Screening of lentil genotypes against stemphylium blight disease and molecular identification of causal organism.

During the cropping seasons of 2019-20, 2020-21, and 2021-22, respectively, lentil genotypes were screened against Stemphylium blight using the Alpha-Lattice Design with three replications at Pulses Research Centre, BARI, Ishurdi, Pabna-6620 under natural and artificial epiphytotic conditions. In case of artificial inoculum condition, the artificial cultured inoculums were sprayed at 1.3 × 10 spores/mL concentration of spores for spore inoculation in the experimental plots.

Punica granatum leaf extract as a natural antibacterial agent explored by experimental and computational methods.

The rise of multidrug-resistant (MDR) microorganisms, particularly Escherichia coli, poses a significant threat to global public health, necessitating the development of alternative treatments. This study investigates the antibacterial properties of methanolic Punica granatum (pomegranate) leaf extract (MPGL) against MDR E. coli and explores its potential as a source of natural inhibitors for the CTX-M-9 beta-lactamase enzyme, a key contributor to antibiotic resistance.

In silico screening of naturally derived dietary compounds as potential butyrylcholinesterase inhibitors for Alzheimer's disease treatment.

Alzheimer's disease (AD) is a progressive neurodegenerative condition that causes a substantial decline in cognitive functions and affects memory, thinking abilities, and daily behavior. The most prominent hallmark of AD pathogenesis is the formation of amyloid-β plaques, among other associated pathways such as neurofibrillary tangles, mitochondrial dysfunction, neuroinflammation, and oxidative stress. Butyrylcholinesterase (BuChE), an acetylcholine-degrading enzyme, plays a critical role in the progression of Alzheimer's disease, particularly through its involvement in amyloid-β plaque formation.

Bioinformatics-guided decoding of the Ancylostoma duodenale genome for the identification of potential vaccine targets.

Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia. Antimicrobial resistance to the available therapeutics has prompted the search for new drug and vaccine targets against A. duodenale.

Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches.

Cancer remains a significant global health challenge, with the Cell Division Cycle 7 (CDC7) protein emerging as a potential therapeutic target due to its critical role in tumor proliferation, survival, and resistance. However, a comprehensive analysis of CDC7 across multiple cancers is lacking, and existing therapeutic options have come with limited clinical success. The aim of this is to integrate a comprehensive pan-cancer analysis of CDC7 with the identification of novel marine-derived inhibitors, bridging the understanding of CDC7's role as a prognostic biomarker and therapeutic target across diverse cancer types.

Fungicide resistance profiles of spp. associated with fruit rot of blueberry in Georgia, USA.

Georgia blueberry growers experience significant losses annually due to fruit rots including Alternaria rot caused by spp. Fungicide applications from bloom through harvest are typically recommended for management of fruit rots, however fungicide resistance development has the potential to complicate management activities by reducing fungicide efficacy. To evaluate fungicide resistance issues in Georgia, 46 isolates of spp.

Comprehensive metabolite profiling and evaluation of anti-nociceptive and anti-inflammatory potencies of (Wurmb.) leaves: Experimental and in-silico approaches.

Globally, inflammation and pain are among the most prevalent health issues. The use of medicinal plants to alleviate these conditions is growing. This study comprehensively investigated the analgesic and anti-inflammatory properties of the ethyl-acetate extract of (EENF) leaves, traditionally used in folk Medicine.

A Comprehensive Evaluation of the Neuropharmacological Potential of Methanolic Leaf Extract of Acanthus ebracteatus (Vahl.) Using Experimental and In Silico Approaches.

This study was undertaken to assess the antioxidant and neuropharmacological potentials of the methanol leaf extract of Acanthus ebracteatus (MAEL) through experimental and in silico methods. The phytochemical screening (PS) and GC-MS (gas chromatography-mass spectrometry) identified 28 phytochemicals with different classes in nature in MAEL. The MAEL revealed better antioxidant activity through various in vitro antioxidant assays.

Heart rate variability parameters indicate altered autonomic tone in subjects with COVID-19.

COVID-19 is associated with long-term cardiovascular complications. Heart Rate Variability (HRV), a measure of sympathetic (SNS) and parasympathetic (PNS) control, has been shown to predict COVID-19 outcomes and correlate with disease progression but a comprehensive analysis that includes demographic influences has been lacking. The objective of this study was to determine the balance between SNS, PNS and heart rhythm regulation in hospitalized COVID-19 patients and compare it with similar measurements in healthy volunteers and individuals with cardiovascular diseases (CVD), while also investigating the effects of age, Body Mass Index (BMI), gender and race.

In Silico-Based Identification of Natural Inhibitors from Traditionally Used Medicinal Plants that can Inhibit Dengue Infection.

Dengue fever (DF) is an endemic disease that has become a public health concern around the globe. The NS3 protease-helicase enzyme is an important target for the development of antiviral drugs against DENV (dengue virus) due to its impact on viral replication. Inhibition of the activity of the NS3 protease-helicase enzyme complex significantly inhibits the infection associated with DENV.

Exploring antioxidative, cytotoxic and neuropharmacological insights into leaves: Experimental and approaches.

Background Study: The aim of this research was to examine possible antioxidant, cytotoxic and neurological activity of methanol and n-hexane extracts of leaves. Additionally, we aimed to identify potential lead compounds through analysis.

Methods: antioxidative properties were investigated through different assays, including: total phenolic content assay (TPC), total flavonoid content assay (TFC), DPPH free radical scavenging assay and reducing power assay.

Bioinformatics and Systems Biology Approaches to Identify the Synergistic Effects of Alcohol Use Disorder on the Progression of Neurological Diseases.

Clinical investigations showed that individuals with Alcohol Use Disorder (AUD) have worse Neurological Disease (ND) development, pointing to possible pathogenic relationships between AUD and NDs. It remains difficult to identify risk factors that are predisposing between AUD and NDs. In order to fix these issues, we created the bioinformatics pipeline and network-based approaches for employing unbiased methods to discover genes abnormally stated in both AUD and NDs and to pinpoint some of the common molecular pathways that might underlie AUD and ND interaction.

Neuropharmacological assessment and identification of possible lead compound (apomorphine) from through and approaches.

The aim of this research is to examine possible neurological activity of methanol, ethyl acetate, and aqueous extracts of and identify possible lead compounds through in silico analysis. , neuropharmacological activity was evaluated by using four distinct neuropharmacological assessment assays. Previously reported GC-MS data and earlier literature were utilized to identify the phytochemicals present in .

Sensitivity of spp. to benzimidazoles and dimethyl inhibitors fungicides and efficacy of biofungicides on dollar spot of warm season turfgrass.

Dollar spot caused by spp. (formerly ) is an economically destructive fungal disease of turfgrass that can significantly compromise turf quality, playability, and aesthetic value. Fungicides are frequently used to manage the disease but are costly and potentially unfavorable to the environment.

The pathogenetic influence of smoking on SARS-CoV-2 infection: Integrative transcriptome and regulomics analysis of lung epithelial cells.

Corona virus disease (COVID-19) has been emerged as pandemic infectious disease. The recent epidemiological data suggest that the smokers are more vulnerable to infection with COVID-19; however, the influence of smoking (SMK) on the COVID-19 infected patients and the mortality is not known yet. In this study, we aimed to discern the influence of SMK on COVID-19 infected patients utilizing the transcriptomics data of COVID-19 infected lung epithelial cells and transcriptomics data smoking matched with controls from lung epithelial cells.

Real-time face mask position recognition system based on MobileNet model.

COVID-19 is a highly contagious disease that was first identified in 2019, and has since taken more than six million lives world wide till date, while also causing considerable economic, social, cultural and political turmoil. As a way to limit its spread, the World Health Organization and medical experts have advised properly wearing face masks, social distancing and hand sanitization, besides vaccination. However, people wear masks sometimes uncovering their mouths and/or noses consciously or unconsciously, thereby lessening the effectiveness of the protection they provide.

Effects of spirulina as a functional ingredient in arsenic-induced broiler diet on growth performance and hematobiochemical parameters.

Objectives: The purpose of this research was to look into the impacts after the implication of feeding broiler chickens with spirulina in arsenic-incited toxicities.

Materials And Methods: Birds ( 125) were distributed equally ( 25) into four groups treated ( , , , ) and a group controlled, (normal feed and water without supplement), the group taking in arsenic trioxide (100 mg/l)-induced diet ( ), and the groups , , and (feed supplemented with 50, 100, and 200 mg/l of spirulina along with Arsenic Trioxide, respectively). The body weight and hematobiochemical parameters were recorded every 7 days.

Selection of Lentil ( (Medik.)) Genotypes Suitable for High-Temperature Conditions Based on Stress Tolerance Indices and Principal Component Analysis.

Legumes, including lentil, are a valuable source of carbohydrates, fiber, protein and vitamins and minerals. Their nutritional characteristics have been associated with a reduction in the incidence of various cancers, HDL cholesterol, type 2 diabetes and heart disease. Among these quality parameters, lectins have been associated with reducing certain forms of cancer, activating innate defense mechanisms and managing obesity.

Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes.

(Wall.) is extensively used in traditional medicine for the treatment of various diseases including rheumatism, kidney problems, jaundice, urinary tract disorders, fever, and pain. The present study was designed to explore new lead compound(s) to alleviate pain, pyresis, and diarrhea from methanol, ethyl acetate, and n-hexane extracts of (Wall.

sp. nov. Isolated from Roots of in Korea.

sp. nov. was isolated from the roots of halophyte collected from Seocheon-gun, Korea in November 2015.

Evaluation of the Tinetti score and fall risk assessment via accelerometry-based movement analysis.

Gait and balance disorders are among the main predisposing factors of falls in elderly. Clinical scales are widely employed to assess the risk of falling, but they require trained personnel. We investigate the use of objective measures obtained from a wearable accelerometer to evaluate the fall risk, determined by the Tinetti clinical scale.