Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case.

Background: Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).

Observations: The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.

Lessons: Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients.

[Analysis of a case of Kabuki syndrome due to a novel variant of KMT2D gene].

Objective: To report on a case of Kabuki syndrome (KS) due to a novel variant of KMT2D gene.

Methods: A child diagnosed with KS at the Fujian Children's Hospital on July 25, 2022 was selected as the study subject. Whole exome sequencing was carried out for the child and her parents.