Immunoinformatics approach: Developing a multi-epitope vaccine with novel carriers targeting monkeypox virus.

Since May 2022, the global spread of monkeypox virus (MPXV) has presented a significant threat to public health. Despite this, there are limited preventive measures available. In this study, different computational tools were employed to design a multi-epitope vaccine targeting MPXV.

Long Non-Coding RNA and as a Promising Diagnostic and Prognostic Biomarker in Glioblastoma Multiforme.

Background: Glioblastoma multiforme (GBM) is one of the most invasive types of brain cancer. LncRNAs can be considered a new prognostic and diagnostic biomarker in GBM. This study comprehensively explored the interaction of lncRNAs with mRNAs in the TCGA database and proposed a novel promising biomarker with favorable diagnostic and prognostic values.

Unveiling the diagnostic potential of diffusion kurtosis imaging and intravoxel incoherent motion for detecting and characterizing prostate cancer: a meta-analysis.

Purpose: This study aims to assess the diagnostic capabilities of Diffusion Kurtosis Imaging (DKI) and Intravoxel Incoherent Motion (IVIM) in prostate cancer (PCa) detection and characterization.

Materials: A comprehensive search was conducted across PubMed, Scopus, Web of Science, and the Cochrane Library for articles published up to September 10, 2023, that evaluated the diagnostic efficacy of MD, MK, Dt, f, and Dp parameters. Data were pooled using a bivariate mixed-effects regression model and analyzed with R software.

Effect of collagen hydrogel containing essential oil nanoemulsion in wound healing of infectious burn.

Background And Objectives: The main cause of mortality in burn patients is infection from burns. Drug-resistant bacteria are the main causes of wound infection, so alternative antibiotic therapies hold significant importance. The objective of this study was to examine the impact of a collagen hydrogel that contains a nanoemulsion of essential oil on the healing process of infected burn wounds.

Developing a quality and safety assessment framework for Iran's military hospitals.

Background: The first crucial step towards military hospitals performance improvement is to develop a local and scientific tool to assess quality and safety based on the context and aims of military hospitals. This study introduces a Quality and Safety Assessment Framework (Q&SAF) for Iran's military hospitals.

Methods: This is a literature review which continued with a qualitative study.

Comparison of RT-LAMP and RT-qPCR assays for detecting SARS-CoV-2 in the extracted RNA and direct swab samples.

Rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected patients is critical for infection control. Loop-mediated isothermal amplification (LAMP) has been demonstrated to be a rapid, simple, reliable, cost-effective and sensitive method to detect SARS-CoV-2 in a variety of samples in considerably less time than Real-Time PCR. In this study, we developed and optimized a rapid detection method for SARS-CoV-2 based on RT-LAMP method utilizing a specific primer set targeting the ORF1a gene and then examined its sensitivity and efficiency using a serially diluted viral RNA sample with a known concentration.

Experiences of operating room nurses in disaster preparedness of a great disaster in Iran: a qualitative study.

Background: In recent years, Iran has encountered a growing frequency of earthquake disasters. Given that nurses constitute the largest group of healthcare providers, it is imperative that they possess adequate disaster preparedness skills, irrespective of the location or time. Despite the operating room nurses' roles in disasters, their experiences and challenges in disaster preparedness have been overlooked.

Lactobacillus casei condition medium downregulates miR-21 relative expression in HT-29 colorectal cancer cell line.

Previous research has demonstrated promising outcomes regarding the advantageous impact of probiotics in both cancer prevention and treatment. Nevertheless, the precise molecular mechanisms underpinning these effects remain elusive. Recent investigations have proposed a potential involvement of micro ribonucleic acids (miRNAs) in mediating the favorable influence of probiotics on cancerous cells.

Development and Psychometric Properties of the Caring Behaviors of Operating Room Nurses Questionnaire during the COVID-19 Pandemic: A Mixed-Method Study.

Background: Considering the threats in the operating room during the COVID-19 pandemic, the optimal care and safety of the operating room nurses should be maintained when performing surgery on an acute respiratory patient. It seems necessary to design a tool to measure the caring behaviors of operating room nurses. Therefore, the present study was conducted with the aim to design a valid and reliable tool for measuring the caring behavior of operating room nurses during the COVID-19 pandemic.

Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies.

Lymphoid cells play a critical role in the immune system, which includes three subgroups of T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in lymphopoiesis has revolutionized our understanding of the regulatory potential of RNA in normal lymphopoiesis and lymphoid malignancies. Long non-coding RNAs (lncRNAs) are a class of RNA molecules greater than 200 nucleotides in length.

Inhibition of bacterial adhesion and anti-biofilm effects of and biosurfactants against and .

Background And Objectives: Biosurfactants are amphiphilic surface-active agents that mainly produced by various microorganisms. In this study, the anti-biofilm and inhibition of bacterial adhesion activities of two bacterial biosurfactants were investigated.

Materials And Methods: After extraction and evaluation of and biosurfctants, inhibition of bacterial adhesion and anti-biofilm effects of them on and were determined.

Identifying the factors affecting on interaction of faculty member: A meta-synthesis.

Background: The ability to interact and communicate effectively is one of the factors affecting the performance of faculty members, which is considered one of their basic competencies. The purpose of this study was to identify the factors affecting on interaction of faculty member with student and colleague, through the synthesis of literature.

Materials And Methods: The research method was qualitative with a meta-synthesis approach.

Isolation of nontuberculous mycobacteria species from different water sources: a study of six hospitals in Tehran, Iran.

Purpose: Nontuberculous mycobacteria (NTM) are ubiquitous bacteria that are naturally resistant to disinfectants and antibiotics and can colonize systems for supplying drinking water. Therefore, this study aimed to evaluate the prevalence of NTM in the drinking water of six hospitals in Tehran, Iran.

Methods: Totally, 198 water samples were collected.

Exploring the components of student support system in blended learning for Iranian Universities of Medical Sciences: A thematic analysis.

Background: Support services are a very important element for all educational institutions. The aims of this study were to explore the components of the student support system in blended learning for universities of medical sciences in Iran.

Materials And Methods: The present study was performed qualitative with exploratory approach.

Molecular detection of in biopsy samples of intervertebral disc with modic changes in patients undergoing herniated disc surgery.

Background And Objectives: Recent studies have hypothesized that sterile disc infection with the anaerobic , recently renamed , occurs in people with intervertebral disc (IVD) herniation. This study aimed to examine the presence of in patients who have Low back pain (LBP) with Modic changes observed in their Magnetic Resonance Imaging (MRI).

Materials And Methods: Thirty-seven patients who were candidates for surgery due to disc herniation and demonstrated Modic changes in MRI were included in the study.

Identification of dimensions and indicators of spiritual health: A qualitative study.

Introduction: Spiritual health is considered one of the important dimensions of health and has been given serious attention by the scientific community, World Health Organization, health discourse, and medical education. However, despite these considerations, there is a controversy in defining the nature of this category and its dimensions and indicators. The purpose of this study is to identify the indicators and dimensions of spiritual health for medical students.

A Study on Capabilities Required In Military Medicine to Develop Modular Training Courses: A Qualitative Study.

Introduction: The main mission of military medicine in the world is to support the health and treatment of the military in relation to issues, risks, injuries and diseases that arise due to the specific occupational conditions. The current study was carried out with the aim of determining the required skills of military physicians to define and determine the required training modules.

Methods: The study was a qualitative research.

Designing a model for critical thinking development in AJA University of Medical Sciences.

Introduction: In the new concept of medical education, creativity development is an important goal. The aim of this research was to identify a model for developing critical thinking among students with the special focus on learning environment and learning style.

Methods: This applied and cross-sectional study was conducted among all students studying in undergraduate and professional doctorate programs in Fall Semester 2013-2014 in AJA University of Medical Sciences (N=777).