The role of angiotensin receptor/neprilysin inhibitor in moderate ischemic mitral regurgitation after isolated coronary artery bypass grafting (ARNI-MIMIC): study protocol for a randomized controlled trial.

Debates have been existed regarding the treatment of moderate ischemic mitral regurgitation (IMR) in patients undergoing coronary artery bypass grafting (CABG). While it might have priority on reducing the risk of recurrent IMR, studies showed that concomitant mitral valve repair increases the risk of adverse outcomes, such as neurological events, as well as the in-hospital costs. In recent studies, angiotensin receptor-neprilysin inhibitor (ARNI) was discovered to have potential benefit in reducing the severity of IMR.

[Meta-analysis of hydrocortisone in the treatment of severe community-acquired pneumonia].

Objective: To explore whether hydrocortisone can improve the prognosis of patients with severe community-acquired pneumonia (sCAP) by Meta-analysis.

Methods: Randomized controlled trial (RCT) on hydrocortisone in the treatment of sCAP were extracted from the database including PubMed, Cochrane library, Web of Science, and Embase, and the search time was up to April 29, 2023. The patients in the standard treatment group received standard treatment such as antibiotics and supportive care, while those in the hydrocortisone group received hydrocortisone treatment on the basis of standard treatment.

Sub-4 nanometer porous membrane enables highly efficient electrodialytic fractionation of dyes and inorganic salts.

During the synthesis of dyes, desalination of high-salinity dye-containing waste liquor is a critical premise for high-quality, clean dye production. Conventional membrane processes, such as electrodialysis, nanofiltration and ultrafiltration, are inevitably subjected to serious membrane fouling, deteriorating the dye/salt fractionation efficacy. Integrating the technical merits of electrodialysis and pressure-driven membrane separation, we devise an electro-driven filtration process using a tight ultrafiltration membrane as alternative to conventional anion exchange membrane for rapid anion transfer, in view of dye desalination and purification.

Glucocorticoids can reduce mortality in patients with severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials.

Background: Severe community-acquired pneumonia (sCAP) is associated with higher morbidity and mortality. The use of glucocorticoids to improve the prognosis of severe community-acquired pneumonia remains a topic of controversy.

Methods: Following the guidelines given in the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA), we conducted a systematic review and meta-analysis to evaluate the effects of glucocorticoids on mortality and duration of mechanical ventilation in patients with sCAP.

Preoperative D-dimer level predicts adverse events after coronary endarterectomy combined with coronary artery bypass grafting: a retrospective cohort study.

Background: Little is known about the role of D-dimer (DD) on the prognosis of patients undergoing coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG).

Methods: A total of 371 patients undergoing CE with CABG between January 2018 and July 2022 were retrospectively enrolled. The primary endpoint was the perioperative major adverse cardiovascular and cerebrovascular events (MACCE).

The Association between Non-Alcohol Liver Fatty Disease and Coronary Artery Calcification: A Two-Sample Mendelian Randomization Study.

Background: Although prior observational studies have suggested that patients with non-alcohol fatty liver disease (NAFLD) may have a higher risk of coronary artery calcification (CAC), these findings remain controversial. This study aimed to explore the causal association between NAFLD and CAC at genetic level by two-sample Mendelian randomization (MR) analysis.

Method: Utilizing summary-level data from multiple large-scale genome-wide association studies (GWAS) in European populations, a two-sample MR analysis was initially conducted to explore the potential causal association between NAFLD and CAC.

Clinical outcomes of on-pump versus off-pump coronary-artery bypass surgery: a meta-analysis.

Background: The ongoing debate regarding off-pump coronary artery bypass grafting (CABG) and on-pump CABG has endured for over three decades. Although numerous randomized controlled trials (RCTs) and meta-analyses have been reported, new evidence has emerged. Therefore, an updated and comprehensive meta-analysis to guide clinical practice is essential.

Clinical significance of hemoglobin level and blood transfusion therapy in elderly sepsis patients: A retrospective analysis.

Introduction: The clinical significance of hemoglobin level and blood transfusion therapy in elderly sepsis patients remains controversial. The study investigated the relationship between mortality, hemoglobin levels, and blood transfusion in elderly sepsis patients.

Methods: Elderly sepsis patients were included in the Marketplace for Medical Information in Intensive Care (MIMIC-IV) database.