GSK-3α regulates miRNAs associated with transcriptional and metabolic processes in human cardiomyocytes under hypoxia.

Glycogen synthase kinase-3α (GSK-3α) is a multifunctional kinase plays roles in the pathogenesis of various cardiac diseases, including ischemia and pressure overload and ischemia-reperfusion-induced injury. It regulates key cellular processes such as cardiac cell proliferation, apoptosis, metabolism, and inflammation. However, its role in regulating cardiac microRNAs (miRNAs) remains unknown.

The Association between β-Thalassemia Major (β-TM) and Cardiac Complications: Recent Insights.

β-thalassemia Major (β-TM) is a severe hereditary disorder characterized by insufficient synthesis of β-globin chains, resulting in chronic anemia and lifelong dependence on regular blood transfusions. Despite advancements in therapeutic modalities, cardiac complications, including atrial fibrillation, cardiomyopathy, and pulmonary hypertension, continue to be significant contributors to morbidity and mortality among β-TM patients. These persistent cardiovascular risks underscore the urgent need for early, accurate detection and the implementation of personalized assessment strategies to improve patient outcomes.

Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer.

Recent advances in single-cell technologies have uncovered significant cellular diversity in tumors, influencing cancer progression and treatment outcomes. The Hippo pathway controls cell proliferation through its downstream effectors: yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ). Our analysis of human lung adenocarcinoma and murine models revealed that cancer cells display heterogeneous YAP/TAZ activation levels within tumors.

Environmental risk assessment of the Nile Delta, Egypt, based on radar interferometry, altimetry, and geodetic measurements.

Egypt is confronted with a number of hazardous environmental incidents, mainly sea level rise (SLR) and land subsidence. The Nile Delta is a low-relief surface that is particularly vulnerable to flooding and SLR, making it important to study inundation scenarios for the region. Potential social and economic consequences of this anticipated sea encroachment were projected utilizing (1) crustal deformation calculations derived from the time series analysis using the Persistent Scatterer Interferometry (PSI) technique based on Least Squares Estimation.

Prevalence, Knowledge, and Attitudes of Energy Drink Consumption Among University Students in the United Arab Emirates: A Cross-Sectional Study.

Background The consumption of energy drinks (EDs) among university students in the United Arab Emirates (UAE) has not been extensively studied. Therefore, this cross-sectional study aimed to investigate the prevalence, attitudes, and knowledge regarding EDs among university students in the UAE. Objective The primary objective of this study was to evaluate the prevalence, attitudes, motives, consumption patterns, and practices toward ED consumption among university students in the UAE.

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.

Importance: Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving its distinct burden estimates obscure.

Objective: To estimate the worldwide burden of SAH.

Efficacy of Cerebroplacental Doppler Ratio in Predicting Adverse Fetal Outcomes in Cases of Fetal Growth Restriction Multicenter Study.

Introduction: Fetal growth restriction (FGR) is a significant cause of perinatal morbidity and mortality. Differentiating FGR from small-for-gestational-age fetuses is critical for risk assessment. This study investigates the cerebroplacental ratio (CPR) as a noninvasive predictor of adverse fetal outcomes, particularly neonatal intensive care unit (NICU) admissions, intrauterine fetal death (IUFD), and birth weight variability.

Effect of a self-ligating bracket system combined with corticision on the rate of orthodontic tooth movement: A controlled clinical trial.

Background: The self-ligating bracket system and corticision are two methods for acceleration of orthodontic tooth movement (OTM).

Objectives: The current study aimed to assess the effect of a self-ligating bracket system combined with corticision on the rate of OTM.

Patients And Methods: The present study was conducted on 16 female patients divided into two groups: an experimental group of eight patients treated by self-ligating bracket systems used as fixed orthodontic appliances combined with a corticision as a minimally invasive surgical technique for accelerating OTM, and a control group of eight patients treated only by self-ligating bracket systems used as fixed orthodontic appliances.

The prevalence of metabolic syndrome in patients with non-alcoholic fatty liver disease in primary care clinics at King Saud University Medical City, Riyadh, Saudi Arabia.

Background: Metabolic syndrome is present in a subset of individuals harboring a constellation of metabolic risk factors that heightens their likelihood of developing coronary artery disease. Non-alcoholic fatty liver disease (NAFLD) manifests through the incremental accumulation of fat within liver cells in the absence of secondary causes. NAFLD has long been recognized as the hepatic manifestation of metabolic syndrome.

Improving Barhi date shelf life with cellulose nanocrystals/cinnamon oil Pickering emulsion incorporated into sodium alginate-based films.

This study developed sodium alginate-based films enhanced with cinnamon essential oil (CNEO) Pickering emulsions stabilized by cellulose nanocrystals (CNC) at concentrations of 0.5 %, 1.0 %, and 2.

The Stmn1-lineage contributes to acinar regeneration but not to neoplasia upon oncogenic Kras expression.

Background & Aims: The exocrine pancreas has a limited regenerative capacity, but to what extent all acinar cells are involved in this process is unclear. Nevertheless, the heterogenous nature of acinar cells suggests that cells exhibiting higher plasticity might play a more prominent role in acinar regeneration. In that regard, -expressing acinar cells have been identified as potential facultative progenitor-like cells in the adult pancreas.

The use of the white biotechnology toolkit to edit natural purines for studying their anticancer activity via mTOR pathway.

Purine alkaloids were proven to have significant cytotoxic activity against different cancer cell lines via modulating several cellular pathways, leading to inhibition of cell proliferation and increasing cell death. The search for new potential cytotoxic compounds produced by natural eco-friendly means is of great importance. The microbial transformation of natural purine alkaloids, caffeine (Cf), theophylline (Tp), theobromine (Tb), and theacrine (Tc) via filamentous fungi was explored using Aspergillus versicolor (AUMC 4807), Aspergillus niger (NRRL 328), Cunninghamella echinulata (ATCC 1382), and Penicillium chrysogeneum (ATCC 9480).

Analysis of sensorineural hearing loss and its relation to Optical Coherence Tomography Angiography findings in Behcet's disease.

Objectives: We aimed to analyze auditory involvement in patients with Behcet's disease and its association with Optical Coherence Tomography Angiography findings and disease manifestations.

Methods: This study included 54 eyes and 68 ears of 34 adults with Behcet's disease in comparison to 30 eyes and 60 ears of healthy controls. Clinical, laboratory and ophthalmological evaluation including Optical Coherence Tomography Angiography was done.

Microencapsulation of antioxidant phenolics from tamarind seed peels using chia gum and maltodextrin.

Tamarindus indica seeds/seed peels (TSP) are the main waste products from the tamarind industry and contain valuable bioactive antioxidant-phenolic compounds that promote human health; however, their application is limited due to their instability and poor solubility. Encapsulation is becoming more important in several industries due to its potential for preserving and delivering valuable and delicate bioactive compounds. This study targets the microencapsulation of TSP-phenolic compounds for incorporation into functional food formulations.

Barriers and facilitators of school-based obesity prevention interventions: a qualitative study from the perspectives of primary school headteachers.

Background: Childhood obesity is a growing global health issue. The World Health Organization identifies obesity as a significant risk factor for Non-Communicable Diseases and considers it a pandemic. This study aimed to investigate headteachers' perspectives and practices concerning childhood obesity prevention interventions in primary schools highlighting the barriers and facilitators for those interventions.

Biochemical properties of immobilized horseradish peroxidase on ceramic and its application in removal of azo dye.

In the current work, electrostatic interactions were used to immobilize the horseradish peroxidase (HRP) onto five types of ceramic materials (C) with different concentrations of oxidized metals (C1-C5). The highest immobilization efficiency (70 and 77%) was detected at 6 mg C3 and 18 enzyme units. Scanning Electron Microscope (SEM), Energy Dispersive X-ray (EDX) and Fourier Transform Infrared (FTIR) analysis of C3-HRP confirmed the immobilization of the enzyme.

Enhanced Olivine Reactivity in Wet Supercritical CO for Engineered Mineral Carbon Sequestration.

The success of CO mineralization as a potential solution for reducing carbon emissions hinges on understanding chemical interactions between basaltic minerals and CO-charged fluids. This study provides a detailed analysis of olivine dissolution in CO-water mixtures at 90 and 150 °C, 2-9 MPa, and for 8 and 24 h, in both water- and CO-dominant conditions. By using olivine crystal sections instead of powders, surface agitation is prevented, closing the gap between laboratory studies and natural settings.

ACE Inhibitors and Angiotensin Receptor Blockers for the Primary and Secondary Prevention of Cardiovascular Outcomes: Recommendations from the 2024 Egyptian Cardiology Expert Consensus in Collaboration with the CVREP Foundation.

Introduction: The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in regulating blood pressure (BP), with dysregulation of RAAS resulting in hypertension and potentially heart failure (HF), myocardial infarction (MI), cardio-renal syndrome, and stroke. RAAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs), have advantages beyond BP control. However, differences between these two drug classes need to be considered when choosing a therapy for preventing cardiovascular events.

Draft genome sequence analysis of multidrug-resistant subsp. serovar Mbandaka harboring colistin resistance gene - isolated from foals in Kentucky, USA.

Horses play a significant role in the direct or indirect transmission of to humans. Here, we report the draft genomes of multidrug-resistant subsp. serovar Mbandaka YAH-F68 isolated from foals in Kentucky, USA belonging to sequence type 413 and harboring the mobile colistin resistance gene -.

Thermal, mechanical, and electrical properties of Si-stacked nanosheet transistors using machine learning interatomic potentials.

Thermal and mechanical properties play a key role in optimizing the performance of nanoelectronic devices. In this study, the lattice thermal conductivity (κL) and elastic constants of Si nanosheets at different sheet thicknesses were determined using recently developed machine learning interatomic potentials (MLIPs). A Si nanosheet with a minimum thickness of 10 atomic layers was used for model training to predict the properties of sheets with greater thicknesses.

Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations.

In this work, additional effort was applied to design new BIBR1532-based analogues with potential inhibitory activity against telomerase and acting as multitarget antitumor candidates to overcome the resistance problem. Therefore, novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates (4a-n) were synthesized. Applying the lead optimization strategy of the previously designed compound 8e; compound 4l showed an improved telomerase inhibition of 64.

The efficacy of diazepam administration during embryo transfer: a retrospective multicenter cohort study on reproductive outcomes.

Purpose: This retrospective multicenter cohort study aimed to investigate the impact of diazepam administration during embryo transfer on reproductive outcomes, focusing primarily on the live birth rate. Secondary outcomes included the positive beta-hCG rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate, and preterm birth rate.

Methods: Data from 5607 embryo transfers, encompassing 465 cases with diazepam administration, were retrospectively analyzed.