Design, Synthesis, Antimicrobial and Antitumor Activities of Benzo[f]chromene Derivatives: DFT and Molecular Docking.

Introduction: Benzochromenes are heterocyclic compounds of growing interest in medicinal chemistry due to their diverse biological activities, including antioxidant, anticancer, and antimicrobial properties.

Methods: A one-pot, three-component synthesis was employed to prepare benzochromene derivatives (4a-f) using 2-naphthol or its derivatives, active methylene compounds, and 2-methoxybenzaldehyde in ethanol with piperidine as a catalyst. The compounds were evaluated for their anticancer activity against MCF-7, HepG-2, and HCT-116 cell lines, as well as for their antimicrobial activity through molecular docking studies targeting cancerrelated and microbial proteins.

Comparative analysis of third-generation dual-energy CT and IVUS for in-stent restenosis detection.

Purpose: Prior studies have assessed in-stent diameter restenosis (ISDR) in coronary arteries using 64-slice multidetector computed tomography coronary angiography (MDCT-CA) compared to invasive coronary angiography (ICA), which is the gold standard. This study aimed to compare the diagnostic accuracy of monoenergetic reconstruction using third-generation dual-source dual-energy CT (DSDECT) to that of ICA reconstruction via adjunctive intravascular ultrasonography (IVUS) for evaluating the ISDR.

Methods: A total of 95 patients with previously stented coronary arteries (involving 110 stents) underwent DSDECT followed by ICA and IVUS within a 24-h timeframe.

Association between obesity and cardiac conduction defects.

Background: Literature on the association between high body mass index (BMI) and cardiac conduction defects (CCD) is scarce.

Methods: The cross-sectional association between obesity and CCD was examined in 455,790 participants (56.1 years; 55.

Assisted implant stabilization using a modified microplate fixation technique.

Objectives: In many clinical cases, the surgical defect around the osteotomy does not grant sufficient stability which may compromise the inserted dental implant. Using a fixation microplate may solve this issue by improving the stability of the inserted implant. This study aimed to evaluate assisted implant stability using microplate fixation in compromised bone defects.

Development, characterization, and optimization of folate-chitosan surface-modified PLGA-decorated mesoporous silica nanoparticles for effective delivery of leflunomide for the management of rheumatoid arthritis.

Folate-chitosan surface modification of PLGA-decorated mesoporous silica nanoparticles (FC-PLGA-MSNs) was implemented to improve the delivery of leflunomide (LEF) for the management of rheumatoid arthritis (RA). These nanoparticles were designed to address LEF's poor bioavailability and side effects, such as hepatotoxicity and gastrointestinal distress, by enhancing oral delivery and targetability to inflamed joints. Various MSNs were prepared and optimized with different levels of pH and silica precursor (TEOS).

Exploring Optimal Cardiac Electronic Implantable Devices Programming: Reducing Non-Actionable Alerts and Assessing Clinical Outcomes.

Background: The rapid evolution of cardiac implantable electronic devices (CIEDs) has increased remote transmission data, leading to excessive non-actionable alerts (NAA) and alert fatigue.

Objective: Optimize alert parameters to minimize NAA and evaluate the impact on clinical outcomes.

Methods: We included 536 participants (mean age 75 (15) years, 60.

Harnessing Q-tube pressure reactor for the synthesis of novel pyrano[2,3-]thiazole derivatives utilizing Mg-Al-layered double hydroxide catalyst: catalysis meets sustainability.

This research introduces Mg-Al-layered double hydroxide (MgAl-LDH) as an innovative sustainable nanocatalyst for the synthesis of pyrano[2,3-]thiazole derivatives, utilizing Q-tube pressure reactor technology to improve efficiency and minimize environmental effects. The MgAl-LDH catalyst and its calcined derivatives (250 °C and 450 °C) were meticulously characterized using FT-IR, XRD, and BET analysis, demonstrating that the uncalcined LDH possessed a 1.5-fold greater surface area (78 m g) and enhanced catalytic activity relative to its thermally treated variants.

The long antisense non-coding RNA HOXA transcript at the distal tip (LncRNA HOTTIP) in health and disease: a comprehensive review and in silico analysis.

Since lncRNAs are RNA transcripts with more than 200 nucleotides that do not encode proteins, they are functional units themselves. It has been demonstrated that they participate in a variety of biological processes. One particular long noncoding RNA, known as HOXA transcript at the distal tip (HOTTIP), is encoded from a genomic region in the 5' tip of the HOXA locus.

Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer.

Background: Nutritional impairment is common among older adults with advanced cancer. The association between baseline nutritional impairment and the trajectory of quality of life (QOL) and psychological health among patients receiving palliative cancer treatment is not known.

Methods: We performed a secondary analysis of a nationwide clinical trial (NCT02107443; PI: Mohile, UG1CA189961).

LSPR-Driven Dual-Mode Urea Sensor for Milk Adulteration Detection Using Gold Nanobipyramids and Upconversion Nanoparticles.

Ensuring food quality and safety is crucial, as the consumption of contaminated or substandard food poses serious risks to public health and imposes a substantial economic burden. Among various food safety concerns, milk adulteration with urea has emerged as a significant issue. This study presents a highly sensitive dual-mode colorimetric and fluorometric urea sensor for milk adulteration detection, utilizing enzymatic hydrolysis with Fenton-mediated plasmonic etching.

Kalimah norms: Ratings for 2,467 modern standard Arabic words on two scales.

Crowdsourced normative ratings have benefited psycholinguistic research considerably. Yet, Modern Standard Arabic (MSA) has scarce word norms. To address this scarcity, the current study developed and validated the Kalimah norms in two experiments.

Unlocking molecular secrets: The role of miRNAs in Parkinson's disease dynamics.

Parkinson's disease (PD) is a devastating neurological age-related ailment that causes dysfunction in the motor system, leading to symptoms such as involuntary shaking at rest, muscle stiffness with jerky movements, difficulty with walking, sluggish movement, and issues in sustaining posture. A state of insufficient dopamine in the striatum can be linked to a significant decrease in dopaminergic neurons within the substantia nigra pars compacta. Likewise, the formation of Lewy bodies is a distinctive pathogenic feature of PD.

Fatigue, physical function, and the context of social vulnerability for older adults with cancer.

Introduction: Older adults with cancer-related fatigue often experience impairments in their physical function. Social determinants of health (SDOH) at the individual and community level may mean some patients have fewer resources to deal with fatigue and are at greater risk for decline in physical function.

Materials And Methods: We analyzed patients age ≥ 70 with advanced cancer and ≥ 1 aging-related impairment who were starting new treatment regimens with a high risk of toxicity in a nationwide cluster-randomized clinical trial (NCT02054741, UG1CA189961).

Effect of Different Veneering Techniques on Mechanical Properties and Translucency of Zirconia Framework-veneer Ceramic Crowns.

Aim: The aim of this study is to assess the effect of veneering techniques on bond strength, fracture resistance (FR), and translucency of zirconia framework-veneer ceramic crowns.

Materials And Methods: Four commercially available glass ceramic materials were used in this study: IPS e.max CAD (Ivoclar Vivadent), IPS e.

Drug Reaction With Eosinophilia and Systemic Symptoms and Severe Drug-Induced Liver Injury After Off-Label Zonisamide Use for Weight Loss.

Drug-related eosinophilia with systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction causing rash and systemic symptoms. Associated liver injury ranges from abnormal laboratory results to liver failure. We report a case of zonisamide-induced DRESS with severe liver injury, characterized by vanishing bile duct syndrome.

Efficacy of Anlotinib Plus Docetaxel in Advanced NSCLC Previously Treated with Platinum-Based Chemotherapy: A Systematic Review and Meta-Analysis.

: Anlotinib is a novel oral antiangiogenic tyrosine kinase inhibitor (TKI) approved as a third-line treatment for advanced non-small-cell lung cancer (NSCLC). However, its efficacy in combination with docetaxel remains incompletely understood. Given the need for effective second-line therapies after platinum-based chemotherapy, this systematic review aims to evaluate the therapeutic potential of anlotinib plus docetaxel in advanced NSCLC.

Serum α-Synuclein in Pediatric Refractory Epilepsy: Correlation with Diagnosis and Clinical Severity.

Epilepsy is a common neurological disrupt that involves recurring seizures. α-Synuclein (α-Syn), one of the most abundant proteins in the nervous system, is implicated in both neurodegenerative conditions and epilepsy. This study aimed to assess serum α-Syn levels in children with drug-resistant epilepsy (DRE) and explore the relationship with diagnosis and clinical severity.

Microstructural modeling of the fragmentation of ordinary chondrites.

The fracture behavior of rocks on asteroids offers insights into the evolution and dynamics of their boulders and regolith while providing critical data for developing hazard mitigation strategies. Information about the mechanical properties of asteroidal boulders primarily comes from laboratory studies of meteorites. This study examines the fracture mechanics of an ordinary chondrite (OC) using an innovative combination of experimental and computational methods to create models for the fragmentation processes of asteroidal materials.

Boosting Zinc-Ion Hybrid Supercapacitor Performance with Basil-Derived Activated Carbon: Impact of Substrates and Mass Loading on Electrochemical Efficiency.

This study explores the use of basil-derived activated carbon (BC) as an electrode material for zinc-ion hybrid supercapacitors (ZIHSCs) in a coin cell configuration. BC is synthesized through straightforward pyrolysis and deposited on various conductive substrates, including graphite foil (Gr), carbon cloth (CC), titanium foil (Ti), copper foil (Cu), and nickel foam (Ni). Among these, graphite foil (BC-Gr) demonstrates the most favorable electrochemical performance.

Trueness and depth discrepancy of post-space scans using an intraoral scanner: influence of preparation dimensions: an in vitro study.

Background: Intraoral scanning of post spaces offers a potential alternative to conventional impressions, but its effectiveness depends on overcoming limitations influenced by post space dimensions.

Aim Of The Study: This study aimed to evaluate the trueness and depth discrepancy percentage of scanned post spaces with different dimensions using an intraoral scanner.

Materials And Methods: Twenty single-rooted human maxillary canines were endodontically treated.

Performance of AI-Chatbots to Common Temporomandibular Joint Disorders (TMDs) Patient Queries: Accuracy, Completeness, Reliability and Readability.

TMDs are a common group of conditions affecting the temporomandibular joint (TMJ) often resulting from factors like injury, stress or teeth grinding. This study aimed to evaluate the accuracy, completeness, reliability and readability of the responses generated by ChatGPT-3.5, -4o and Google Gemini to TMD-related inquiries.

Few-mode energy-managed soliton fiber laser.

We present an all-anomalous mode-locked laser architecture combining a few-mode gain fiber with single-mode passive fibers. This hybrid fiber laser generates high-energy pulses whose features are controlled by an intracavity spectral filter. Using a 1.

Ecofriendly Sunlight-Mediated Nontoxic Bimetallic Nanoparticles: Synthesis, Reusable Catalytic Membrane, and Biosensor Applications.

Bimetallic nanoparticles (BMNPs) combine the desirable properties of two distinct metals that outperform conventional monometallic nanoparticles (NPs). This work presents a novel ecofriendly silver-copper (Ag-Cu) BMNPs synthesis using sunlight as a green reducing agent, enableing rapid Ag-Cu BMNPs formation at room temperature within 10 min. This method exploiting the facile reduction of Ag⁺ to Ag⁰, which subsequently mediates the reduction of Cu⁺ to Cu⁰ via water radiolysis-generated species.