Publications by authors named "Laura Capoccia"

Cerebral arteriovenous malformations (AVMs) are rare vascular anomalies associated with a risk of devastating intracerebral hemorrhage. They are often diagnosed following the appearance of seizures, focal neurological signs, or bleeding. In such cases endovascular embolization, which aims to occlude the AVM nidus and reduce risk of hemorrhage, has become a crucial therapeutic approach.

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Objective: To assess the prevalence and risk factors for the development of myocardial injury (MIn) in patients undergoing carotid revascularisation and to assess whether elevated troponin levels can predict the occurrence of adverse cardiac events and short term death.

Methods: This prospective, multicentre cohort study included 527 patients subjected to carotid revascularisation from June to October 2023. High sensitive cardiac troponin I and or T were assessed pre-operatively, and eight and 24 hours post-operatively.

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Background: Transcarotid artery revascularization (TCAR) has emerged as an alternative therapeutic modality to carotid endarterectomy (CEA) and transfemoral carotid artery stenting (TFCAS) for the management of patients with carotid artery stenosis. However, certain issues regarding the indications and contraindications of TCAR remain unanswered or unresolved. The aim of this international, expert-based Delphi consensus document was to attempt to provide some guidance on these topics.

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Article Synopsis
  • AI has evolved since its introduction in 1956 and is now significantly impacting healthcare, especially in patient care and information management.
  • Key AI functions like Machine Learning and Deep Learning, along with Biomimetic Intelligence, are being utilized to analyze medical data and create algorithms for better diagnosis and treatments.
  • The rising incidence of chronic limb-threatening ischemia due to diabetes and aging populations presents a challenge that AI and BI can help address by improving treatment planning and resource integration for peripheral artery disease.
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Background: Carotid near-occlusion (CNO) represents an anatomical-functional condition characterized by severe (more than 90%) internal carotid artery stenosis which can lead to a distal lumen diameter greater or less than 2 mm. CNO can be divided into a less severe subgroup (without lumen full collapse: diameter >2 mm) and a more severe subgroup (with lumen full collapse: diameter <2 mm). The decision for revascularization is still highly debated in Literature.

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  • A recent study evaluated the effectiveness of second-generation carotid stents (SGS) compared to traditional single-layer stents and carotid endarterectomy (CEA), finding that SGS can lead to better outcomes in certain cases.
  • Data from over 100,000 patients indicated that specific SGS designs, like Casper/Roadsaver and CGuard, significantly reduced the risk of death, stroke, and myocardial infarction compared to CEA, while Gore stent outcomes were generally poorer.
  • Overall, the findings suggest that certain SGS types may offer advantages over CEA, but the performance varies by stent design, highlighting the need for cautious interpretation and consideration of individual patient circumstances.
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Objective: Despite the publication of various national/international guidelines, several questions concerning the management of patients with asymptomatic (AsxCS) and symptomatic (SxCS) carotid stenosis remain unanswered. The aim of this international, multi-specialty, expert-based Delphi Consensus document was to address these issues to help clinicians make decisions when guidelines are unclear.

Methods: Fourteen controversial topics were identified.

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Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling or fatal. Such strokes could be largely prevented through optimal medical therapy and carotid revascularization. Advancements in discovery research and imaging along with evidence from recent pharmacology and interventional clinical trials and registries and the progress in acute stroke management have markedly expanded the knowledge base for clinical decisions in carotid stenosis.

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Article Synopsis
  • The review focused on gathering the latest information about anesthesia and other medical practices for a surgery called carotid endarterectomy.
  • They examined many studies from specific medical databases to find the best practices and results.
  • The findings suggested that using any anesthesia and checking brain function during surgery can help patients do better, but there wasn't enough proof on whether to reverse a medicine called heparin after surgery. They also mentioned keeping an eye on blood pressure after surgery, even though the evidence was weak.
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Purpose: Patients undergoing carotid endarterectomy (CEA) or carotid artery stenting (CAS) are at substantially increased risk of short-term and long-term cardiac complications. Still, the role of perioperative troponin in predicting cardiac events remains unclear. The objective was to systematically summarize the existing evidence on the topic and provide directions for further research.

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Background: Arterial and venous thrombosis are complications in SARS-CoV-2-infected patients. The microangiopathic thrombosis in affected patients can compromise results in urgent limb revascularizations. Aim of our study is to report on the incidence of symptoms development in patients affected by popliteal artery aneurysm (PAA) and to analyze the effect of COVID-19 infection on outcomes.

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  • Current guidelines advise against screening for asymptomatic carotid artery stenosis (AsxCS) due to the risk of unnecessary interventions, unlike the strong recommendation for abdominal aortic aneurysm screening.
  • A literature analysis reveals that patients with AsxCS are at a high risk for future cardiovascular issues, yet universal screening is not advisable.
  • Selective screening for high-risk individuals could be beneficial, focusing on risk factor management and medical therapy to prevent future cardiovascular events rather than identifying candidates for surgery.
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Background: Single-cohort studies suggest that second-generation stents (SGS; “mesh stents”) may improve carotid artery stenting (CAS) outcomes by limiting peri- and postprocedural cerebral embolism. SGS differ in the stent frame construction, mesh material, and design, as well as in mesh-to-frame position (inside/outside). Objectives: To compare clinical outcomes of SGS in relation to first-generation stents (FGSs; single-layer) in CAS.

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Background: This guideline (GL) on carotid surgery as updating of "Stroke: Italian guidelines for Prevention and Treatment" of the ISO-SPREAD Italian Stroke Organization-Group, has recently been published in the National Guideline System and shared with the Italian Society of Vascular and Endovascular Surgery (SICVE) and other Scientific Societies and Patient's Association.

Methods: GRADE-SIGN version, AGREE quality of reporting checklist. Clinical questions formulated according to the PICO model.

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True and false aneurysms (FA) of the subclavian artery are at high risk of rupture due to their localization and proximity/closeness to the articular bone structures of the upper thoracic outlet and shoulders. Surgical and endovascular treatments are good options to avoid complications such as aneurysms rupture, thrombosis and distal embolism alone or in combination. Self-expandable (SE) covered stents are the most used devices for the treatment of subclavian artery aneurysms.

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Objectives: The aim of this study was to evaluate the 1-year safety and efficacy of a dual-layered stent (DLS) for carotid artery stenting (CAS) in a multicenter registry.

Background: DLS have been proved to be safe and efficient during short-term follow-up. Recent data have raised the concern that the benefit of CAS performed with using a DLS may be hampered by a higher restenosis rate at 1 year.

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Background: Carotid artery stenting (CAS) has become a valid alternative to carotid endarterectomy in stroke prevention. However, female gender is still considered as an independent risk factor for CAS procedures, potentially limiting immediate and long-term benefits. Aim of present study was to evaluate gender differences in CAS submitted patients from an Italian high-volume center.

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Purpose: to evaluate the impact of bi- and 3-dimensional preoperative aortic morphological features and their immediate postoperative variations on the outcome of abdominal aortic aneurysms (AAA) treated by endovascular exclusion with standard devices (EVAR).

Materials And Methods: Double centre retrospective analysis of prospectively collected registry data of EVAR patients. For all patients, preoperative and 30-day computed tomographic angiography images (CTA) were reviewed.

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Objectives: This study sought to evaluate 30-day safety and efficacy of dual-layer mesh-covered carotid stent systems for carotid artery stenting (CAS) in the clinical practice.

Background: When compared with carotid endarterectomy, CAS has been associated with a higher rate of post procedural neurologic events; these could be related to plaque's debris prolapsing through stent's mesh. Consequently, the need for increased plaque coverage has resulted in the development of dual-layer mesh-covered carotid stent systems.

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Background: The aim of the present study was to evaluate early-, mid-, and long-term outcomes in an unselected population of patients treated for abdominal aortic aneurysms (AAAs) by endovascular aneurysm repair (EVAR) with different commercially available off-the-shelf devices.

Materials And Methods: A retrospective study was conducted on a prospectively compiled computerized database on patients presenting an infrarenal AAA treated between January 2008 and December 2015 in a high-volume Italian tertiary referral Center. Demographic, clinical, and specific morphological features were considered as potentially influencing the outcomes and the type of the implanted device.

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