The Stmn1-lineage contributes to acinar regeneration but not to neoplasia upon oncogenic Kras expression.

Background & Aims: The exocrine pancreas has a limited regenerative capacity, but to what extent all acinar cells are involved in this process is unclear. Nevertheless, the heterogenous nature of acinar cells suggests that cells exhibiting higher plasticity might play a more prominent role in acinar regeneration. In that regard, -expressing acinar cells have been identified as potential facultative progenitor-like cells in the adult pancreas.