Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review.

Background: Assessment of cognitive decline in the earliest stages of Alzheimer disease (AD) is important but challenging. AD is a neurodegenerative disease characterized by gradual cognitive decline. Disease stages range from preclinical AD, in which individuals are cognitively unimpaired, to mild cognitive impairment (MCI) and dementia.

Focus groups on digital cognitive assessment in the context of Alzheimer's disease.

Introduction: Digital cognitive assessments (DCAs) may facilitate early recognition of cognitive decline in the context of Alzheimer's disease (AD). While DCAs are increasingly emerging, they are often not used in practice. We assessed facilitators and barriers of using DCAs according to older individuals and patients.

Can MRI be used as a proxy for ? A case study.

  MRI has been used as an intermediate between brain histo(patho)logy and imaging. However, it is not known how comparable   is to imaging. We report the unique situation of a patient with familial early-onset Alzheimer's disease due to a mutation, who underwent brain MRI and   imaging only 4 days apart.

Fronto-limbic disconnection in patients with multiple sclerosis and depression.

Background: The biological mechanism of depression in multiple sclerosis (MS) is not well understood. Based on work in major depressive disorder, fronto-limbic disconnection might be important.

Objective: To investigate structural and functional fronto-limbic changes in depressed MS (DMS) and non-depressed MS (nDMS) patients.