (24-27 weeks), very preterm (28-31 weeks), and moderate preterm (32-33 weeks), focusing on treatment outcomes and complications.
- Findings indicated that extremely preterm infants had the highest rates of iNO treatment and associated complications, with mortality rates inversely related to gestational age and birth weight, underscoring the importance of iNO in managing severe respiratory issues in this population.
A multicenter epidemiological survey of iNO use in preterm infants in China.
Pediatr Pulmonol
December 2024
Objective: To investigate the use of inhaled nitric oxide (iNO) in hospitalized preterm infants in China over 10 years and its clinical outcomes.
Methods: A total of 616 premature infants who were administered iNO in the Neonatology Departments of 5 Class A tertiary hospitals in China for ten years from January 2013 to December 2022 were included retrospectively. Based on their enrollment periods, the patients were divided into two groups: Group 1 from January 2013 to December 2017 and Group 2 from January 2018 to December 2022, respectively.