Response to [Comment on is clozapine use a risk of hematological malignancies? Insights from a meta-analysis "Clozapine and Malignancy Risk"].

This article relates to Comment on: is clozapine use a risk of hematological malignancies? Insights from a meta-analysis "Clozapine and Malignancy Risk".

Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis.

Background: Migraine is a disabling disorder characterized by recurrent severe headache attacks. Non-invasive neuromodulation can be employed in the prevention and/or acute treatment of migraine. Remote electrical neuromodulation (REN), a type of non-invasive neuromodulation, is an effective and safe at-home treatment for migraine.

Efficacy and Safety of Glibenclamide on Functional Outcomes and Cerebral Edema Following Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: This systematic review and meta-analysis aims to evaluate the clinical and radiological outcomes of glibenclamide versus control in acute stroke.

Methods: In accordance with PRISMA guidelines, a comprehensive literature search was conducted to identify relevant studies up to January 15, 2025. Efficacy outcomes included modified Rankin Scale (mRS) score at 3 and 6 months, Barthel Index (BI), midline shift (MLS) at 72-96 hours, serum MMP-9 levels and decompressive craniectomy.

The efficacy and safety of coronary sinus reducer in refractory angina: a systematic review and meta-analysis.

Background: Refractory angina is a challenging medical disorder associated with continuous anginal symptoms that do not respond to medical treatments or revascularization interventions. Coronary sinus reducer (CSR) has been introduced as a promising treatment option for patients with refractory angina. However, the avaliable evidence regarding the exact role of CSR in managing refractory angina is still inconclusive and limited by several factors, such as small sample size studies, and short follow up periods.

Robotic assisted vs. open ureteral reimplantation in adults: a systematic review and meta-analysis.

Ureteral reimplantation is a critical surgical procedure for restoring ureteral function, traditionally performed using open ureteral reimplantation (OUR). However, robotic-assisted ureteral reimplantation (RUR) has emerged as a minimally invasive alternative with potential perioperative advantages. To systematically compare the postoperative outcomes and efficacy of RUR and OUR in ureteral reimplantation in adults through a meta-analysis of existing studies.

The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.

Sleep disturbances in Parkinson's disease (PD) reduce quality of life. Melatonin, a sleep-wake hormone, shows treatment potential. However, its efficacy in PD remains unclear due to inconclusive findings across studies, warranting a systematic review to synthesise the available evidence.

Dorsal- vs ventral-onlay buccal mucosal graft urethroplasty for urethral strictures: a meta-analysis.

Objective: To compare ventral- and dorsal-onlay buccal mucosal graft (BMG) urethroplasty in patients with urethral stricture, as the optimal placement of BMG in urethroplasty for bulbar urethral strictures remains debated.

Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library. Studies comparing dorsal- and ventral-onlay BMG urethroplasty were analysed.

Efficacy and safety of ondansetron in schizophrenia: A systematic review and meta-analysis of randomized controlled trials.

Purpose: It has been shown that 5-hydroxytryptamine3 (5-HT3) receptors are involved in the pathogenesis of schizophrenia. This systematic review and meta-analysis of randomized clinical trials (RCTs) evaluates the efficacy and safety of ondansetron, a potent 5-HT3 receptor antagonist, as adjunctive treatment for the management of schizophrenia, especially the negative symptoms.

Methods: A comprehensive search of electronic databases, including PubMed, Scopus, Cochrane, and Web of Science, was performed in October 2024.

Insights on the Association between Antimicrobial Use and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.

Introduction: Gut dysbiosis is one of the environmental factors that might contribute to the development of Parkinson's disease (PD). The potential impact of antimicrobial agents on PD risk, particularly through dysbiosis and neuroinflammation, is an area of ongoing investigation, though findings remain inconsistent.

Methods: This systematic review and meta-analysis aimed to assess the relationship between antimicrobial use and PD risk.

Efficacy and safety of GLP-1 agonists in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.

Recent trends suggest exploring the repurposing of different drugs for Parkinson's disease patients (PD). One of these drugs is Glucagon-like peptide-1 (GLP-1), a medication used to treat type 2 diabetes mellitus. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of different forms of GLP-1 agonists on motor and non-motor functions of PD patients during ON-medication and OFF-medication states.

Assessing the Efficacy of Spinal Cord Stimulation in Managing Painful Diabetic Neuropathy: A Systematic Review and Meta-Analysis.

Background: Diabetes mellitus affects more than half a billion people globally, often leading to painful diabetic neuropathy (PDN). Spinal cord stimulation (SCS) has emerged as a promising treatment for PDN.

Objective: This meta-analysis evaluated the efficacy of SCS compared with the best medical therapy (BMT) for PDN.

Efficacy and safety of edaravone dexborneol in acute ischemic stroke: systematic review and meta-analysis of randomized controlled trials.

Introduction: Stroke is a leading cause of global morbidity and mortality, with acute ischemic stroke (AIS) accounting for most cases. Despite advancements in reperfusion therapies, many patients do not achieve sufficient reperfusion, necessitating effective neuroprotective interventions. This meta-analysis evaluates the efficacy and safety of Edaravone Dexborneol (ED) compared to standard therapies in AIS treatment.

Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials.

Novel treatments that act beyond the conventionally targeted monoamine system are urgently needed to provide more effective relief for patients with major depressive disorder. Pentoxifylline (PTX) is a phosphodiesterase inhibitor with potent anti-inflammatory and antioxidant effects, with additional pleiotropic effects. This is the first systematic review and meta-analysis to examine the role of PTX in major depressive disorder.

Medical students and ChatGPT: analyzing attitudes, practices, and academic perceptions.

Background: ChatGPT, a chatbot launched by OpenAI in November 2022, has generated both excitement and concern within the healthcare education, research, and practice communities. This study aimed to explore the knowledge, perceptions, attitudes, and practices of undergraduate medical students regarding the use of ChatGPT and similar chatbots in their academic work.

Methods: An anonymous, structured questionnaire was developed using Google Forms and administered to medical students as part of a cross-sectional study.

Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis.

Background: Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothelial function and reduce vascular wall inflammation. A growing body of research suggests that statins are associated with less risk of migraine, and they can be used to treat symptoms. However, the evidence has been inconclusive, so we aim to investigate the nature and strength of the effect of statins on the prevention and prophylaxis of migraines.

Revealing the diagnostic value of cerebrospinal fluid presepsin (sCD14) as a new biomarker for postneurosurgical and nosocomial central nervous system infections: A systematic review and meta-analysis of diagnostic test accuracy studies.

Background: Central nervous system (CNS) infections represent life-threatening conditions. Emerging evidence suggests cerebrospinal fluid (CSF) presepsin (sCD14) as a promising biomarker for these infections. However, its diagnostic accuracy remains controversial.

Delirium after deep brain stimulation for Parkinson's disease: a meta-analysis of incidence and risk factors.

Deep brain stimulation (DBS) is a valuable treatment for Parkinson's disease (PD), but postoperative delirium (POD) is a common complication. Understanding the risk factors for POD is crucial for optimizing patient selection and developing preventative measures. This systematic review and meta-analysis aims to identify predictors of POD in PD patients undergoing DBS surgery.

Effectiveness of non-invasive vagal nerve stimulation in Parkinson's disease: A comprehensive systematic review and meta-analysis.

Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms.

History of head trauma and the risk of multiple sclerosis: A systematic review and meta-analysis.

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system with unclear etiology involving genetic, environmental, and immunological factors. The potential link between head trauma and MS is controversial, with conflicting evidence. This systematic review and meta-analysis aim to assess the risk of developing MS following head trauma.

Effects of Non-invasive Vagus Nerve Stimulation on Inflammatory Markers in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The international healthcare community has encountered several difficulties because of the COVID-19 pandemic brought on by SARS-CoV-2. COVID-19 can lead to an abnormal immune response that features excessive inflammation, so targeting the vagus nerve through non-invasive vagus nerve stimulation (nVNS) may hold promise as an intervention. This meta-analysis aimed to examine the outcomes of using nVNS on different inflammatory biomarkers in COVID-19 patients.

The Prevalence of Musculoskeletal Pain and Assessment of Potential Risk Factors Among a Sample of Medical Students in Giza, Egypt.

Introduction: Musculoskeletal pain (MSP) is one of the most prevalent conditions among global medical students, affecting their daily lifestyle. In this study, we seek to determine the prevalence of MSP and its associated risk factors in a sample of medical students at Misr University for Science and Technology, Egypt.

Methods: A cross-sectional study was conducted between December 2023 and February 2024, with a sample size of 1472 students who filled out a modified version of the Standardized Nordic Questionnaire.

Comparative effectiveness and safety of eplerenone and spironolactone in patients with heart failure: a systematic review and meta-analysis.

Background: Eplerenone and spironolactone, recognized as mineralocorticoid receptor antagonists (MRAs), have been reported to improve clinical prognosis among individuals diagnosed with heart failure (HF). However, the difference in the clinical effects between eplerenone and spironolactone in individuals with HF remains uncertain. We aimed to assess the impact of eplerenone compared to spironolactone on clinical outcomes within the HF population.