Unravelling the mechanism of action of Huashibaidu formula volatile metabolome for the treatment of COVID-19 and its mutants from the perspectives of network pharmacology and molecular docking.

Background: Huashibaidu (HSBD) formula, as one of the "3 medicines and 3 prescriptions," has made a great contribution to the fight against COVID-19. As an RNA virus, SARS-CoV-2 is still mutating, and people are still suffering from the disease.

Methods: In the study, gas chromatography-mass spectrometry was utilized to identify the volatile compounds in the volatile oil of the HSBD formula.

Synergistic coupling of ultrasonic cavitation with tailored deep eutectic solvent systems for intensified extraction of Scutellaria Radix flavonoids: Modelling and optimization by genetic algorithm.

Deep eutectic solvents (DESs) are increasingly recognized as viable environmentally friendly alternatives to traditional organic solvents because of their low toxicity and exceptional dissolving capabilities. In this research, 12 DESs were synthesized and systematically integrated with ultrasonic-assisted extraction (UAE) to extract flavonoids from Scutellaria Radix. Comprehensive screening revealed that the optimal DES outperformed conventional solvents (water and 70 % ethanol) in extraction efficiency.

Metabolomic profiles and differential metabolites of volatile components in Changshan-huyou pericarp during different growth and development stages.

Citrus fruits possess a distinctive aroma and flavor, with Changshan-huyou (CACH) standing out due to their considerable edible and medicinal value. However, the volatile components (VOCs) in the CACH pericarp (CP) remain underexplored. In this study, gas chromatography-mass spectrometry (GC-MS) was utilized to qualitatively analyze VOCs in 27 CP samples across different growth stages.

Efficient "pure" blue OLEDs employing tetradentate Pt complexes with a narrow spectral bandwidth.

Efficient deep-blue-emitting tetradentate platinum complexes with a narrow spectral bandwidth are presented, which demonstrate CIEx ≈ 0.15 and CIEy < 0.1.

The recent development of Organofluorine chemistry in China: asymmetric construction of stereogenic trifluoromethyl-substituted carbon centers.

The stereospecific incorporation of the trifluoromethyl group into an organic compound has attracted considerable attention and significant progress has been achieved in the past decade. Scholars from China have also contributed greatly to this field, which is the subject of the current review.

Enantioselective Friedel-Crafts alkylation of indoles with trifluoroethylidene malonates by copper-bis(oxazoline) complexes: construction of trifluoromethyl-substituted stereogenic tertiary carbon center.

An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II)-bis (oxazoline) complexes has been developed. The expected adducts with a stereogenic tertiary carbon center bearing a trifluoromethyl group were obtained in excellent yields (up to 99%) and ee values (up to 96% ee). The synthetic utility of this asymmetric catalytic reaction was demonstrated by the preparation of β-CF(3)-tryptophan and 4-CF(3)-β-carboline in high ee.

Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonates.

An efficient, highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described. The asymmetric reaction provided highly optically pure β-trifluoromethyl aldehydes which can be conveniently transformed into 4,4,4-trifluoromethyl butyric acid and trifluoromethyl substituted δ-lactones without loss in enantioselectivity.