One-time double-layer placement of controlled-release urea enhances wheat yield, nitrogen use efficiency and mitigates NO emissions.

Simultaneously enhancing the crop yield and reducing nitrous oxide (NO) emissions presents a critical challenge in sustainable agriculture. The application of nitrogen (N) fertilizer is a key strategy to enhance crop yield. However, conventional N application practices often lead to excessive soil N accumulation, insufficient crop N uptake and elevated greenhouse gas (GHG) emissions.

Explicit analysis of , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial strategies.

Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically successful targeted delivery of nanomedicines, it is crucial to understand why well-designed nanomedicines often fail during clinical trials.

Areas Covered: This review comprehensively explores the multifactorial reasons behind the poor clinical success rate of nanomedicines, including pathophysiological complexity, limitations in statistical analysis, inadequate animal models, variability in the EPR effect, and manufacturing challenges.

Decrease in shear wave elastography values and associated risk factors in patients of NAFLD with Unani treatment: clinical case series.

Introduction: Non-alcoholic Fatty Liver Disease (NAFLD) is a global health concern, and leading cause of liver cirrhosis and carcinoma, with no approved treatment till date. In Unani medicine, the management of fat deposition in liver is done with mufatteḥ-i-sudad (de-obstruent) and muḥallil-i-waram (anti-inflammatory) drugs, to expel morbid matter and restore hepatic functions. This study was done to evaluate the efficacy of Unani drugs in NAFLD on specific biochemical and radiological parameters.

Microbial Symbiosis in Lepidoptera: Analyzing the Gut Microbiota for Sustainable Pest Management.

Recent advances in microbiome studies have deepened our understanding of endosymbionts and gut-associated microbiota in host biology. Of those, lepidopteran systems in particular harbor a complex and diverse microbiome with various microbial taxa that are stable and transmitted between larval and adult stages, and others that are transient and context-dependent. We highlight key microorganisms-including , , , , , , , , , and -that play critical roles in microbial ecology, biotechnology, and microbiome studies.

A tale of two valves: where rheumatic mitral disease meets aortic papillary fibroelastoma - a narrative review.

Rheumatic heart disease (RHD) and papillary fibroelastoma (PFE) are distinct cardiovascular disorders that can rarely occur together. RHD is a chronic condition caused by untreated streptococcal infections, primarily affecting the mitral valve and resulting in severe valvular damage. On the other hand, PFE is a benign heart tumor, usually affecting the aortic valve, and is typically asymptomatic, often discovered incidentally through imaging.