Acute myocardial infarction in a young patient with Chikungunya: a case report.

Chikungunya virus (CHIKV) is globally distributed and transmitted by Aedes mosquitoes, with a mortality rate of 0.8/1,000 cases. The heart is the second most affected organ, with the osteoarticular system being the first.

Evaluating the Effectiveness of NOACs and LMWH in Reducing Mortality in Critically Ill Patients With COVID-19.

Severe COVID-19 is associated with increased prothrombotic and inflammatory responses, necessitating effective anticoagulation therapy. Novel oral anticoagulants (NOACs) are being explored as potential alternatives to low-molecular-weight heparin (LMWH). This retrospective observational cohort study compared the effectiveness and safety of NOACs and LMWH in reducing mortality among 76 critically ill, unvaccinated patients with confirmed SARS-CoV-2 infection.

Not evolved to save the planet, yet capable to promote pro-environmental action leveraging human nature.

Anthropogenic environmental issues, from global warming to pollution, biodiversity loss, and natural resources depletion, require immediate action. Yet, inaction remains pervasive, and pro-environmental psychological interventions have, at best, yielded modest, short-lived effects. In this article, we argue that the development of more effective interventions could be aided by more nuanced discussion around two pervasive misguided assumptions: That human nature is inherently environmentally friendly, thus naturally inclined toward sustainability unless distorted by modern socioeconomic systems; on the other hand, that human nature is inherently destructive, posing a fundamental barrier to environmental action.

Anti-thrombotic and glucose lowering therapy in diabetic patients with coronary artery disease undergoing PCI with stent implantation: A prospective multicenter observational study on prescription patterns and clinical outcomes. Baseline inclusion data of the ARTHEMIS registry.

Introduction And Objectives: Diabetes is a major determinant of ischemic events after percutaneous coronary intervention (PCI). In a nationwide prospective registry, antiplatelet and glucose-lowering treatment regimens, and two-year clinical outcomes were studied in unselected patients with type 2 diabetes undergoing coronary stent implantation. The current analysis describes the population's baseline characteristics and the prescription patterns of anti-thrombotic and glucose-lowering drugs.

Role of N-terminal of metacaspase of Candida albicans in calcium binding.

Metacaspases are members of the CD clan and share structural similarities with mammalian caspases but possess unique features. This study delves into the Candida albicans metacaspase CaMCA-Ia, a type I metacaspase. CaMCA-Ia demonstrates Ca-dependent autoprocessing and presents a hydrophobic N-terminal, which differs from that of type II metacaspases.

Intercropping with Gramineous Plants in Nutrient Solutions as a Tool to Optimize the Use of Iron in .

This study aimed to evaluate the impact of intercropping . with three perennial grasses ( L., L.

Barriers and solutions for the European prescribing exam: a qualitative world café study.

Purpose: To harmonize and modernize clinical pharmacology and therapeutics (CPT) education across Europe, we developed the European Prescribing Exam. Before its introduction into medical degree programs, it is crucial to understand the potential barriers to its implementation and ways to overcome them. Therefore, the aim of this study was to identify barriers and potential solutions to the implementation of the European Prescribing Exam.

Astigmatid mites (Acari: Astigmata) as factitious prey for mass rearing Amblyseius largoensis (Acari: Phytoseiidae).

Predatory mites, particularly those of the Phytoseiidae family, play a key role in sustainable pest management by reducing pest populations and minimizing reliance on chemical pesticides. Amblyseius largoensis (Muma) (Acari: Phytoseiidae) is a generalist predator, with great potential for controlling noxious agricultural pests. However, large-scale rearing of A.

Temperature overcomes the effects of resource availability on the life history of Aedes aegypti mosquitoes, especially for females.

Mosquito-borne diseases pose a major public health challenge, with Aedes aegypti being a primary vector in subtropical regions. Temperature and resource availability are key environmental factors influencing mosquito development, survival, and fitness. However, the relative contributions of these factors, particularly under climate change scenarios, remain unclear.

Deep Learning Can Accurately Predict the Prognosis of Gynecologic Smooth Muscle Tumors of Uncertain Malignant Potential: A Multicenter Pilot Study.

Smooth muscle tumors of uncertain malignant potential (STUMP) of the gynecologic tract are a heterogeneous group of tumors, with ambiguous or worrisome features, whose biological behavior is difficult to predict. Several ancillary techniques have been used to try to predict their prognosis, with limited success. This study aimed to explore whether deep learning (DL)-based features can be used to predict progression-free survival (PFS) in STUMP and identify high-risk patients, directly from histological slides.

Dietary psychoactive xenobiotics: an updated review on food contamination with ergot, tropane and opium alkaloids and their toxicological effects.

Food contamination has been a major health issue since the beginning of human existence. Some food contaminants trigger important psychological manifestations, such as delirium, hallucinations, and psychosis, which may cause distress, aggravate pre-existing conditions, and dangerously interact with certain medications. Exposure to psychoactive food contaminants can ultimately lead to severe health problems or even death.

Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis.

Background: Approximately 50% of cases of recurrent pregnancy loss (RPL) remain unexplained, and there is a lack of consensus concerning the effective treatments for idiopathic RPL. We used network meta-analyses to evaluate the efficacy of several prophylactic therapeutic interventions used in women with idiopathic RPL.

Materials And Methods: We conducted a systematic literature search using several databases from their inceptions to 20 July 2023.

Genetic markers of thrombophilia as predictors of outcome in colorectal cancer.

Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for improving patients' clinical outcomes. Haemostatic components implicated in cancer-associated thrombosis (CAT) seem to favour CRC progression.

Automating Data Extraction from PDF Sleep Reports Using Data Mining Techniques.

This work introduces a web application for extracting, processing, and visualizing data from sleep studies reports. Using Optical Character Recognition (OCR) and Natural Language Processing (NLP), the pipeline extracts over 75 key data points from four types of sleep reports. The web application offers an intuitive interface to view individual reports' details and aggregate data from multiple reports.

[Costs and Consequences of Chronic Kidney Disease in People with Diabetes in Portugal: A Modelling Study].

Introduction: Chronic kidney disease is the fastest-growing chronic disease in terms of prevalence and one of the biggest causes of global mortality according to the Global Burden of Disease Collaboration. This study aimed to project the natural disease progression of this disease in people with diabetes, and to quantify the costs and consequences in the Portuguese context. This was achieved by developing an analytical model reflecting the epidemiology of chronic kidney disease and integrating the various stages of disease progression.

Predictive factors for pCR and relapse following neoadjuvant dual HER2-blockade in HER2+ breast cancer: an international cohort study.

Purpose: Neoadjuvant systemic therapy with dual HER2-blockade, trastuzumab and pertuzumab, combined with chemotherapy has become a standard approach in patients with HER2-positive (HER2+) breast cancer (BC). However, the variability in treatment outcomes, such as pathological complete response (pCR) or relapse rates, underscores the need to identify predictive factors to optimize therapeutic strategies. This study aims to explore the relationship between clinicopathological factors and both pCR and disease-free survival (DFS) in an international cohort of patients with HER2+ BC, contributing to defining personalized treatment strategies.

Medulloblastoma's master regulators and their association with patients' risk.

Medulloblastoma (MB) is the most common malignant pediatric brain tumor, accounting for approximately 20% of all childhood brain tumors. Despite recent advances, current treatments like surgery, radiation, and chemotherapy still lead to severe side effects and high morbidity. Limited knowledge exists regarding the regulatory mechanisms behind the MB transcriptional alterations in high-aggressive subgroups like Group 3 and Group 4, hindering the development of targeted therapies.

From selection to resistance: Mitochondrial findings in hookworm evolution under drug pressure.

Single nucleotide polymorphisms (SNPs) in codons 134, 167, 198, and 200 of the β-tubulin isotype 1 gene are associated with benzimidazole resistance in nematodes. Our group previously selected an Ancylostoma ceylanicum strain resistant to albendazole through drug-induced selective pressure, derived from a wild-type strain maintained under laboratory conditions for over 15 years. This study aimed to investigate mitochondrial genetic variability in the resistant strain compared to its wild-type counterpart.

Carotidynia: Nonsteroidal Anti-inflammatory Drug Treatment Resulting in Symptom Resolution Within Weeks.

Carotidynia, also known as Fay syndrome, is a rare vascular disorder characterized by continuous or intermittent lateral cervical pain in the region of the carotid artery bifurcation. It can be associated with various vascular and non-vascular processes and typically includes the presence of periadventitial thickening, with preservation of the lumen and without causing hemodynamic alterations. We present a case of a 45-year-old woman who was referred for an internal medicine consultation due to the presence of a foreign body sensation in the right cervical region.

Exploring TLR agonists as adjuvants for COVID-19 oral vaccines.

The COVID-19 pandemic underscored the importance of advancing technologies that enable the rapid development and distribution of more effective vaccines when required. Since SARS-CoV-2 enters the body through the nasal mucosa, optimising the induction of secretory IgA (sIgA) production, a key component of the mucosal immune response, is essential. It has long been known that the induction of sIgA occurs when a vaccine is administered through mucosal surfaces and the immune responses initiated at one mucosal site can influence immune activity at other mucosal surfaces.

Interaction between redox regulation, immune activation, and response to treatment in HER2+ breast cancer.

In HER2+ breast cancer (BC), neoadjuvant therapy represents an ideal scenario for translational research, considering pathological complete response (pCR) as an endpoint. In these patients, achieving pCR after neoadjuvant therapy is associated with a better prognosis. However, biomarkers are needed to tailor optimal treatment for each patient.

Association of Aspirin Use in Primary Prevention and Cardiovascular Events: A Retrospective Analysis of the VITAL Cohort.

Aspirin is part of the therapeutic antithrombotic armamentarium for the management of patients with established clinically relevant atherosclerosis or thrombotic cardiovascular disease. Personalized medicine identifies those who benefit most or face fewer risks from aspirin. The role of aspirin in primary prevention is still debatable.

Dynamics of Bagaza, West Nile, and Usutu Viruses in Red-Legged Partridges, Portugal, 2018-2022.

Long-term serologic surveillance of red-legged partridges suggests emergence of Bagaza virus in Portugal in 2021, associated with disease outbreaks in this species. Results also reveal sporadic circulation of Usutu virus and endemic circulation of West Nile virus, highlighting the role of red-legged partridges in the transmission and maintenance cycle and as sentinels of orthoflaviviruses.

Update on Treatments for Parkinson's Disease Motor Fluctuations - An International Parkinson and Movement Disorder Society Evidence-Based Medicine Review.

Objective: To update evidence-based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD).

Background: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated. The current review uses a new methodology, including the Cochrane Risk of Bias tool and a modified version of GRADE (Grading of Recommendations, Assessment, Development, and Evaluations).