Publications by authors named "Minh Khoa Ngo"
Article Synopsis
- The study identifies a noncanonical cleavage mechanism of the microprocessor complex (MP) that is responsible for processing certain pri-miRNAs, which the traditional model can't fully explain.
- The researchers analyzed a large dataset of pri-miRNA sequences to uncover this new mechanism, which does not require key RNA and protein components needed in the canonical process.
- This noncanonical mechanism is found to be conserved across various animal species and is particularly important in C. elegans, indicating a wider range of RNA substrates that the microprocessor can process, expanding our understanding of miRNA biogenesis.
Microprocessor (MP) is a complex involved in initiating the biogenesis of microRNAs (miRNAs) by cleaving primary microRNAs (pri-miRNAs). miRNAs are small single-stranded RNAs that play a key role in the post-transcriptional regulation of gene expression. Thus, understanding the molecular mechanism of MP is critical for interpreting the roles of miRNAs in normal cellular processes and during the onset of various diseases.
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