Zn single-atom sites/Ru nanoclusters synergistically inducing reactive oxygen species storm for ultrasensitive electrochemiluminescence detection of biomarker PSA.

Improving the sensitivity of electrochemiluminescence (ECL) systems is crucial for bio-marker detection and prostate cancer diagnosis, as early-stage prostate cancer exhibits low biomarkers levels. In this work, satellite Zn single-atom sites/Ru nanoclusters anchored on N-rich porous carbon (Zn SAs/Ru NCs) was synthesized by high-temperature pyrolysis under N atmosphere. The Zn SAs/Ru NCs synergistically induced reactive oxygen species (ROS) storm andboosted luminol signals in the absence of HO, eliminating the effect of unstable HO.

Thermal-responsive luminescence/dielectric responses with reversibly shifted light emissions.

Molecular-rotor-type crystals dominated by crown ethers have garnered significant attention for their applications in sensing, optoelectronics, information encryption and other diverse fields. However, the role of crown ethers in regulating photoluminescent properties has long been overlooked in such structural systems. Here, by inserting 18-crown-6 molecules into the ionic crystal (4-pyridinemethaneaminum)PF (PP-1), we constructed a molecular-rotor-type crystal [(4-pyridinemethaneaminum)(18-crown-6)][PF] (PCP-1), exhibiting sensitively thermal-driven, unusual PL/dielectric responses.

Facile pyrolysis synthesis of abundant FeCo dual-single atoms anchored on N-doped carbon nanocages for synergistically boosting oxygen reduction reaction.

Single-atom transition metal-based nitrogen-doped carbon (M-N-C) is regarded as high-efficiency and cost-effectiveness alternatives to replace noble metal catalysts for oxygen reduction reaction (ORR) in renewable energy storage and conversion devices. In this work, rich FeCo dual-single atoms were efficiently entrapped into N-doped carbon nanocages (FeCo DSAs-NCCs) by simple pyrolysis of the bimetallic precursors doped zeolitic imidazolate framework-8 (ZIF-8), as affirmed by a series of characterizations. The graphitization degree of the N-doping carbon substrate was regulated by modulating the pyrolysis temperature and the types of the metal salts.

[Protective effect of grape seed proanthocyanidin on cultured RGC-5 cells against CoCl2-induced hypoxic injury].

Objective: To investigate the protective effects of grape seed proanthocyanidin extracts (GSPE) against CoCl2-induced hypoxic injury in cultured RGC-5 cells.

Methods: CoCl2(400 μmol/L) was used to induce hypoxic injury in cultured RGC-5 cells; the cells were pretreated with 0,100,200,400 and 800μmol/L GSPE for 24h. The cell viability was assayed by MTT; the apoptosis was detected by Hoechst 33342 staining; the intracellular reactive oxygen species (ROS) was measured by H2DCFDA oxidative reaction.

Vascular lumen simulation and highly-sensitive nitric oxide detection using three-dimensional gelatin chip coupled to TiC/C nanowire arrays microelectrode.

Reproducing the physiological environment of blood vessels for the in vitro investigation of endothelial cell functions is very challenging. Here, we describe a vascular-like structure based on a three-dimensional (3D) gelatin chip with good compatibility and permeability which is also cost-effective and easy to produce. The controllable lumen diameter and wall thickness enable close mimicking of blood vessels in vitro.

Integrated microdevice for long-term automated perfusion culture without shear stress and real-time electrochemical monitoring of cells.

Electrochemical techniques based on ultramicroelectrodes (UMEs) play a significant role in real-time monitoring of chemical messengers' release from single cells. Conversely, precise monitoring of cells in vitro strongly depends on the adequate construction of cellular physiological microenvironment. In this paper, we developed a multilayer microdevice which integrated high aspect ratio poly(dimethylsiloxane) (PDMS) microfluidic device for long-term automated perfusion culture of cells without shear stress and an independently addressable microelectrodes array (IAMEA) for electrochemical monitoring of the cultured cells in real time.

Monitoring of vesicular exocytosis from single cells using micrometer and nanometer-sized electrochemical sensors.

Communication between cells by release of specific chemical messengers via exocytosis plays crucial roles in biological process. Electrochemical detection based on ultramicroelectrodes (UMEs) has become one of the most powerful techniques in real-time monitoring of an extremely small number of released molecules during very short time scales, owing to its intrinsic advantages such as fast response, excellent sensitivity, and high spatiotemporal resolution. Great successes have been achieved in the use of UME methods to obtain quantitative and kinetic information about released chemical messengers and to reveal the molecular mechanism in vesicular exocytosis.

Translation of an effective tai chi intervention into a community-based falls-prevention program.

Tai chi--moving for better balance, a falls-prevention program developed from a randomized controlled trial for community-based use, was evaluated with the re-aim framework in 6 community centers. The program had a 100% adoption rate and 87% reach into the target older adult population. All centers implemented the intervention with good fidelity, and participants showed significant improvements in health-related outcome measures.

Aerial lift fall injuries: a surveillance and evaluation approach for targeting prevention activities.

Problem: Work on aerial lift platforms exposes workers to fall hazards. The objective of this study was to identify the most common injury scenarios and determine current research gaps for addressing fall incidents associated with aerial lifts.

Methods: Three databases were searched: Census of Fatal Occupational Injuries (CFOI), NIOSH Fatality Assessment and Control Evaluation (FACE) reports, and OSHA Incident Investigation Records.

The provisional license: nighttime and passenger restrictions--a literature review.

Problem: Due to inexperience and inadequate driving skills, the road is a very risky place for young and beginning drivers, yet such experience and skills can only be built by increased driving and exposure to risks on the road. Graduated driver licensing (GDL) allows beginning drivers to get their initial driving experience under less risky conditions and gradually eases them into more complex driving situations. This paper reviews the literature exploring two key features of the intermediate licensing phase of GDL, nighttime driving restrictions and passenger restrictions.