GC-MS profiling, in vitro and in silico antibacterial and antioxidant potential of crude secondary metabolites of an endophytic bacterium isolated from Enhydra fluctuans lour.

This study investigates the bioactive potential of secondary metabolites produced by endophytic bacteria isolated from Enhydra fluctuans Lour., a medicinal plant known for its antioxidant and antimicrobial properties. Fresh leaves were collected, surface-sterilized, and used to isolate bacterial endophytes.

Exploring the Neurobiological Mechanisms of Cancer Growth.

Emerging evidence reveals that interactions between the nervous system and tumor biology significantly influence cancer progression, metastasis, and therapeutic outcomes. This review elucidates the neurobiological mechanisms that underpin tumor development, highlighting the dynamic role of neural components within the tumor microenvironment (TME). Neural signals and structural adaptations in the TME stimulate tumorigenesis and enable cancer cell plasticity, mimicking neurodevelopmental processes.

Rapid cycling in late-onset bipolar affective disorder predominantly mania.

Bipolar affective disorder (BD) involves episodes of severe mood disturbance of depression and hypomania or mania and can result from the sensitization produced by repeated episodes. The authors present a case report assessed in the outpatient department of psychiatry of a tertiary care hospital in western Maharashtra. The patient was a 70-year-old female with late-onset rapid cycling bipolar affective disorder with predominantly hypomanic and manic episodes and co-morbidities of hypothyroidism, type II diabetes mellitus, and bullous pemphigoid.

Lateral Spread Response in Hemifacial Spasm: Physiological Mechanisms, Intraoperative Utility, and Prognostic Significance.

Facial nerve compression by blood vessels near the brainstem can cause hemifacial spasm (HFS). There are two treatment options for this condition: botulinum toxin and surgical microvascular decompression (MVD). During microvascular decompression, the facial nerve is separated from the offending vessel, and intraoperative neuromonitoring in these patients demonstrates abnormal muscle response (AMR), which is known as the lateral spread response (LSR).

Exploiting E3 ligases for lung cancer therapy: The promise of DCAF-PROTACs.

Lung cancer remains the leading cause of cancer-related mortality, underscoring the urgent need for novel therapeutic strategies. One emerging approach in drug development targets oncogenic proteins via the ubiquitin-proteasome system (UPS), specifically through proteolysis-targeting chimeras (PROTACs). Among the various E3 ligase complexes, the CRL4 complex-comprising DDB1 and CUL4-associated factors (DCAFs)-has garnered attention for its roles in cellular homeostasis, DNA repair, and oncogenesis.

Integrated AI and machine learning pipeline identifies novel WEE1 kinase inhibitors for targeted cancer therapy.

The dysregulation of the cell cycle in cancer underscores the therapeutic potential of targeting WEE1 kinase, a key regulator of the G2/M checkpoint. This study harnessed artificial intelligence (AI)-driven methodologies, particularly the MORLD platform, to identify novel WEE1 inhibitors. Starting with clinically validated WEE1 inhibitors as references, we generated 20,000 structurally diverse compounds optimized for binding affinity, synthetic accessibility, and drug-likeness.

Computer-aided drug design approach for alkaloids isolated from Miers as potential acetylcholinesterase inhibitors.

Considering the medicinal importance of alkaloids from Miers, five major compounds (stepharine, stepharanine, stepholidine, palmatine and tetrahydropalmatine) from the plant were analyzed for their acetylcholinesterase activity using molecular docking, molecular dynamics simulations and pharmacokinetics. As acetylcholinesterase has been significantly studied for their role in Alzheimer's disease, the enzyme from (PDB ID: 1QTI) was taken as a receptor protein. AutoDock Vina was used to study the docking affinities during the initial screening of compounds where, stepharine showed promising binding energy (-10.

Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer.

Fisetin, a flavonol belonging to the flavonoid subclass, is a ubiquitous dietary flavonoid present in fruits and vegetables, including fruit peels, and has proven potential for anticancer activity, especially for lung cancer - a leading cause of cancer-related deaths globally. The current paper provides the most detailed and elaborate list of the various roles of fisetin in experimentally induced lung cancer cells, and these roles include the promotion of apoptosis, inhibition of cell proliferation, migration, and invasion, as well as the regulation of autophagy. Among the molecular targets, some identified pathways, such as PI3K/Akt, MAPK, and NF-κB, that fisetin affects are crucial for tumor formation, so it can be considered a potential chemopreventive agent.

The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression.

Depression is a prevalent mood disorder with significant public health implications. Despite extensive research, its precise causes remain inadequately understood. Recently, interest has surged in the role of the gut microbiome and its metabolites in the pathophysiology of depression.

C2 Vertebra: An Enigma for Young Spine/Neurosurgeons.

 Instrumentation of C2 vertebra is considered the most difficult for young neurosurgeons and trainees due to its complex anatomical structures, variety of surgical approaches and techniques, and proximity to important neurovascular structures. Key points from a surgical perspective for midline posterior approach is described in the era of neuroradiological advancements.  Computed tomography angiographies (CTAs) of a total of 92 patients were evaluated with special attention to the key findings for insertion of screws for craniovertebral junction (CVJ) fixations.

Frontiers in Pulmonary Hypertension: A Comprehensive Insight of Etiological Advances.

Pulmonary hypertension (PH) is a severe, progressive disorder characterized by elevated pulmonary arterial pressure, leading to right ventricular failure and increased mortality. Despite advancements in management, the median survival for PH patients remains 5-7 years, with an inhospital mortality rate of approximately 6%. The core pathological feature of PH is pulmonary vascular remodeling (PVR), a multifactorial process involving endothelial dysfunction, inflammation, and aberrant immune responses.

Flavonoids and other constituents from Jacaranda mimosifolia: In vitro analysis, molecular docking, and molecular dynamic simulations of antioxidant and anti-inflammatory activities.

The investigation of the methanol extract of the flowers of Jacaranda mimosifolia led to the isolation and characterisation of fourteen secondary metabolites (1-14) by the means of chromatographic and spectroscopic analysis. These compounds include eight flavonoids sorted as two flavonols (1-2), three flavones (3, 7-8), and three isoflavones (4, 9-10), two glucoiridoids (5-6), and four triterpenoids sorted as one oleanane (11), one hopane (12), and two lupane (13-14). The in vitro antioxidant potential of all the isolated compounds was evaluated using the ABTS- and FRAP- methods, which demonstrated concentration-dependent activity.

Assessment of inhibitory potentiality of natural compounds against worrisome rice blast fungus.

Rice blast, a severe fungal disease, is a substantial threat to global food security, particularly in rice-oriented areas. The fungus is increasingly resistant and fast developing in nature. However, chemical fungicides are not only detrimental to the environment but eventually also lose their efficiency.

Comparative Neurodynamic Analysis of Spinal Energy Enhancement in Experienced Yoga Practitioners Using Various Breathing Techniques.

Introduction:  Yoga practices emphasize spinal energy's role in physical, mental, and spiritual well-being, suggesting specific techniques that can enhance energy flow along the spine. Modern research aims to validate these claims and understand the mechanisms behind these effects, potentially integrating them into contemporary healthcare models. This study explores the relationship between yoga breathing techniques, spinal energy dynamics, and health based on yoga philosophy and bioenergetics.

Comprehensive Analysis of Thyroidectomy-Related Complications: A Single-Center Perspective.

Background Thyroid surgeries have become so common that they are performed for both benign and malignant conditions of the thyroid. However, hypoparathyroidism and recurrent laryngeal nerve (RLN) injury may turn out to be a nightmare, complicating the surgical outcome. This study will, therefore, attempt to assess the complications related to different types of thyroid surgeries in order to identify the risk factors involved.

Potential MAO-B Inhibitors from Cissampelos Capensis L.f.: ADMET, Molecular Docking, Dynamics, and DFT Insights.

This study explores the therapeutic potential of three proaporphine alkaloids-cissamaline, cissamanine, and cissamdine, which were recently isolated from Cissampelos capensis L.f., against Parkinson's disease (PD).

Insights Into the Epidemiological, Clinical, Histopathological, and Dermoscopic Aspects of Chronic Plaque Psoriasis.

Background Psoriasis is a persistent inflammatory condition of the skin marked by clearly demarcated red plaques adorned with silvery scales. It impacts individuals across different age ranges and presents with unique clinical, histological, and dermoscopic characteristics. This research seeks to offer an extensive assessment of the demographic, clinical, histological, and dermoscopic attributes of chronic plaque psoriasis (CPP).