Noninvasive in vivo tracking of SPIONs-labeled CLDN18.2-targeted CAR-T cells in gastric cancer via magnetic particle imaging.

This study aims to employ magnetic particle imaging (MPI) for in vivo tracking and quantitative assessment of targeting capability of CLDN18.2-specific CAR-T cells. CLDN18.

Research on blasting damage to tunnel surrounding rock based on acoustic full waveform signal analysis.

In order to study the application of Acoustic Full Waveform Signal analysis in blasting damage to tunnel surrounding rock, a formula for blasting damage increment considering cumulative effects was proposed by analyzing the Acoustic Full Waveform Signal before and after blasting, based on the concepts of elastic waves and damage degree. This formula allows the cumulative damage law of surrounding rock blasting to be calculated and analyzed. Furthermore, by introducing the Lorentz curve, Gini coefficient, and fractal theory, and combining them with the surrounding rock blasting damage law, their practicality in studying blasting damage was verified.

Cumulative damage characteristics of tunnel initial support concrete under blasting load.

Relying on the Beijing-Zhangjiakou high-speed railway Cao Mao Shan tunnel project, blasting vibration monitoring and sound wave testing experiments were carried out. The monitoring results show that the blasting vibration velocity corresponding to the initial support satisfies the Sadowski formula. The results of the sonic test show that with the increase of blasting times, the cumulative damage increases gradually, but the blasting damage increment shows a downward trend.

Damage prediction and improvement method based on cutting mode of circular empty hole.

Based on the theory of empty hole effect of cutting blasting, the Hopkinson effect and Saint-Venant principle are integrated to establish a two-dimensional calculation model of dynamic stress evolution of the holes wall, and then the dynamic fracture mechanism and damage distribution mode of the rock mass in the cutting area under the action of longitudinal waves are predicted. The results of the calculation and numerical simulation are verified by experiments, and the results show that: The time-varying stress function of the circular cavity wall conforms to the periodic dynamic evolution of the trigonometric function, and the theoretical calculation is consistent with the simulation results. Through the calculation of the round holes cut model and the square empty hole cut model, the change of the shape of the holes in the cut area changes the failure form of the surrounding rock mass.

, a Germin-like Protein from Maize, Plays an Important Role in the Regulation of Pathogen Resistance.

A gene encoding a protein similar to germin-like proteins (GLPs) was obtained from maize () and designated as . Based on the conserved domain and phylogenetic status, was grouped into GLP subfamily b and has high similarity to from . is expressed in different maize tissues during different growth stages and is mainly expressed in the stems and leaves.