Mangiferin and norathyriol acting on Alzheimer's disease biomarkers: acetylcholinesterase, β-secretase (BACE-1), and amyloid β-peptide.

Objectives: Mangiferin, a chemical constituent of Mangifera indica, has been the subject of extensive investigation due to its diverse biological activities, as detailed in numerous scientific studies. Its aglycone, norathyriol, has similarly garnered attention from researchers. In furtherance of our ongoing research goals, this article presents an evaluation of these compounds in relation to biomarkers associated with Alzheimer's disease.

Calcium anacardate and citric acid in starter diets for pullets reared on the floor.

The objective of this study was to evaluate the effects of combinations of calcium anacardate (CaA) and citric acid (CA) in the diet of layers between the 1st and 8th weeks of age, reared on the floor. A total of 960 1-day-age chicks were used in a completely randomized design with 8 treatments and 6 replicates with 20 birds per treatment. The treatments consisted of two control diets, negative (no additives) and positive (with anticoccidial additive-salinomycin), and 6 diets with the combinations: 0.

A new sesquiterpene from the heartwood of (Vell.) Arráb. ex Steud.

A new sesquiterpene, 8,11-epoxy-cadi-3,9-diene (), along with nine known compounds (-), were isolated from the heartwood of . Their structures were elucidated based on NMR spectroscopic data, and by comparison with data previously reported in literature. The hexane extract from the heartwood of , the EtOH extract from the heartwood of , the CHCl-soluble fraction of the EtOH extract, the EtOAc-soluble fraction of the EtOH extract and the compounds - have been evaluated as acetylcholinesterase inhibitors, and among these, the extracts and fractions exhibited satisfactory results.

Comparison of α and β-acid isomerization in hops and beer using HPLC, confocal microscopy, spectrofluorimetry and chemical analysis of metabolites and essential oils in flowers of different hop cultivars produced in Brazil.

We used confocal microscopy and spectrofluorescence to characterize the emission spectra in hop flowers, to follow the isomerization processes in different hop preparations, and beers, to compare with HPLC extracted samples. Flowers of different hop cultivars produced in three regions of Brazil, were quantitated by HPLC and GC-MS. The fluorescence spectra showed two characteristic emission bands evaluated from different preparations.

Calcium anacardate and its association with citric acid in diets for meat-type breeding quails.

The purpose of this study was to evaluate the effects of using calcium anacardate (CaA) as a source of anacardic acid and its association with citric acid (CA) in diets for breeding quails on the performance, the egg quality, incubation parameters, and progeny performance. Were used 540 quails European quails (Coturnix coturnix coturnix) that were 21 weeks old, housed in laying cages based on a completely randomized design, with nine treatments and six replications of 10 quails per parcel, with each experimental unit having eight females and two males. The following additions to the diet were evaluated: 1, no addition (control diet); 2, 0.

Cardanol in the feeding of meat-type quail breeders.

The purpose of this study was to evaluate the inclusion of cardanol in the diet of quails on productive performance, egg quality, reproductive performance, and progeny performance. A total of three hundred European quail breeders of 32 weeks of age, with average body weights of 305.98 g, were housed in laying cages in groups (4 females and 1 male), following a distribution in a completely randomized design with 5 treatments and 6 replications of 10 quails, being the experimental unit constituted by the set of two cages.

extract reverses anxiety and seizure behavior in adult zebrafish through GABAergic neurotransmission: an study.

are reported in the literature for presenting neuroprotective and anxiolytic effects in animal models. has few scientific reports on its pharmacological effects. The aim of this study was to evaluate the anxiolytic and anticonvulsant effects of the ethanol extract from the leaves of (EtFoCl) and its possible mechanism of GABAergic action in adult zebrafish.

: chemical constituents, antioxidant and alpha-glucosidase inhibitory activities.

Phytochemical investigation of the stems of led to the isolation of the known compounds identified as a mixture of taraxerone () and βamirenone (), a mixture of sitosterol () and stigmasterol (), 2-hydroxy-3,5-dimethoxybibenzyl (), 3',4'-dihydroxyphenyl-chroman-7-ol (), fisetinidol (), epicatechin (), guibourtinidol (), vanillic acid (), 6'-vanilloylisotachioside () and 6'--syringoylisotachioside (). The structures of these compounds were elucidated on the basis of their NMR spectroscopic data. The antioxidant activity of compound has been investigated using DPPH° and ABTS° assays and the results showed inhibition in the both models.

Cashew apple pectin as a carrier matrix for mangiferin: Physicochemical characterization, in vitro release and biological evaluation in human neutrophils.

In this work, cashew apple pectin (CP) of the species Anacardium occidentale L. was used as an encapsulation matrix for hydrophobic drugs. The model drug chosen was mangiferin (Mf), a glycosylated C-xanthone which has antioxidant properties but low solubility in aqueous medium.

Chemical constituents and acetylcholinesterase inhibitory activity from the stems of .

Two steroids ( and ), two oxepin derivatives ( and ) and seven flavonoids (-) were isolated from the stems of . Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in the literature. The ethanol extract from the stems of and the compounds, , , , , and have been evaluated as acetylcholinesterase inhibitors, and among these, the compound exhibited the strongest activity.

Chromium (VI) remediation in aqueous solution by waste products (peel and seed) of mango (Mangifera indica L.) cultivars.

The surface group characteristics of mango cultivar peels and seeds were evaluated by infrared spectra, PZC, and functional group composition. The adsorption/reduction of chromium (VI) in aqueous solutions was investigated by varying pH, contact time, initial Cr(VI) concentration, and adsorbent amount. The results show that both peel and seed powders of the mango cultivars showed significant adsorption/reduction capacity for Cr(VI) and that the desorption process obeys pseudo-second-order kinetics.

Nutraceutical compounds: Echinoids, flavonoids, xanthones and caffeine identified and quantitated in the leaves of Coffea arabica trees from three regions of Brazil.

There are relatively few studies concerning the use of coffee leaves for medicinal purposes and the composition of secondary plant substances. Therefore, we identified and quantitated polyphenolic compounds along with caffeine present in methanol extracts of Coffea arabica leaves from three different regions of Brazil (Ceará, Minas Gerais and São Paulo) by HPLC-ESI-MS. In addition, correlations between polyphenolic content of the coffee leaves and antioxidant assays DPPH, FRAP and ORAC were evaluated.

Pesticide analysis in coffee leaves using a quick, easy, cheap, effective, rugged and safe approach and liquid chromatography tandem mass spectrometry: Optimization of the clean-up step.

An analytical method using a quick, easy, cheap, effective, rugged and safe (QuEChERS) procedure for multi-residue determination of 52 pesticides in coffee leaf extractshas been developed and validated according to SANTE/11945/2015 guidelines. Different sorbent combinations for dispersive solid phase extraction (d-SPE) clean-up as well as dispersive liquid-liquid microextraction (DLLME) were tested. The relative standard deviations (RSDs) for the recovery of 87-94% of pesticides added to coffee leaf extracts,was ≤20% for samples spiked at concentrations up to 50ng*g depending on the clean-up procedures.

Luminescent Ru(II) Phenanthroline Complexes as a Probe for Real-Time Imaging of Aβ Self-Aggregation and Therapeutic Applications in Alzheimer's Disease.

The complexes cis-[Ru(phen)(Apy)], Apy = 4-aminopyridine and 3,4-aminopyridine, are stable in aqueous solution with strong visible absorption. They present emission in the visible region with long lifetime that accumulates in the cytoplasm of Neuro2A cell line without appreciable cytotoxicity. The complexes also serve as mixed-type reversible inhibitors of human AChE and BuChE with high active site contact.

Effect of dietary ethanol extracts of mango (Mangifera indica L.) on lipid oxidation and the color of chicken meat during frozen storage.

The aim of this study was to evaluate the dietary effect of mango extracts on lipid stability and the coloring of broiler chicken breast meat during frozen storage. The treatments consisted of broiler chicken diet without antioxidants (control) and diets containing antioxidants: 200 ppm of butylated hydroxytoluene (BHT), 200 ppm of mango peel extract (MPE), 400 ppm of MPE, 200 ppm of mango seed extract (MSE), and 400 ppm of MSE. The broiler breasts were stored for 90 days and analysis of lipid oxidation and color was performed every 30 days.

Mangiferin ameliorates the intestinal inflammatory response and the impaired gastrointestinal motility in mouse model of postoperative ileus.

Our previous study has shown that mangiferin (MGF), a glucosylxanthone from Mangifera indica, exerts gastrointestinal prokinetic action involving a cholinergic mechanism. Postoperative ileus (POI) is a temporary disturbance in gastrointestinal motility following surgery, and intestinal inflammatory response plays a critical role in the pathogenesis of POI. The present study investigated to know whether MGF having anti-inflammatory and prokinetic actions can ameliorate the intestinal inflammation and impaired gastrointestinal transit seen in the mouse model of POI.

Anacardic acids from cashew nuts ameliorate lung damage induced by exposure to diesel exhaust particles in mice.

Anacardic acids from cashew nut shell liquid, a Brazilian natural substance, have antimicrobial and antioxidant activities and modulate immune responses and angiogenesis. As inflammatory lung diseases have been correlated to environmental pollutants exposure and no reports addressing the effects of dietary supplementation with anacardic acids on lung inflammation in vivo have been evidenced, we investigated the effects of supplementation with anacardic acids in a model of diesel exhaust particle- (DEP-) induced lung inflammation. BALB/c mice received an intranasal instillation of 50  μ g of DEP for 20 days.

Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism.

Aim: To investigate the effects of mangiferin on gastrointestinal transit (GIT) in normal and constipated mice, together with the possible mechanism.

Methods: Intragastrically-administered charcoal meal was used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin (3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po) or tegaserod (1 mg/kg, ip) were administered 30 min before the charcoal meal to study their effects on normal transit.

Acute, subacute toxicity and mutagenic effects of anacardic acids from cashew (Anacardium occidentale Linn.) in mice.

Aim Of The Study: Anacardium occidentale Linn. (cashew) is a Brazilian plant that is usually consumed in natura and is used in folk medicine. Anacardic acids (AAs) in the cashew nut shell liquid are biologically active as gastroprotectors, inhibitors of the activity of various deleterious enzymes, antitumor agents and antioxidants.

Characterization of the volatile pattern and antioxidant capacity of essential oils from different species of the genus Ocimum.

The antioxidant capacity of essential oils obtained by steam hydrodistillation from five species of the genus Ocimum, namely Ocimum basilicum var. purpurascens, Ocimum basilicum, Ocimum gratissimum, Ocimum micranthum, and Ocimum tenuiflorum (syn. O.