On the Microcrystal Structure of Sputtered Cu Films Deposited on Si(100) Surfaces: Experiment and Integrated Multiscale Simulation.

Sputtered Cu/Si thin films were experimentally prepared at different sputtering pressures and characterized using X-ray diffraction (XRD) and an atomic force microscope (AFM). Simultaneously, an application-oriented simulation approach for magnetron sputtering deposition was proposed in this work. In this integrated multiscale simulation, the sputtered atom transport was modeled using the Monte Carlo (MC) and molecular dynamics (MD) coupling method, and the deposition of sputtered atoms was simulated using the MD method.

PGC-1α inhibits polyamine metabolism in Cyclin E1-driven ovarian cancer.

Aim: Cyclin E1-driven ovarian cancer (OvCa) is characterized with metabolic shift. In this study, we aim to pinpoint the metabolic pathway altered and assess its therapeutic potential.

Methods: In silico reproduction of TCGA ovarian cancer dataset and functional annotation using GSEA was performed.

GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer.

Aim: We previously found Cyclin E1-driven high grade serous ovarian cancer (HGSOC) showed metabolic shift. In this study, we aimed to elucidate signaling pathway therein.

Methods: In silico reproduction of TCGA ovarian cancer dataset and pathway analysis were performed.