Benefit of coronary stenting using available intracoronary tools in high-risk patients. The OPTI-XIENCE study.

Background: The clinical benefit of using ICT for coronary stent optimization remains uncertain in randomized trials, in which a unique ICT was used in most cases.

Aim: To assess the clinical impact of intracoronary techniques (ICT) for stent optimization in high-risk patients.

Methods: The OPTI-XIENCE study is a prospective, observational, multicenter international study including high-risk patients undergoing coronary stenting, in whom any ICT was used for stent optimization at the operator's discretion.

Peer review of the pesticide risk assessment of the active substance prothioconazole.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, the United Kingdom and Poland, after Brexit and co-rapporteur Member State, France, for the pesticide active substance prothioconazole are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of prothioconazole as a fungicide on barley, wheat, oats, spelt, rye and triticale field crops and seeds.

Screening of organic pollutants in mollusc and fish samples from the Portuguese coast by combining liquid and gas chromatography with high resolution mass spectrometry.

In recent years, the presence of organic pollutants (OPs) in biota samples, especially in species which are intended for human consumption, has generated major concern. Thus, legislation on presence and levels has been created and/or updated in order to achieve safe food products for consumers. During the years 2020 and 2022 in the frame of the project "Contaminant levels in species of commercial interest captured in the Portuguese Maritime Area - CEIC", different species of fish and molluscs were collected in 4 main areas of the Portuguese coast.

Updated peer review of the pesticide risk assessment of the active substance fosetyl.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, France, and co-rapporteur Member State, Estonia, for the pesticide active substance fosetyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of fosetyl as a fungicide on grapes, citrus and pome fruits.

Anti-thrombotic and glucose lowering therapy in diabetic patients with coronary artery disease undergoing PCI with stent implantation: A prospective multicenter observational study on prescription patterns and clinical outcomes. Baseline inclusion data of the ARTHEMIS registry.

Introduction And Objectives: Diabetes is a major determinant of ischemic events after percutaneous coronary intervention (PCI). In a nationwide prospective registry, antiplatelet and glucose-lowering treatment regimens, and two-year clinical outcomes were studied in unselected patients with type 2 diabetes undergoing coronary stent implantation. The current analysis describes the population's baseline characteristics and the prescription patterns of anti-thrombotic and glucose-lowering drugs.

Updated peer review of the pesticide risk assessment of the active substance metalaxyl-M (amendment of approval conditions).

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Belgium, and co-rapporteur Member State, Greece, for the pesticide active substance metalaxyl-M are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative uses for the amendment to the conditions of approval of metalaxyl-M as a fungicide seed treatment for sunflower and spinach seeds intended to be sown in field and on the basis of data submitted to update the specified level of an impurity in the technical active substance.

Peer review of the pesticide risk assessment of the active substance maleic hydrazide.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessment carried out by the competent authority of the rapporteur Member State Belgium for the pesticide active substance maleic hydrazide are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Parliament and of the Council for an amendment in approval conditions. The purpose of this application was to lift the precaution to Member States to ensure, where appropriate, that the label of the treated crops includes the indication that the crops were treated with maleic hydrazide and the accompanying instructions to avoid exposure of the livestock.

Vision-related quality of life in spondyloarthritis patients with acute anterior uveitis on golimumab: the GO-VISION study.

Objectives: Acute anterior uveitis (AAU) associated with spondyloarthritis (SpA) is a common extra-articular manifestation, significantly impacting the health-related quality of life (HRQoL). The GO-VISION aimed to evaluate the effects of GOL on visual related (VR) and HRQoL, as well as health-related work productivity (HRWP), in individuals diagnosed with SpA and a history of SpA-AAU.

Methods: This prospective, multicentre study included 20 SpA patients with recent SpA-AAU, treated with GOL and followed for 48 weeks.

Peer review of the pesticide risk assessment of the active substance halosulfuron-methyl.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Italy and co-rapporteur Member State Poland for the pesticide active substance halosulfuron-methyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2020/103. The conclusions were reached on the basis of the evaluation of the representative use of halosulfuron-methyl as a herbicide in rice crops.

Updated peer review of the pesticide risk assessment of the active substance pydiflumetofen.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, France, and co-rapporteur Member State, Austria, for the pesticide active substance pydiflumetofen and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative uses of pydiflumetofen as a fungicide field application on pome fruits, grapes, potato, fruiting vegetables, cucurbits and vegetables and updated following the request from the Commission to consider additional information submitted and review the risk assessment.

Peer review of the pesticide risk assessment of the active substance formetanate (variant assessed formetanate hydrochloride).

The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Spain, and co-rapporteur Member State, Greece, for the pesticide active substance formetanate (variant assessed formetanate hydrochloride) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of formetanate (variant assessed formetanate hydrochloride) as an insecticide on tomatoes (field and greenhouses (permanent)) and on ornamentals (greenhouses (permanent)).

Updated peer review of the pesticide risk assessment of the active substance pelargonic acid (nonanoic acid).

The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Greece and co-rapporteur Member State Austria for the pesticide active substance pelargonic acid (nonanoic acid) and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative use of pelargonic acid as a herbicide on vineyards, potatoes, paths and places with woody plants, ornamental shrubs, ornamentals lawn, home gardens and allotments, paths and open areas with tree growth, woody ornamentals, decorative lawns, turf (field use).

Continuous Intra-arterial Infusion of Verapamil for Severe Vasospasm Treatment After Subarachnoid Hemorrhage: A Case Report.

Delayed cerebral ischemia can occur after subarachnoid hemorrhage (SAH) and is associated with the development of symptomatic vasospasm. Despite medical treatments for vasospasm, it can be refractory. Endovascular approaches, including bolus injection or continuous infusion of verapamil via in situ placement of a microcatheter, can serve as rescue therapy.

Peer review of the pesticide risk assessment of the active substance buprofezin.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Italy and co-rapporteur Member State Austria for the pesticide active substance buprofezin. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of buprofezin as an insecticide on ornamental plants in greenhouse via spray application.

Microplastics in the deep: Suspended particles affect the model species Mytilus galloprovincialis under hyperbaric conditions.

Microplastics (MPs) are small plastic particles that result from the degradation of bigger fragments or introduced into the environment as primary particles. Their reduced size makes them available for ingestion by marine organisms, particularly in subtidal and deep-sea environments, which represent the largest sinks for MPs in the ocean. However, there is a lack of data regarding the effects of MPs in subtidal and deep-sea ecosystems.

Cloning and comparative analysis of the retinoid X receptor in two marine gastropods with varying sensitivity to imposex under tributyltin contamination.

The Retinoid X Receptor (RXR) has been identified as a primary target in diverse endocrine disruption processes resulting from exposure to tributyltin (TBT), particularly concerning imposex development in gastropods. Two partial open reading frames encoding RXR were successfully isolated from the marine gastropods Buccinastrum deforme (BgRXR) and Trophon geversianus (TgRXR). These edible species, residing in the same area and exposed to similar environmental pollution conditions in Patagonia, Argentina, display different levels of imposex development.

Peer review of the pesticide risk assessment of the active substance maltodextrin.

The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Ireland, and co-rapporteur Member State, France, for the pesticide active substance maltodextrin and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2020/103. The conclusions were reached on the basis of the evaluation of the representative uses of maltodextrin as an insecticide and acaricide on all edible and non-edible crops.

Peer review of the pesticide risk assessment of the active substance pyraclostrobin.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Germany and co-rapporteur Member State Hungary for the pesticide active substance pyraclostrobin and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of pyraclostrobin as a fungicide and plant growth regulator on cereals (wheat, barley, oats, rye, triticale), maize (forage and grain) and potatoes.

Peer review of the pesticide risk assessment of the active substance daminozide.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Czech Republic and co-rapporteur Member State Hungary for the pesticide active substance daminozide are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of daminozide as a plant growth regulator in ornamentals (field and greenhouse).

Peer review of the pesticide risk assessment of the active substance clomazone.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Denmark, and co-rapporteur Member State, Germany, for the pesticide active substance clomazone are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of clomazone as a herbicide on potato and spring/winter oilseed rape.

Detection of iridocorneal angle changes after uncomplicated phacoemulsification using automated gonioscopy imaging.

Purpose: Phacoemulsification cataract surgery (PCS) is known to change anterior chamber morphology, widening the iridocorneal angle (ICA) of most patients. This study aims to determine whether automated gonioscopy imaging (AGI) with GS-1 (NIDEK CO., Japan) can detect changes in ICA morphology and pigmentation after PCS.

Peer review of the pesticide risk assessment of the active substance cyprodinil.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State France and co-rapporteur Member State Bulgaria for the pesticide active substance cyprodinil are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of cyprodinil as a fungicide on apples and barley.

Updated peer review of the pesticide risk assessment of the active substance spinosad.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, the Netherlands, and co-rapporteur Member State, France, for the pesticide active substance spinosad and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of spinosad as insecticide on bulb/dry onions, maize (fodder and grain), sweet corn, grapes (table and wine), lettuce, potato, aubergine, pepper and tomato.

Peer review of the pesticide risk assessment of the active substance lysate of C2c Maky.

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Austria for the pesticide active substance lysate of C2c Maky and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative use of lysate of C2c Maky as a fungicide against downy mildew () on grapevines and table grapes.