[Entrustable professional activities-A paradigm shift in the surgical training from quantity to quality].

Background: Since the 2020 revision of the medical training regulations surgical training in Germany has been based on the acquisition of knowledge (cognitive and methodological competence) as well as experience and skills (practical competence). As in previous training catalogues, minimum numbers are defined for essential operations; however, these operation catalogues do not reflect the actual surgical competence of residents.

Objective: This paper highlights the current challenges faced by prospective surgeons.

The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.

Macrovascular complications of diabetes mellitus (DM) are diseases of the peripheral and coronary arteries and the cerebrovascular system. Despite the availability of several conventional antidiabetic drugs, the macrovascular complications associated with DM remain a major health burden, partly because the focus of diabetes management has been glucocentric. Interestingly, phytochemicals, particularly flavonoids and other phenolics, were highly promising in the treatment of diabetes-associated macrovascular complications.

Indigenous African chickens (Gallus gallus domesticus) lack an anti-Trypanosoma factor and have a prospect for zoonotic transmission of African trypanosomiasis.

African trypanosomes evade host immune response through antigenic variation and utilize other immune modulatory mechanisms to survive in the immunologically hostile mammalian bloodstream. However, indigenous African chicken (Gallus gallus domesticus) exhibits lower susceptibility to trypanosomes, suggesting unique resistance mechanisms; but the exact factor(s) of resistance remains elusive. This study aims to elucidate the mechanisms underlying the observed resistance of indigenous African chickens to T.

A Retrospective Study of Foreign Body Ingestions and Outcomes Among the Pediatric Age Group in a Tertiary Care Hospital in Dubai, United Arab Emirates.

Background Foreign body ingestion (FBI) is a prevalent pediatric emergency, especially in toddlers. The clinical trajectory is significantly influenced by the type, size, and location of the object. Although many cases resolve without intervention, high-risk foreign bodies, including button batteries and magnets, present considerable health risks.

REaCT-5G: a randomized trial of bone pain with 5-day-filgrastim vs. pegfilgrastim for neutropenia in breast cancer.

Introduction: Granulocyte colony stimulating factors (G-CSF), including filgrastim and pegfilgrastim, are associated with bone pain, potentially impacting treatment adherence. This study hypothesized that a 5-day regimen of filgrastim (5-day-FIL) would result in less bone pain than single-dose pegfilgrastim (PEG) in patients receiving chemotherapy for early breast cancer.

Methods: In this multicenter, open-label, randomized controlled trial, patients requiring prophylactic G-CSF during chemotherapy were randomized 1:1 to receive either 5-day FIL or PEG.

Adult-Onset Still's Disease in a 49-Year-Old Female in the UAE: A Case Report and Literature Review.

Adult-onset Still's disease (AOSD) is a rare autoinflammatory disorder characterized by high spiking fevers, salmon-colored rash, arthritis, and hyperferritinemia. It often mimics infections or autoimmune conditions, leading to diagnostic delays. We report a case of a 49-year-old female who presented with fever, fatigue, arthralgia, evanescent rash, and elevated inflammatory markers.

Technological Advances in Pre-Operative Planning.

Surgery remains a healthcare intervention with significant risks for patients. Novel technologies can now enhance the peri-operative workflow, with artificial intelligence (AI) and extended reality (XR) to assist with pre-operative planning. This review focuses on innovation in AI, XR and imaging for hepato-biliary surgery planning.

Receipt of adequate antenatal care and associated factors among women delivering in public hospitals, Afar region, Ethiopia.

Adequate antenatal care (ANC) is crucial for improving pregnancy outcomes through preventive and promotive interventions. Despite WHO standards for regular check-ups, screenings, and counseling, compliance in Ethiopia's pastoral areas, particularly Afar, is underexplored. This study assessed adequate ANC receipt and its associated factors among 704 women who delivered in public hospitals in Afar, Northeast Ethiopia.

Three-Dimensional Choroidal Vessel Analysis in Asymmetric Bilateral Age-Related Macular Degeneration: A Comparison of Active Neovascular AMD and Dry AMD Fellow Eyes.

Purpose: To assess choroidal vasculature in bilateral age-related macular degeneration (AMD) patients, with neovascular AMD in one eye and dry AMD in the other, using an innovative three-dimensional (3D) algorithm.

Methods: This retrospective cross-sectional study included 30 patients with asymmetric bilateral AMD. All patients underwent clinical exams and swept-source optical coherence tomography using PlexElite-9000 (Carl Zeiss Meditec, Dublin, CA) scans centered on the fovea.

The Role of Sleep Disturbances in Alzheimer's Disease Progression: A Systematic Review.

Sleep disturbances are increasingly recognized as potential contributors to Alzheimer's disease (AD) progression, but their exact role remains debated. This systematic review aims to synthesize existing evidence on the association between sleep disturbances, particularly disruptions in sleep architecture and obstructive sleep apnea (OSA), and cognitive decline or AD biomarkers, while exploring underlying mechanisms. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 14 studies were selected from a comprehensive search of PubMed, Excerpta Medica Database (Embase), Psychological Information Database (PsycINFO), and Web of Science.

"We Are Our Own Worst Enemies": Workplace Bullying Among Nurses and Its Implications on Healthcare Workers and Job Performance: A Multi-Facility Study in the Tamale Metropolis.

Background: Workplace bullying is an important issue confronting the nursing profession, with victims described as being part of an oppressed group. The number of attacks and acts of violence that staff direct at each other in the workplace is alarmingly high and cannot be ignored.

Aim: This study assessed the prevalence and impact of workplace bullying of nurses by other nurses among those working in three major hospitals in the Tamale Metropolis, Ghana.

Efficacy and safety of moxidectin-albendazole combination therapy for Trichuris trichiura infections in school-aged children: a double-blind, randomised, controlled, superiority trial.

Background: Infection with the soil-transmitted helminth Trichuris trichiura affects up to 300 million people globally, with children in rural areas in less economically developed countries being most at risk. If untreated, infection compromises physical and cognitive development and leads to long-lasting morbidity. We assessed whether moxidectin co-administered with albendazole is superior to the recommended albendazole monotherapy in treating trichuriasis in school-aged children.

Allergen to asset: Pollen-based drug delivery systems.

The rising demand for therapeutics, driven by aging populations and chronic diseases, challenges the pharmaceutical manufacturing of sustainable drug delivery systems. While development of microcarriers from natural sources such as plant or animal-sourced polymers and lipids show promise, the resource-intensive and complex processes involved limits their translatability and access. In this review, we discuss briefly the existing microcarriers fabricated from natural polymers and transition to recent efforts that have been devoted to exemplify pollen, traditionally regarded as an allergen, exhibits qualities that fit the criteria of a desirable microcarrier, and can be exploited to be valuable drug delivery assets with potential of encapsulating a wide spectrum of cargo and targeted conveyance.

Association Between Metabolic Syndrome and Subclinical Hypothyroidism: A Systematic Review.

Metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent endocrine-metabolic disorders with significant cardiovascular implications. Emerging evidence suggests a bidirectional relationship between these conditions, but findings remain inconsistent across populations. This systematic review synthesizes existing literature to evaluate the association between SCH and MetS, focusing on prevalence, demographic variations, and mechanistic links.

Virtual screening and molecular dynamic simulations of dissimilatory sulfite reductase inhibitors for the control of sulphate reducing bacteria.

Unlabelled: Dissimilatory sulfite reductase (DSR) plays a crucial role in the metabolism of sulfate-reducing bacteria (SRB), which contribute to environmental hazards such as biocorrosion and sulfide pollution. The search for effective DSR inhibitors has been challenging due to the difficulty in culturing strict anaerobes. In this study, we employed molecular docking and 100 ns molecular dynamics (MD) simulations to screen 248 microbially-derived compounds for their potential as DSR inhibitors.

Predictors of treatment failure and outcome assessment of extracorporeal shock wave lithotripsy with the Dornier Compact Delta® III Pro: experience from the first 1000 treatments.

Background: The Dornier Compact Delta® III Pro is a next-generation extracorporeal shock wave lithotripter featuring flat-panel detector technology for enhanced imaging and a compact modular design. This study evaluates treatment outcomes and predictors of failure for this system, representing the first published clinical experience.

Methods: We retrospectively analyzed the first 1,000 consecutive patients treated with the Dornier Compact Delta® III Pro for renal or ureteric stones between May 2022 and November 2023 at a secondary hospital.

Three-Dimensional Choroidal Contour Mapping in Healthy and Diseased Eyes.

Purpose: Quantitative evaluation of choroidal curvature including choroidal inner boundary (CIB) and choroidal outer boundary (COB) and report a comparison between healthy and diseased eyes.

Methods: This retrospective study was conducted on 97 eyes of 97 patients. Eyes were divided into three groups: central serous chorioretinopathy (CSCR), dry age-related macular degeneration (AMD), and healthy eyes.

Impact of pubertal imidacloprid exposure on the genital tract of Japanese quail (Coturnix Coturnix japonica): Histomorphometric and ultrastructural study.

Background: The effects of exposure to the neonicotinoid pesticide, imidacloprid (IMI), on the histopathology and ultrastructure of the genital tracts of pubertal male and female Japanese quails (Coturnix Coturnix japonica) were investigated.

Methods: Pubertal quail (n = 28), commencing at 5 weeks post-hatching, were orally gavaged with 1.55 (low), 3.

Utilizing silica-rich waste material for enhancing the properties of concrete and its environmental assessment.

Some of the industrial solid waste materials, despite having sizeable quantities of silica and alumina, do not meet the requirements of a supplementary cementitious material (SCM) as per ASTM C618. Conversely, these materials may well be classified as alternative supplementary cementitious materials (ASCM) in accordance with ASTM C1709. Even though they have the potential of enhancing the properties of concrete and promoting sustainability, these materials are often underutilized in construction.

Advanced Hybrid Closed-Loop Insulin Delivery Is Associated With Improved Glycemic Indicators and Normalization of Small Nerve Fibre Structure in Adults With Type 1 Diabetes.

Background: Hyperglycemia is a major driver of diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM). Advanced hybrid closed-loop (AHCL) technologies improve glycemic control and reduce glycemic variability and may improve DPN.

Methods: Patients with T1DM treated for 9.

From knowledge to impact: revolutionizing nursing practices in biomedical waste management for sustainable healthcare excellence.

Background: Effective biomedical waste management is essential for minimizing environmental contamination and safeguarding public health. Nurses play a pivotal role in this process, yet their competence often requires enhancement, particularly in resource-limited settings.

Aim: This study evaluates the effectiveness of an educational program in improving nursing competence in biomedical waste management at El-Minia University Hospitals.

Enhanced image hash using cellular automata with sponge construction and elliptic curve cryptography for secure image transaction.

With the rapid development of digital communications, sensitive digital storage security, especially that of images, remains a significant challenge. Most of the existing hash algorithms cannot meet the requirements of security, efficiency, and adaptability in cryptographic applications based on an image. We will fill this critical gap by proposing a new hybrid hash algorithm integrating three powerful cryptographic concepts: Cellular Automata (CA), sponge functions, and Elliptic Curve Cryptography (ECC).

Radiomics-Based OCT Analysis of Choroid Reveals Biomarkers of Central Serous Chorioretinopathy.

Purpose: Biomarkers from choroidal imaging can enhance clinical decision-making for chorioretinal disease; however, identification of biomarkers is labor-intensive and limited by human intuition. Here we apply radiomics feature extraction to choroid imaging from swept-source optical coherence tomography (SS-OCT) to automatically identify biomarkers that distinguish healthy, central serous chorioretinopathy (CSCR), and unaffected fellow eyes.

Methods: Radiomics features were extracted from SS-OCT images from healthy (n = 30), CSCR (n = 39), and unaffected fellow eyes (n = 20), with a total of 44,500 single-cross sectional horizontal images and 8900 en face images.

Unravelling cyberbullying among Egyptian adolescents: the protective influence of self-control and moral identity with gender and socioeconomic dynamics.

Background: Cyberbullying presents a significant challenge for adolescents, leading to severe psychological and social consequences. This study explores the relationships between cyberbullying, self-control, and moral identity among Egyptian school students, considering gender and socioeconomic factors from a nursing perspective.

Methods: A cross-sectional, descriptive correlational study was conducted among 304 preparatory and secondary school students aged 12-20 years in Egypt.

The antidiabetic properties of lignans: a comprehensive review.

Background: Diabetes mellitus (DM) is a chronic metabolic disease with a high global prevalence. Lignans, a class of plant natural compounds found in commonly consumed foods, are well-tolerated by humans and have demonstrated promising potential in the management of DM. Consumption of lignan-rich foods has been associated with improved overall health and quality of life.