Development and validation of a risk prediction model for acute chemotherapy-induced nausea and vomiting in pediatric patients with cancers.

Background: Acute chemotherapy-induced nausea and vomiting (CINV) affects 80-95% of pediatric cancer patients, with distinct risk patterns from adults, yet few risk prediction models exist for this population. We aimed to develop and validate a prediction model for acute CINV in pediatric patients with cancers, providing a tool to guide the clinical implementation of CINV prophylaxis and reduce CINV occurrence in children.

Methods: A total of 378 hospitalized children who underwent chemotherapy at the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, between August 1, 2022, and March 31, 2023, were enrolled.

Silane cooperation with Ce(SO) to efficiently construct a protective layer and induce uniform deposition of Zn for an ultra-stable Zn anode.

Aqueous Zn ion batteries (ZIBs) are gaining interest for use in large-scale energy storage systems due to their intrinsic safety, low cost, and sustainability. Unfortunately, water-induced side reactions and dendrite growth on the Zn anode have severely hampered their further development. Herein, 3-aminopropyltrimethoxysilane (KH-540) was employed as an electrolyte additive to construct an organic-inorganic solid-electrolyte interface (SEI) layer comprising zinc hydroxy sulfate and polysiloxane to alleviate the side reactions and inhibit dendrite growth.

The relationship between biological aging and psoriasis: evidence from three observational studies.

Background: The relationship between psoriasis and aging remains unclear. Biological age is considered as a tool for strong association with aging, but there is a lack of reports on the relationship between biological age and psoriasis. Therefore, this study aimed to explore the relationship between biological age and psoriasis.

construction of a static-dynamic hybrid interface toward stable Zn anodes for aqueous Zn-ion batteries.

Aqueous Zn-ion batteries are promising candidates for next-generation energy storage devices due to the advantages of high safety, low cost and good environmental friendliness. However, the uncontrollable dendrite growth and undesirable side reactions occurring on the Zn anode result in poor cycling stability. Herein, a Lewis base, triethanolamine, is used as the electrolyte additive to construct a hybrid solid-electrolyte interphase layer composed of a static ZnSO·3Zn(OH)·4HO layer and dynamic quaternary ammonium ion adsorption layer.

Development of a Prediction Model and Corresponding Scoring Table for Postherpetic Neuralgia Using Six Machine Learning Algorithms: A Retrospective Study.

Introduction: Postherpetic neuralgia (PHN), a complication of herpes zoster, significantly impacts the quality of life of affected patients. Research indicates that early intervention for pain can reduce the occurrence or severity of PHN. This study aims to develop a predictive model and scoring table to identify patients at risk of developing PHN following acute herpetic neuralgia, facilitating informed clinical decision-making.

Metabolic dysfunction associated steatotic liver disease in patients with plaque psoriasis: a case-control study and serological comparison.

Background: The relationship between plaque psoriasis and both MASLD and lean MASLD has not been sufficiently explored in the current literature.

Method: This retrospective and observational study was carried out from January 2021 to January 2023 at The First Affiliated Hospital of Zhejiang Chinese Medical University. Patients diagnosed with plaque psoriasis and a control group consisting of individuals undergoing routine physical examinations were enrolled.

Body Mass Index Affects Delayed Chemotherapy-induced Vomiting in Pediatric Malignancy Patients.

Background: Delayed chemotherapy-induced vomiting (DCIV) is a problem for children undergoing chemotherapy for malignant tumors. The aim of this study was to investigate the association between body mass index (BMI) and DCIV in children.

Patients And Methods: Clinical data were collected from patients with malignancies who underwent chemotherapy at our center.

-Acetyl-l-cysteine ameliorates gestational diabetes mellitus by inhibiting oxidative stress.

Gestational diabetes mellitus (GDM) affects 7% of pregnant women worldwide. How to effectively treat GDM has always been a concern of people. In this study, a diabetes model was established by drug-induced mice.

Facile Fabrication of Superhydrophobic and Flame-Retardant Coatings on Cotton Fabrics.

The hydrophilicity and inherent flammability of cotton textiles severely limit their usage. To solve these drawbacks, a superhydrophobic and flame-retardant (SFR) coating made of chitosan (CH), ammonium polyphosphate (APP), and TiO-SiO-HMDS composite was applied to cotton fabric using simple layer-by-layer assembly and dip-coating procedures. First, the fabric was alternately immersed in CH and APP water dispersions, and then immersed in TiO-SiO-HMDS composite to form a CH/APP@TiO-SiO-HMDS coating on the cotton fabric surface.

Metastable spiking networks in the replica-mean-field limit.

Characterizing metastable neural dynamics in finite-size spiking networks remains a daunting challenge. We propose to address this challenge in the recently introduced replica-mean-field (RMF) limit. In this limit, networks are made of infinitely many replicas of the finite network of interest, but with randomized interactions across replicas.

MicroRNA-486-5p down-regulation protects cardiomyocytes against hypoxia-induced cell injury by targeting IGF-1.

Background: MicroRNA has been reported to play an important role in congenital heart disease (CHD) in children. Recently, microRNA-486-5p (miR-486-5p) has been found increased in patients with cyanotic heart disease compared with those without heart disease. The present study aimed to investigate the effect of miR-486-5p on hypoxia-induced cardiomyocyte injury to reveal the role of miR-486-5p in cyanotic congenital heart disease (CCHD).

NOD-like receptor protein 3 and high mobility group box-1 are associated with prognosis of patients with congenital heart disease.

Objective: To investigate the association between plasma levels of nucleotide-binding oligomerization domain-like (NOD)-like receptor protein 3 (NLRP3) and high mobility group box-1 (HMGB1) and their prognostic significance in neonatal patients with congenital heart disease (CHD).

Methods: This study enrolled neonatal patients with CHD and collected their demographic and clinical data. Plasma concentrations of NLRP3 and HMGB1 were measured using enzyme-linked immunosorbent assays.

Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats.

Coronary microvascular dysfunction (CMD) is the pathological basis and pathogenesis of diabetic cardiomyopathy (DCM). Propylene glycol alginate sodium sulfate (PSS) as heparinoid drug has many biological activities. Here, a novel PSS-loaded nanoparticle (PSS-NP) was prepared to study its effect on the CMD of DCM.

Topological Transitions Induced by Antiferromagnetism in a Thin-Film Topological Insulator.

Magnetism in topological insulators (TIs) opens a topologically nontrivial exchange band gap, providing an exciting platform for manipulating the topological order through an external magnetic field. Here, we show that the surface of an antiferromagnetic thin film can magnetize the top and the bottom TI surface states through interfacial couplings. During the magnetization reversal, intermediate spin configurations are ascribed from unsynchronized magnetic switchings.