Publications by authors named "Jorge R Arbujas"
Background & Aims: The exocrine pancreas has a limited regenerative capacity, but to what extent all acinar cells are involved in this process is unclear. Nevertheless, the heterogenous nature of acinar cells suggests that cells exhibiting higher plasticity might play a more prominent role in acinar regeneration. In that regard, -expressing acinar cells have been identified as potential facultative progenitor-like cells in the adult pancreas.
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- - A lack of functional β-cells leads to diabetes, and there isn't an effective cell replacement therapy available yet.
- - Researchers found that inhibiting focal adhesion kinase in adult mice enables certain acinar cells to transform into insulin-producing β-like cells.
- - This transformation helps restore some β-cell mass and improves glucose control in diabetic mice, suggesting a potential new approach for diabetes treatment.